CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B): CDKN2B is a gene that plays a crucial role in regulating the cell cycle by inhibiting cyclin-dependent kinases. It is essential for controlling the G1 phase of the cell cycle and preventing uncontrolled cell proliferation. Loss of CDKN2B function is commonly observed in various cancers, underscoring its role as a tumour suppressor and its potential as a target for cancer therapies.