AGPAT2
AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2) is a vital enzyme involved in lipid metabolism, specifically in the synthesis of phospholipids and triglycerides. It catalyses the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a crucial step in the Kennedy pathway for triacylglycerol production. AGPAT2 plays significant roles in adipocyte differentiation, lipid storage, and membrane formation. Dysregulation of AGPAT2 activity has been linked to metabolic conditions such as obesity, insulin resistance, and dyslipidaemia, while mutations in the AGPAT2 gene are associated with congenital generalised lipodystrophy type 1 (CGL1), a rare genetic disorder affecting fat distribution.
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