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Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

DNA Fatigue Test

DNA Diet & Nutrition from GetTested is a health test that analyses your genetic variations to provide a detailed understanding of how your body processes various nutrients. Utilizing a simple saliva sample for DNA collection, this test delivers insights into your genetic makeup related to diet and nutrition. It offers a personalized analysis of macronutrients, fat metabolism, vitamin and mineral requirements, as well as genetic predispositions to various sensitivities/intolerances and eating behaviors.

DNA Diet & Nutrition from GetTested is a health test that analyses your genetic variations to provide a detailed understanding of how your body processes various nutrients. Utilizing a simple saliva sample for DNA collection, this test delivers insights into your genetic makeup related to diet and nutrition. It offers a personalized analysis of macronutrients, fat metabolism, vitamin and mineral requirements, as well as genetic predispositions to various sensitivities/intolerances and eating behaviors.

DNA Diet & Nutrition Test

GetTested’s DNA Brain Health test provides a detailed genetic analysis of 288 genes to understand factors that affect your mental health. This at-home test examines specific genes related to memory, stress management, anxiety susceptibility, and mood swings, offering a comprehensive insight into how your unique genetic makeup impacts your mental well-being.

GetTested’s DNA Brain Health test provides a detailed genetic analysis of 288 genes to understand factors that affect your mental health. This at-home test examines specific genes related to memory, stress management, anxiety susceptibility, and mood swings, offering a comprehensive insight into how your unique genetic makeup impacts your mental well-being.

DNA Brain Health Test

FGD4 (FYVE, RhoGEF, and PH Domain Containing 4): FGD4 encodes a guanine nucleotide exchange factor that specifically activates Cdc42, a member of the Rho family of GTPases. This activation plays a key role in regulating cytoskeletal organization, cell shape, and migration. Mutations in FGD4 are associated with Charcot-Marie-Tooth disease, a disorder affecting peripheral nerves, highlighting its importance in nerve development and function....

FGD4

SHC1 (SHC Adaptor Protein 1): SHC1 is an adaptor protein involved in the signal transduction pathways that regulate cell growth, differentiation, and survival. By mediating the activation of the Ras/MAPK signaling pathway, SHC1 influences cellular responses to growth factors and cytokines. Dysregulation of SHC1 has been implicated in the development of various cancers, as well as in cardiovascular diseases, highlighting its critical role in cellular signaling and disease pathogenesis....



SHC1

FGF10 (Fibroblast Growth Factor 10): FGF10 is critical in embryonic development, particularly in limb and lung development. It's involved in the proliferation and differentiation of cells in these tissues, and mutations can lead to developmental disorders like aplasia of the lung....

FGF10

SHISA4 (Shisa Family Member 4): SHISA4 is involved in the regulation of synaptic function and neuronal excitability. It modulates the activity of key receptors in the central nervous system, including AMPA and NMDA receptors, and is implicated in the regulation of neuronal signaling and plasticity. Its role in synaptic modulation makes it a gene of interest in the study of neurological disorders and synaptic dysfunctions....



SHISA4

FGF13 (Fibroblast Growth Factor 13): FGF13, a member of the fibroblast growth factor (FGF) family, operates at the crossroads of cellular growth and differentiation. This protein is a key orchestrator in the complex symphony of cellular processes, influencing cell development and differentiation. Its spotlight in the realm of neuroscience is well-established, where it contributes to the functioning of neurons. Researchers delve into the depths of FGF13's impact on neurological disorders, aiming to unlock its potential in understanding conditions that affect the brain and nervous system....

FGF13

SHLD1 (Shieldin Complex Subunit 1): SHLD1 is a component of the shieldin complex, which plays a key role in DNA repair. It is involved in the repair of double-strand breaks, particularly in non-homologous end joining, a crucial process for maintaining genomic stability and preventing mutagenesis....



SHLD1

SHMT1 (Serine Hydroxymethyltransferase 1): SHMT1 catalyzes the conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate, crucial for nucleotide synthesis and methylation reactions. Its function is vital for DNA replication and repair, impacting cell proliferation and genetic stability. SHMT1's role in folate metabolism links it to cancer risk and neurological disorders....



SHMT1

SHPRH (SNF2 Histone Linker PHD RING Helicase): SHPRH is a DNA helicase involved in the repair of DNA damage and the maintenance of genomic stability. It plays a critical role in the DNA damage response by facilitating the repair of DNA double-strand breaks, thereby preventing mutations that could lead to cancer. SHPRH has been identified as a tumor suppressor, with mutations in this gene associated with increased susceptibility to various cancers, highlighting its importance in protecting against genomic instability and tumorigenesis....



SHPRH

SHQ1 (SHQ1, H/ACA Ribonucleoprotein Assembly Factor): SHQ1 is a crucial assembly factor for H/ACA ribonucleoproteins (RNPs), which are involved in the processing and modification of RNA. This includes the maturation of rRNA, snRNA, and the stabilization of telomerase RNA component (TERC). SHQ1 plays a vital role in the biogenesis of H/ACA RNPs, essential for proper cell function and maintenance of genomic stability. Disruptions in SHQ1 function can lead to defects in RNA processing and are implicated in various cellular dysfunctions....



SHQ1

FHIT (Fragile Histidine Triad Diadenosine Triphosphatase): FHIT is a tumor suppressor gene involved in purine metabolism. Loss or alteration of this gene has been linked to a variety of cancers, indicating its role in tumor suppression....

FHIT

SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1): SORCS1 is a gene that encodes a receptor involved in protein trafficking and sorting. It plays a role in the regulation of receptor signaling and may have implications in neural development and synaptic function. ...



SORCS1

FHOD3 (Formin Homology 2 Domain Containing 3): FHOD3 is a member of the formin family of proteins, which play a crucial role in the organization and regulation of the actin cytoskeleton. This protein is particularly significant in cardiac muscle and other tissues, where it facilitates the assembly of actin filaments, thereby influencing cell shape, adhesion, and motility. FHOD3's activity is pivotal during cell division, migration, and muscle contraction, contributing to the proper functioning of cardiovascular and skeletal systems. Its regulatory mechanisms involve the dynamic remodeling of the actin cytoskeleton, essential for heart development and function. Dysregulation of FHOD3 has been...

FHOD3

SORCS2 (Sortilin-Related VPS10 Domain Containing Receptor 2): SORCS2 is involved in neuronal development and signaling. It is a member of the VPS10 domain-containing receptor family, which plays roles in neurotrophic signaling and neural plasticity. Dysregulation of SORCS2 has been linked to neurological disorders, including Alzheimer’s disease and schizophrenia....



SORCS2

FIBIN (Fibin): FIBIN is a gene that encodes a protein involved in embryonic development, particularly in the development of the heart and blood vessels. It plays a role in signaling pathways that regulate cell differentiation and tissue morphogenesis. Mutations in FIBIN are implicated in developmental disorders....

FIBIN

SIDT1 (SID1 Transmembrane Family, Member 1): SIDT1 is involved in the cellular uptake of double-stranded RNA, playing a role in RNA interference and antiviral responses. It is significant in understanding cellular mechanisms for fighting viral infections and in the study of RNA-based therapeutic strategies....



SIDT1

SORCS3 (Sortilin-Related VPS10 Domain Containing Receptor 3): SORCS3 is a member of the VPS10 domain-containing receptor family and plays a role in protein trafficking and sorting within cells. It is particularly important in the nervous system, where it regulates the trafficking of proteins involved in synaptic function. Dysregulation of SORCS3 has been linked to neurological disorders, including Alzheimer's disease and schizophrenia....



SORCS3

FYB2 (FYN Binding Protein 2): FYB2, also known as ADAP2, is involved in signal transduction pathways within immune cells. It acts as an adaptor protein, mediating interactions between various signaling molecules, and plays a role in the regulation of immune cell activation and response. Its function is important for understanding the mechanisms of immune regulation and potential immune-related disorders....

FYB2

SOS2 (Son of Sevenless Homolog 2): SOS2 is involved in cell signaling and the activation of the Ras/MAPK pathway. It serves as a crucial mediator in cellular responses to growth factors, cytokines, and extracellular signals, contributing to various physiological processes and cellular outcomes....



SOS2

FKBP4, also known as FK506-binding protein 4 or FKBP52, is a member of the FK506-binding protein (FKBP) family, which are peptidyl-prolyl cis-trans isomerases (PPIases) that function as molecular chaperones. FKBP4 is primarily found in the cytoplasm and nucleus of cells and is involved in regulating protein folding, trafficking, and signal transduction. One of the primary functions of FKBP4 is its role as a co-chaperone for steroid hormone receptors, including the glucocorticoid receptor (GR) and androgen receptor (AR). FKBP4 interacts with these receptors in the cytoplasm, facilitating their proper folding and assembly into functional complexes with heat shock proteins (HSPs). Upon ligand...

FKBP4

FZD1 (Frizzled Class Receptor 1): FZD1 is a member of the frizzled receptor family, pivotal components of the Wnt signaling pathway. This pathway plays a central role in developmental processes, tissue regeneration, and cancer progression. FZD1, as a Wnt receptor, serves as a key player in modulating cellular responses to Wnt ligands, thereby influencing critical biological events and holding potential implications in disease mechanisms....

FZD1

SIDT2 (SID1 Transmembrane Family Member 2): SIDT2 is involved in the cellular uptake of RNA molecules, playing a role in RNA interference (RNAi) mechanisms. It's important in the study of gene regulation and has potential implications in the development of RNA-based therapeutics. The function of SIDT2 in RNA transport is crucial for understanding how cells regulate gene expression and respond to external RNA molecules....



SIDT2

SOX2, short for SRY (Sex Determining Region Y)-Box 2, is a critical transcription factor that plays a pivotal role in embryonic development, stem cell pluripotency, and tissue homeostasis. Positioned predominantly within the nucleus of cells, SOX2 is involved in the regulation of gene expression by binding to specific DNA sequences and modulating the activity of target genes. One of the primary functions of SOX2 is its involvement in the maintenance of stem cell pluripotency and self-renewal. Alongside other transcription factors, such as OCT4 and NANOG, SOX2 forms a core regulatory network that sustains the undifferentiated state of embryonic stem cells and...

SOX2

FZD10 (Frizzled Class Receptor 10): FZD10 is a receptor for Wnt signaling proteins, playing an essential role in embryonic development, cell proliferation, and differentiation. This gene is particularly involved in the Wnt/β-catenin signaling pathway and has been implicated in cancer development, especially in the context of abnormal Wnt signaling....

FZD10

SOX4 (SRY-Box Transcription Factor 4): SOX4 is a transcription factor that plays a pivotal role in the regulation of embryonic development and cell fate determination. It is critical for the development of the heart, pancreas, and lymphocytes, as well as in the process of tumorigenesis. Overexpression of SOX4 has been implicated in the progression of several cancers, serving as a key regulator of cell proliferation, apoptosis, and metastasis, thus highlighting its dual role in development and cancer....



SOX4

FZD4 (Frizzled Class Receptor 4): FZD4 is a gene that encodes a receptor for Wnt signaling molecules. The Wnt signaling pathway is essential for embryonic development, tissue homeostasis, and stem cell regulation. FZD4's role in this pathway makes it a key player in processes like cell fate determination and tissue regeneration....

FZD4

FLG (Filaggrin): FLG encodes a protein crucial for skin barrier function. Mutations in FLG are strongly associated with skin conditions like atopic dermatitis (eczema) and can increase the risk of other allergic diseases....

SIGLEC1 (Sialic Acid Binding Ig-Like Lectin 1): Also known as sialoadhesin or CD169, SIGLEC1 is a member of the I-type lectins, recognizing sialic acid residues on cell surfaces. It is expressed primarily on macrophages and plays roles in cell-cell interactions, mediating binding to sialylated pathogens, and modulating immune responses. SIGLEC1 has been implicated in the regulation of immune surveillance and in the pathogenesis of infectious diseases and certain cancers....



SIGLEC

SOX5 (SRY-Related HMG-Box Gene 5): SOX5 is a member of the SOX (SRY-related HMG-box) family of transcription factors, known for playing a pivotal role in the regulation of embryonic development and the determination of cell fate. It is involved in a wide range of biological processes, including the regulation of chondrogenesis, the development of the nervous system, and the differentiation of various cell types. SOX5 functions by binding to DNA and influencing the transcription of genes crucial for cell growth, development, and differentiation. Mutations or dysregulation of SOX5 have been implicated in diverse pathological conditions, such as developmental disorders and...



SOX5

FLNB (Filamin B): FLNB encodes a protein that is crucial for the cross-linking of actin filaments in the cytoskeleton. Mutations in FLNB cause a range of skeletal disorders known as filaminopathies, which include conditions like spondylocarpotarsal synostosis syndrome and Larsen syndrome. These disorders are characterized by skeletal malformations and joint dislocations....

FLNB

FZD8 (Frizzled Class Receptor 8): FZD8 encodes a receptor for Wnt signaling proteins, playing a pivotal role in embryonic development and cell signaling pathways. This gene is essential in various processes including cell differentiation, proliferation, and polarity. Abnormalities in FZD8 signaling are associated with developmental defects and various cancers....

FZD8

SIK2 (Salt-Inducible Kinase 2): SIK2 is part of the AMPK family of kinases and is involved in energy homeostasis. It plays a role in the regulation of lipid and glucose metabolism and has been implicated in obesity, diabetes, and cancer metabolism....



SIK2

SOX6 (SRY-Box Transcription Factor 6): SOX6 plays a critical role in the development and differentiation of various tissues, including cartilage, muscle, and the central nervous system. It is essential for chondrocyte differentiation and skeletal development, and its expression levels are also crucial in the regulation of neuronal development and differentiation. Dysregulation of SOX6 has been implicated in various disorders, including skeletal malformations and potential impacts on cognitive function, reflecting its diverse roles in developmental processes....



SOX6

SIM1 (Single-Minded Homolog 1): SIM1 is a transcription factor that plays a crucial role in the development of specific brain regions, including the hypothalamus. It is involved in the regulation of appetite and energy homeostasis. Mutations in SIM1 have been associated with obesity and other metabolic disorders....



SIM1

G2E3 (G2/M-Phase Specific E3 Ubiquitin Protein Ligase): G2E3 is an E3 ubiquitin ligase that plays a role in cell cycle regulation, particularly in the G2/M phase transition. It is involved in the ubiquitination and degradation of cell cycle regulators, and its dysregulation can lead to cell cycle abnormalities and contribute to tumorigenesis....

G2E3

SIPA1L3 (Signal-Induced Proliferation-Associated 1 Like 3): SIPA1L3 is a gene that plays a role in signal transduction and cellular proliferation. It is particularly important in the nervous system, where it contributes to synaptic regulation and neuronal signaling. Abnormalities in SIPA1L3 have potential implications in neurological disorders, possibly affecting cognitive functions and neurodevelopment....



SIPA1L3

SIRT1 (Sirtuin 1): SIRT1 is a member of the sirtuin family of proteins, known for their roles in regulating cellular processes through deacetylation of proteins. SIRT1, in particular, has garnered attention for its involvement in longevity and aging. It plays a central role in gene regulation, DNA repair, and cellular stress responses, making it a pivotal player in the quest to understand aging and age-related diseases....



SIRT1

FLT3 (Fms-Like Tyrosine Kinase 3): FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells into mature blood cells. Mutations in FLT3, particularly activating mutations, are commonly found in acute myeloid leukemia (AML) and are associated with poor prognosis. Targeting FLT3 through inhibitors is a therapeutic strategy in treating AML and other hematological malignancies with FLT3 mutations....

FLT3

SOX9 (SRY-Box Transcription Factor 9): SOX9 is a transcription factor that plays a crucial role in development, particularly in the formation of various tissues, including cartilage, bone, and the male gonads. Mutations in SOX9 can lead to skeletal and reproductive developmental abnormalities....

SOX9

SP9 (Sp9 Transcription Factor): SP9 is a transcription factor involved in brain development. It's crucial for the regulation of genes in neural progenitor cells and has been studied in the context of neurodevelopmental processes and disorders....

SIVA1 (SIVA1 Apoptosis-Inducing Factor): SIVA1 steps onto the stage as a conductor of cellular destiny, playing a role in the intricate symphony of programmed cell death, known as apoptosis. Its influence extends to the regulation of cell survival and death pathways, holding the balance between life and death within our cells. Researchers delve into the complexities of SIVA1's role in apoptosis, seeking to understand its contributions to cellular fate and disease....



SIVA1

SPATA2 (Spermatogenesis Associated 2): SPATA2 is involved in the regulation of cell death and inflammation through its role in the TNF receptor signaling pathway. It facilitates the recruitment of key enzymes to signaling complexes, crucial for the activation of cell death and inflammatory responses. Research on SPATA2 is focused on understanding its role in spermatogenesis, cell death, and inflammation, with implications for diseases where these processes are dysregulated....



SPATA2

SLC10A2 (Solute Carrier Family 10 Member 2): SLC10A2 encodes a solute carrier protein that plays a pivotal role in the transport of bile acids in the intestines. Bile acids are essential for the digestion and absorption of dietary fats. SLC10A2's function is critical in maintaining bile acid homeostasis, ensuring efficient fat absorption, and regulating cholesterol metabolism. Disruptions in SLC10A2 can lead to bile acid-related disorders and affect overall lipid metabolism....



SLC10A2

FMO2 (Flavin Containing Monooxygenase 2): FMO2 is an enzyme involved in the metabolism of xenobiotics, drugs, and other foreign compounds, using flavin adenine dinucleotide (FAD) as a cofactor. It plays a role in detoxifying nitrogen-containing compounds and is expressed mainly in the lungs. Genetic variants of FMO2 can affect its enzymatic activity and influence individual responses to certain drugs and environmental toxins....

FMO2

SPATA2L (Spermatogenesis-associated protein 2-like): SPATA2L is a protein that shares sequence similarity with SPATA2, a known regulator of cell death and inflammation pathways. While the specific function of SPATA2L is still being elucidated, studies suggest its potential involvement in cellular processes such as apoptosis, autophagy, and immune response regulation. SPATA2L may play a role in modulating signaling pathways involved in cell survival and death decisions, similar to its homolog SPATA2. These pathways are critical for maintaining tissue homeostasis and responding to cellular stressors, such as DNA damage or infection. Dysregulation of SPATA2L expression or function could potentially impact these processes, leading...

SPATA2L

SLC12A1 (Solute Carrier Family 12 Member 1): SLC12A1, a member of the solute carrier (SLC) family of transporters, assumes the role of a transporter protein responsible for ion transport, specifically the reabsorption of sodium and chloride ions in the kidney. Its function is pivotal in maintaining electrolyte balance and blood pressure regulation. In the intricate filtration processes of the renal system, SLC12A1 plays a starring role, ensuring the precise reabsorption of ions to maintain bodily homeostasis....



SLC12A1

SLC16A1 (Solute Carrier Family 16 Member 1): SLC16A1, also known as MCT1, is a transporter protein that facilitates the rapid transport of lactate and other monocarboxylates across cell membranes. It plays a key role in lactate metabolism, important in various physiological and pathological processes, including exercise physiology and cancer metabolism....



SLC16A1

SPATA32 (Spermatogenesis Associated 32): SPATA32 is primarily expressed in the testis and is believed to play a role in spermatogenesis. Its exact function in male reproductive health and fertility is not fully understood, but it is considered significant in the study of reproductive biology and potentially in fertility-related research and treatments....



SPATA32

FMO4 (Flavin Containing Monooxygenase 4): FMO4 is part of the flavin-containing monooxygenase family, enzymes that play a crucial role in the detoxification of xenobiotics, drugs, and endogenous compounds by catalyzing the oxidation of soft nucleophiles. FMO4 is expressed primarily in the liver and has a substrate specificity that can influence the metabolism and elimination of various substances, potentially affecting drug responses and toxicity. Research into FMO4 focuses on its role in metabolic pathways and its implications for pharmacology and toxicology....

FMO4

SPATA5 (Spermatogenesis-Associated 5): SPATA5 is a gene associated with spermatogenesis, the process of sperm cell development. It is crucial for male fertility as it plays a role in sperm formation. Mutations in SPATA5 can lead to fertility issues and are linked to male infertility....

SPATA5

SLC16A9 (Solute Carrier Family 16 Member 9): SLC16A9 is a member of the solute carrier family and is involved in transporting small molecules across cell membranes. Its specific substrate and functions are still being elucidated....



SLC16A9

FN3KRP (Fructosamine 3 Kinase-Related Protein): FN3KRP is associated with fructosamine metabolism and may have a role in the regulation of glucose levels. It is related to the enzyme fructosamine 3 kinase and may have implications in glycation processes, which are involved in the formation of advanced glycation end-products (AGEs) and their impact on diabetes and aging-related diseases....

FN3KRP

SPATA6 (Spermatogenesis Associated 6): SPATA6 is important in spermatogenesis, the process of sperm cell development. It is involved in the formation and function of spermatozoa. Mutations in SPATA6 can lead to male infertility, making it a significant gene in the study of reproductive health....

SPATA6

SLC17A1 (Solute Carrier Family 17 Member 1): SLC17A1 encodes a vesicular glutamate transporter, which is responsible for packaging and releasing glutamate, a neurotransmitter, into synaptic vesicles. It plays a crucial role in neuronal communication and synaptic transmission....



SLC17A1

SLC1A1

SLC20A2 (Solute Carrier Family 20 Member 2): SLC20A2 is a phosphate transporter involved in phosphate homeostasis. Mutations in this gene can lead to primary familial brain calcification, a condition characterized by abnormal calcium-phosphate deposits in the brain....

SLC20A2

SPATA7 (Spermatogenesis Associated 7): SPATA7 is important in eye and reproductive system development. Mutations in SPATA7 are linked to Leber congenital amaurosis and retinitis pigmentosa, both of which are retinal degenerative diseases leading to vision loss....



SPATA7

SLC22A23 (Solute Carrier Family 22 Member 23): SLC22A23 belongs to a family of transporters that facilitate the movement of organic ions and small molecules across cell membranes. While the specific substrates and physiological roles of SLC22A23 are not well-established, it is thought to play a role in the transport of organic compounds in various tissues, potentially impacting drug disposition and metabolic processes....



SLC22A23

SPATS2L (Spermatogenesis Associated Serine Rich 2-Like): SPATS2L is a gene associated with spermatogenesis, the process of sperm cell development. It may play a role in male fertility, but further research is needed to fully understand its function and implications....



SPATS2L

SLC23A1 (Solute Carrier Family 23 Member 1): SLC23A1 is important in the transport of ascorbic acid (vitamin C) into cells. It plays a key role in maintaining optimal levels of vitamin C, which is crucial for immune function, collagen synthesis, and antioxidant protection. Genetic variations in SLC23A1 can influence an individual's vitamin C requirements and susceptibility to conditions related to vitamin C deficiency....



SLC23A1

G6PC2 (Glucose-6-Phosphatase Catalytic Subunit 2): G6PC2 is involved in glucose metabolism and catalyzes the hydrolysis of glucose-6-phosphate to glucose. It plays a pivotal role in glucose homeostasis by regulating blood glucose levels, making it a significant contributor to overall metabolic health....

G6PC2

SLC24A2 (Solute Carrier Family 24 Member 2): SLC24A2 encodes a potassium-dependent sodium/calcium exchanger, which is important for calcium homeostasis in cells. It's particularly expressed in the retina and the brain, suggesting roles in neural function and vision. Mutations or dysfunction in SLC24A2 can have implications for neurological and visual disorders....



SLC24A2

GABPB1: GABPB1, or GA Binding Protein Transcription Factor Beta Subunit 1, is a gene involved in cellular transcription regulation. It encodes a subunit of a transcription factor that regulates genes implicated in cell growth and metabolism. Alterations in GABPB1 have been associated with different types of cancer, highlighting its role in cell proliferation and survival....

GABPB1

SLC24A4 (Solute Carrier Family 24 Member 4): SLC24A4 is involved in calcium and sodium ion transport, particularly in the formation of dental enamel and regulation of melanogenesis. Mutations in SLC24A4 are associated with amelogenesis imperfecta, a condition affecting tooth enamel, and may have implications in pigmentation disorders....



SLC24A4

SLC25A34 (Solute Carrier Family 25 Member 34): SLC25A34 belongs to the solute carrier family, which is involved in the transport of various molecules across cellular membranes. The specific function of SLC25A34 is not well understood, but members of this family are crucial for metabolic processes and cellular homeostasis. Studying this gene could provide insights into metabolic disorders and cellular transport mechanisms....



SLC25A34

GAD2 (Glutamate Decarboxylase 2): GAD2 is crucial for the synthesis of gamma-aminobutyric acid (GABA), an important neurotransmitter in the brain. It plays a role in the regulation of neuronal excitability and has been implicated in disorders such as epilepsy and anxiety disorders....

GAD2

SLC26A5 (Solute Carrier Family 26 Member 5, also known as Prestin): SLC26A5, or Prestin, is a motor protein in the outer hair cells of the cochlea, essential for sound amplification and hearing. It acts as a voltage-sensitive motor protein, contributing to the exquisite sensitivity and frequency selectivity of the cochlea. Mutations or dysregulation of SLC26A5 can affect hearing function, making it a significant focus for understanding the molecular basis of hearing and for developing treatments for hearing loss....



SLC26A5

SLC26A8 (Solute Carrier Family 26 Member 8): SLC26A8 is a transporter protein, particularly important in testis for sperm motility and fertility. It is involved in anion transport and is essential for proper sperm function and male fertility....



SLC26A8

SPG7 (Spastic Paraplegia 7, Paraplegin): SPG7 is a mitochondrial protein that plays a role in the maintenance and function of mitochondria, particularly in the ATPase assembly. Mutations in SPG7 are a common cause of hereditary spastic paraplegia, a neurodegenerative disorder characterized by progressive stiffness and weakness of the lower limbs, reflecting its importance in neural and mitochondrial function....

SPG7

SLC2A9 (Solute Carrier Family 2 Member 9): SLC2A9 encodes a transporter protein involved in urate transport in the kidneys. It plays a crucial role in regulating uric acid levels in the blood and is associated with gout susceptibility....



SLC2A9

SLC30A8 (Solute Carrier Family 30 Member 8): SLC30A8 is involved in zinc transport and insulin secretion from pancreatic beta cells. It plays a role in glucose homeostasis and is a potential target for the treatment of type 2 diabetes....



SLC30A8

SLC30A9 (Solute Carrier Family 30 Member 9): SLC30A9 is a zinc transporter, involved in the regulation of zinc homeostasis in cells. Zinc is essential for numerous biological processes, and dysregulation of zinc transport can have implications for cell growth, immune function, and neuronal development....



SLC30A9

SPINK5 (Serine Peptidase Inhibitor, Kazal Type 5): SPINK5 is a crucial gene for skin integrity and immune response, encoding a serine protease inhibitor that regulates the activity of various enzymes in the skin. Mutations in SPINK5 are associated with Netherton syndrome, a severe skin disorder characterized by inflammation, scaling, and increased allergy susceptibility. Its study is vital for understanding skin diseases and developing potential treatments for disorders related to skin barrier dysfunction....



SPINK5

SLC35F1 (Solute Carrier Family 35 Member F1): SLC35F1 is a member of the solute carrier family, specifically involved in the transport of nucleotide sugars across cellular membranes. This protein plays a crucial role in the intracellular trafficking and availability of nucleotide sugars, which are essential substrates for glycosylation processes. Glycosylation is a critical post-translational modification that affects protein folding, stability, and interactions, thereby influencing various physiological and pathological processes, including cell signaling, immune response, and cancer progression. The precise function of SLC35F1 in glycosylation underscores its importance in maintaining cellular homeostasis and the proper function of glycoproteins. Dysregulation or mutations...



SLC35F1

SLC35F2 (Solute Carrier Family 35 Member F2): SLC35F2 encodes a member of the solute carrier family involved in the transport of nucleotide sugars across the Golgi membrane, critical for glycosylation processes. Glycosylation is essential for the proper function of many proteins and lipids, impacting cell-cell communication, immunity, and pathogen recognition. The specific substrates and biological roles of SLC35F2 are subjects of ongoing research, with implications for understanding diseases related to glycosylation disorders....



SLC35F2

GADL1 (Glutamate Decarboxylase Like 1): GADL1 is similar to glutamate decarboxylases that synthesize the neurotransmitter GABA, but its specific function is less clear. It may play a role in amino acid metabolism and neurotransmitter synthesis, and is of interest in the study of neurological function and disorders....

GADL1

SLC35F3 (Solute Carrier Family 35 Member F3): SLC35F3 is a member of the solute carrier (SLC) family of transporters and is involved in the transport of various molecules across cell membranes. Its specific substrate and cellular functions are areas of ongoing research....



SLC35F3

SLC38A11 (Solute Carrier Family 38 Member 11): SLC38A11 is involved in amino acid transport and nutrient sensing. It plays a role in the regulation of mTORC1 signaling, which is important for cell growth and metabolism....



SLC38A11

GAL (Galactose Alpha-1,3-Galactosyltransferase): GAL is an enzyme involved in the synthesis of the alpha-gal epitope, a carbohydrate antigen. It plays a role in immune response and xenotransplantation, as alpha-gal epitopes can cause immune rejection. The absence of this enzyme in humans leads to the production of anti-Gal antibodies....

SLC39A8 (Solute Carrier Family 39 Member 8): SLC39A8 is a transporter protein involved in the cellular uptake of divalent cations, particularly zinc and manganese. It plays a crucial role in metal ion homeostasis and is important for various biological processes, including immune function and neural development. Mutations in SLC39A8 have been associated with multiple health issues, including congenital disorders of glycosylation....



SLC39A8

SLC44A1 (Solute Carrier Family 44 Member 1): SLC44A1, also known as choline transporter-like protein 1, plays a key role in the transport of choline, a critical component in the synthesis of the neurotransmitter acetylcholine and phospholipids in cell membranes. It is involved in various physiological processes, including neurotransmission and cell membrane integrity. Dysregulation of choline transport can impact neurological functions and has been studied in the context of diseases such as Alzheimer's and other neurodegenerative conditions....



SLC44A1

SPINK6 (Serine Peptidase Inhibitor, Kazal Type 6): SPINK6 is involved in skin barrier function and has been implicated in skin diseases. It acts as an inhibitor of serine proteases, which are important for various physiological processes including inflammation and immune response....

SPINK6

SLC44A2 (Solute Carrier Family 44 Member 2): SLC44A2 is involved in choline transport and is implicated in the modulation of immune responses and inflammation. It has been identified as a risk factor for venous thromboembolism and has a role in neutrophil migration and activation. The study of SLC44A2 is important for understanding its contributions to thrombotic disorders and immune system regulation, offering potential targets for therapeutic interventions in inflammatory and thrombotic diseases....



SLC44A2

GALNT13 (Polypeptide N-Acetylgalactosaminyltransferase 13): GALNT13 is a member of the GalNAc-transferase family, which catalyzes the initial step of O-linked glycosylation by transferring N-acetylgalactosamine (GalNAc) to serine and threonine residues of target proteins. GALNT13 specifically modifies protein substrates in the Golgi apparatus, influencing various cellular processes such as protein trafficking, secretion, and cell surface interactions. This enzyme is implicated in the post-translational modification of proteins involved in cell signaling, adhesion, and immune responses, thereby playing a critical role in cellular communication and homeostasis. Dysregulation of GALNT13 has been associated with several diseases, including cancer and metabolic disorders, underscoring its importance in...

GALNT13

FOLH1 (Folate Hydrolase 1), also known as Prostate-Specific Membrane Antigen (PSMA), is pivotal in folate metabolism, facilitating the conversion of folate to its bioactive forms. This enzyme's action is crucial for DNA synthesis and repair, impacting cell division and growth. FOLH1's expression, particularly in prostate cancer cells, makes it a target for cancer diagnostics and therapeutics. Understanding its function offers potential pathways for treating cancer and addressing folate-related metabolic disorders....

FOLH1

SLC44A5 (Solute Carrier Family 44 Member 5): SLC44A5 is a member of the solute carrier family, proteins that facilitate the transport of various substances across cellular membranes. While the specific substrates and physiological roles of SLC44A5 are not fully elucidated, it may be involved in cellular transport processes critical for maintaining homeostasis and cellular function....



SLC44A5

SPINT2 (Serine Peptidase Inhibitor, Kunitz Type 2): SPINT2, also known as HAI-2 (Hepatocyte Growth Factor Activator Inhibitor-2), is a serine protease inhibitor that plays a crucial role in regulating proteolytic pathways, including those involved in cell growth, migration, and invasion. SPINT2 is particularly important in inhibiting the activity of matriptase, a protease involved in epithelial barrier function and cellular signaling. Loss of SPINT2 function has been associated with increased risk of tumor progression and metastasis, highlighting its role in cancer suppression....




SPINT2

FOXA2 (Forkhead Box A2): FOXA2 is a transcription factor that plays a pivotal role in the development of various tissues, including the liver, pancreas, and lung. This transcription factor is involved in the regulation of genes related to metabolism, development, and differentiation. In the pancreas, FOXA2 is crucial for the development and function of insulin-producing beta cells. It plays a key role in maintaining glucose homeostasis by regulating the expression of genes involved in insulin secretion and glucose metabolism....

FOXA2

SPP1 (Secreted Phosphoprotein 1): SPP1 encodes osteopontin, a protein involved in bone remodeling, immune responses, and tissue repair. It plays a role in inflammatory processes and is associated with various diseases, including autoimmune disorders and cancer....

SPP1

SLC45A1 (Solute Carrier Family 45 Member 1): SLC45A1 is a transporter protein involved in the transport of sugars and other molecules across cellular membranes. It plays a role in metabolic processes, and its dysfunction can impact cellular energy balance and metabolism....



SLC45A1

SLC45A2 (Solute Carrier Family 45 Member 2): SLC45A2, also known as MATP (Membrane-Associated Transporter Protein), is involved in melanin synthesis as a transporter of tyrosine, a precursor in the melanin biosynthesis pathway. Variants in SLC45A2 are associated with pigmentation diversity in humans, affecting skin, hair, and eye color. Mutations in this gene can lead to oculocutaneous albinism type 4, characterized by reduced pigmentation and visual impairments. SLC45A2's role in pigmentation not only contributes to phenotypic diversity but also has implications for UV radiation protection and vitamin D synthesis....



SLC45A2

FOXJ2 (Forkhead Box J2): FOXJ2 is a transcription factor belonging to the forkhead box family, known for their roles in regulating gene expression related to growth, proliferation, and differentiation. FOXJ2 is implicated in various biological processes, and dysregulation can impact developmental pathways and may be associated with disease states....

FOXJ2

FOXK1 (Forkhead Box K1): FOXK1 is a transcription factor involved in regulating gene expression related to cell growth, proliferation, and differentiation. It plays a role in muscle development and has been implicated in metabolic regulation....

FOXK1

FOXO3 (Forkhead Box O3): FOXO3, a transcription factor, steps into the spotlight by masterfully choreographing a performance that encompasses the regulation of genes pivotal in cell cycle arrest, DNA repair, and apoptosis. In the quest for longevity and age-related diseases, FOXO3 emerges as a prominent character, orchestrating pathways that influence the aging process. The world of aging research finds FOXO3 as a central figure, with scientists aiming to decipher its role in the intricate dance of life and aging....

FOXO3

SRBD1 (S1 RNA Binding Domain 1): SRBD1 is a gene encoding an RNA-binding protein. RNA-binding proteins play essential roles in post-transcriptional regulation, including mRNA splicing and stability. Further research is needed to fully understand the specific functions of SRBD1....



SRBD1

SRD5A2, or 5-alpha-reductase 2, is an enzyme that catalyzes the conversion of testosterone into dihydrotestosterone (DHT), a more potent androgen. It is primarily expressed in androgen-sensitive tissues, including the prostate gland, hair follicles, and external genitalia. One of the primary functions of SRD5A2 is its role in androgen metabolism and the regulation of androgen signaling. Testosterone, synthesized primarily in the testes, adrenal glands, and ovaries, serves as the precursor for DHT. SRD5A2 converts testosterone into DHT by reducing the 4,5 double bond of the A ring, which increases the affinity of the androgen receptor (AR) for DHT. DHT binding to AR...



ANKK1

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