ACKR1 (Atypical Chemokine Receptor 1): ACKR1 is a receptor involved in the bodyâs regulation of chemokine activity. Formerly referred to as DARC (Duffy Antigen Receptor for Chemokines), ACKR1 functions as a decoy receptor, binding chemokines without initiating intracellular signalling. By capturing chemokines, it helps regulate immune responses and control inflammation, thereby protecting tissues from excessive damage. Variations in ACKR1 are associated with differences in susceptibility to infections and the severity of inflammatory diseases.