AGPAT2

AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2): AGPAT2 is a crucial enzyme involved in lipid metabolism, particularly in the biosynthesis of phospholipids and triglycerides. It catalyzes the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a key step in the Kennedy pathway for triacylglycerol synthesis. AGPAT2 plays a vital role in various cellular processes such as adipocyte differentiation, lipid storage, and membrane biogenesis. Dysregulation of AGPAT2 activity has been implicated in metabolic disorders such as obesity, insulin resistance, and dyslipidemia. Additionally, mutations in the AGPAT2 gene are associated with congenital generalized lipodystrophy type 1 (CGL1), a rare genetic disorder characterized by the...