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The DNA Methylation Test from GetTested provides a comprehensive analysis of your body’s methylation capabilities by exploring key genes such as MTHFR, COMT, BHMT, and several others. By analyzing these genes, the test offers insights into how your body manages crucial biological processes like gene expression, DNA repair, and detoxification. Methylation plays a vital role in many of the body’s functions and can influence everything from energy production to mental well-being. This test is ideal for those seeking a deeper understanding of their health at a molecular level and wishing to tailor their diet, lifestyle, and potential supplements based on personal genetic predispositions.

The DNA Methylation Test from GetTested provides a comprehensive analysis of your body’s methylation capabilities by exploring key genes such as MTHFR, COMT, BHMT, and several others. By analyzing these genes, the test offers insights into how your body manages crucial biological processes like gene expression, DNA repair, and detoxification. Methylation plays a vital role in many of the body’s functions and can influence everything from energy production to mental well-being. This test is ideal for those seeking a deeper understanding of their health at a molecular level and wishing to tailor their diet, lifestyle, and potential supplements based on personal genetic predispositions.

DNA Methylation Test

Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

DNA Fatigue Test

GetTested’s DNA Brain Health test provides a detailed genetic analysis of 288 genes to understand factors that affect your mental health. This at-home test examines specific genes related to memory, stress management, anxiety susceptibility, and mood swings, offering a comprehensive insight into how your unique genetic makeup impacts your mental well-being.

GetTested’s DNA Brain Health test provides a detailed genetic analysis of 288 genes to understand factors that affect your mental health. This at-home test examines specific genes related to memory, stress management, anxiety susceptibility, and mood swings, offering a comprehensive insight into how your unique genetic makeup impacts your mental well-being.

DNA Brain Health Test

OLFM4 (Olfactomedin 4): OLFM4 encodes a secreted protein that is expressed in various tissues, including the gastrointestinal tract. Its functions are not fully understood, but it is associated with the regulation of stem cell proliferation and differentiation in the gut, suggesting a role in tissue regeneration and maintenance....



OLFM4

NUP93 (Nucleoporin 93): NUP93 is a component of the nuclear pore complex, which regulates the transport of molecules in and out of the cell nucleus. It is essential for maintaining the integrity of the nuclear envelope and controlling gene expression. Mutations in NUP93 have been associated with developmental disorders and cancer....



NUP93

OLIG1 (Oligodendrocyte Transcription Factor 1): OLIG1 is a key transcription factor in the development and maturation of oligodendrocytes, the cells responsible for forming myelin in the central nervous system. It plays a crucial role in myelination, which is essential for the proper functioning of the nervous system. Dysfunctions or mutations in OLIG1 can impact myelin formation and are relevant in understanding demyelinating diseases like multiple sclerosis....



OLIG1

MLXIPL (MLX-Interacting Protein-Like): MLXIPL encodes a protein involved in glucose metabolism and regulation of gene expression. It plays a role in glucose homeostasis and lipid metabolism, and mutations in MLXIPL have been associated with disorders related to carbohydrate metabolism....

MLXIPL

APCS (Amyloid P Component, Serum): APCS is a critical component of the innate immune system, playing a role in the response to infection and injury. It binds to pathogens and damaged cells, facilitating their removal. APCS is also involved in the formation of amyloid plaques, linking it to conditions like Alzheimer's disease. Its function in modulating immune responses and inflammation makes it a target for therapeutic research....

APCS

OOSP1 (Oocyte Secreted Protein 1): OOSP1 is predominantly expressed in oocytes and is involved in early embryonic development. It may play a role in the maturation of oocytes and in the regulation of processes during fertilization and early embryogenesis. Its function is crucial for reproductive health and successful embryonic development....



OOSP1

MLKL (Mixed Lineage Kinase Domain-Like): MLKL is a key player in necroptosis, a form of programmed cell death. It's involved in inflammatory responses and has been implicated in a variety of diseases, including neurodegenerative disorders, ischemic injury, and viral infections....

MLKL

MKNK2 (MAP Kinase Interacting Serine/Threonine Kinase 2): MKNK2 encodes a kinase that interacts with MAP kinases and plays a role in the regulation of protein synthesis. It is involved in various cellular processes, including stress responses and inflammation. Dysregulation of MKNK2 has been linked to cancer and other diseases involving aberrant signaling pathways....



MKNK2

OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like): OPCML is a glycosylphosphatidylinositol-anchored protein involved in cell adhesion and signaling. It has been identified as a tumor suppressor, with its expression frequently downregulated in various cancers, suggesting a protective role against tumor development and progression....



OPCML

MITF (Melanocyte Inducing Transcription Factor): MITF is crucial for the development and function of melanocytes, cells responsible for pigment production. Mutations in MITF can lead to pigmentary disorders and increase the risk of melanoma, a type of skin cancer. MITF also plays a role in the development of certain types of retinal cells and has been implicated in Waardenburg syndrome....



MITF

OPTC (Opticin): OPTC is a glycoprotein found in the eye, particularly in the vitreous humor. It is involved in maintaining the structure of the vitreous body and may play a role in ocular development and diseases....



OPTC

MICB (MHC Class I Polypeptide-Related Sequence B): MICB is a stress-induced ligand for the NKG2D receptor, which is expressed on the surface of natural killer (NK) cells, CD8+ T-cells, and certain γδ T-cells. The interaction between MICB and NKG2D plays a crucial role in the immune surveillance against malignant and infected cells. Upregulation of MICB on stressed, transformed, or infected cells can trigger an immune response leading to cell lysis. Therefore, MICB is important for immune defense against cancer and viral infections....



MICB

MOXD1 (Monooxygenase DBH-Like 1): MOXD1 is a gene involved in oxidative reactions within cells. Its precise functions and implications in human health are still being studied, but it is thought to play a role in the metabolism of certain compounds....



MOXD1

MPC1 (Mitochondrial Pyruvate Carrier 1): MPC1 is a gene associated with mitochondrial function and energy metabolism. It is involved in the transport of pyruvate into mitochondria for energy production. Dysregulation of MPC1 can impact mitochondrial metabolism....

MPC1

MPHOSPH6 (M-Phase Phosphoprotein 6): MPHOSPH6 is involved in the regulation of the cell cycle, particularly during mitosis. It is essential for proper cell division and has been studied in the context of cancer, where alterations in cell cycle regulation are a common feature....



MPHOSPH6

TSPAN3 (Tetraspanin 3): TSPAN3 encodes a member of the tetraspanin protein family, which plays a role in cell adhesion, signaling, and membrane organization. Tetraspanins are involved in various cellular processes, including immune cell activation and cancer metastasis.

TSPAN3

MPO (Myeloperoxidase): MPO is an enzyme most abundantly expressed in neutrophils and is part of the host defense system. It produces hypochlorous acid and other reactive substances from hydrogen peroxide to kill bacteria and other pathogens. While essential for microbial defense, MPO activity can also contribute to tissue damage during inflammatory responses and has been implicated in various diseases, including cardiovascular diseases, due to its role in oxidative stress....



OPTN (Optineurin): OPTN is involved in various cellular processes, including membrane trafficking, autophagy, and NF-kappaB signaling. Mutations in OPTN are linked to glaucoma and amyotrophic lateral sclerosis (ALS). Its role in autophagy and neuroinflammation makes it a significant protein in studying neurodegenerative diseases and the mechanisms of neuronal cell death....



OPTN

MPPED1 (Metallophosphoesterase Domain Containing 1): MPPED1, while not fully characterized, is believed to be part of the metallophosphoesterase family, suggesting a role in phosphatase activities and metal ion homeostasis. Its expression in the brain indicates potential involvement in neural development and function. The study of MPPED1 may provide insights into neurological processes and disorders, particularly those involving metal ion regulation and phosphatase activities....



MPPED1

MN1 (Meningioma 1): MN1 is associated with the development of meningiomas, a type of brain tumor. It's believed to play a role in the regulation of gene expression and cellular growth. Alterations in MN1 have been implicated in other types of cancers as well....



OR10J1 (Olfactory Receptor 10J1): OR10J1 belongs to the family of olfactory receptors, which are crucial for the sense of smell. This gene encodes receptors that detect specific odor molecules, contributing to the vast array of scent perceptions. Research into this receptor not only enhances our understanding of olfaction but may also provide insights into the development of new sensory-related technologies and fragrance design....



OR10J1

APP (Amyloid Precursor Protein): Much like MMP15's involvement in extracellular matrix (ECM) dynamics, APP plays a pivotal role in regulating cellular processes, particularly in the central nervous system. As a transmembrane protein, APP is involved in various physiological functions, including neuronal development, synaptic plasticity, and cell signaling. Moreover, APP processing yields amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. The balanced regulation of APP processing and amyloid-beta production is crucial for maintaining neuronal homeostasis and cognitive function. Dysregulation of APP processing, leading to abnormal accumulation of amyloid-beta, is a hallmark of Alzheimer's disease pathology. Thus, understanding the...

MON1B (Mon1 Homolog B): MON1B plays a role in intracellular trafficking and autophagy, processes vital for cellular homeostasis and response to stress. It is involved in the regulation of vesicle transport and has implications in neurodegenerative diseases and metabolic disorders....



MON1B

MORC2 (Microrchidia 2): MORC2 is a gene associated with the MORC family of proteins. These proteins have been linked to epigenetic regulation, DNA damage repair, and transcriptional regulation. MORC2's functions are diverse and may impact various cellular processes....



MORC2

OR2B6 belongs to the olfactory receptor (OR) gene family, which is responsible for detecting and recognizing odor molecules in the environment. These receptors are located on the surface of olfactory sensory neurons in the olfactory epithelium of the nasal cavity. One of the primary functions of OR2B6, like other olfactory receptors, is its role in odor detection and olfactory signal transduction. OR2B6 specifically binds to certain odor molecules present in the surrounding air, triggering a signaling cascade within the olfactory sensory neuron. This cascade ultimately leads to the generation of electrical signals that are transmitted to the brain, where they are...



OR2B6

OR10J5 (Olfactory Receptor 10J5): OR10J5 belongs to the family of olfactory receptors, which are crucial for the sense of smell. This gene encodes receptors that detect specific odor molecules, contributing to the vast array of scent perceptions. Research into this receptor not only enhances our understanding of olfaction but may also provide insights into the development of new sensory-related technologies and fragrance design....



OR10J5

OR13F1 (Olfactory Receptor, Family 13, Subfamily F, Member 1): OR13F1 is a member of the olfactory receptor gene family, which are G protein-coupled receptors involved in odor detection. These receptors are expressed in the olfactory epithelium, where they bind specific odor molecules and initiate signal transduction pathways leading to the perception of smell. The specific ligands and functional roles of many olfactory receptors, including OR13F1, remain to be fully elucidated but are essential for our sense of smell and potentially for pheromone detection....



OR13F1

MOV10L1 (Moloney leukemia virus 10-like protein 1): MOV10L1 is a member of the RNA helicase family and plays a significant role in RNA metabolism and post-transcriptional regulation. This protein is involved in various cellular processes, including RNA interference (RNAi), RNA degradation, and mRNA translation. By unwinding RNA duplexes and facilitating the degradation of target RNAs, MOV10L1 influences gene expression and contributes to the regulation of diverse biological pathways. Additionally, MOV10L1 has been implicated in the restriction of retroviruses and retrotransposons, highlighting its role in innate immunity and genome stability. Dysregulation of MOV10L1 expression or function has been associated with several...



MOV10L1

MPZL2 (Myelin Protein Zero-Like 2): MPZL2 is a member of the myelin protein zero (MPZ) family and is involved in the formation and maintenance of myelin in the peripheral nervous system. Myelin is a crucial component for the efficient transmission of nerve impulses. Mutations in genes related to myelin proteins can lead to peripheral neuropathies....



MPZL2

APOE (Apolipoprotein E): APOE, a protein primarily synthesized by the liver and astrocytes in the brain, is crucial for lipid metabolism and transport, particularly in the central nervous system (CNS). It plays a significant role in the clearance of lipoproteins from circulation and the redistribution of cholesterol and other lipids to cells via interactions with cell surface receptors. APOE exists in three common isoforms—APOE2, APOE3, and APOE4—each encoded by a different allele of the APOE gene. These isoforms differ in their affinity for lipoprotein receptors and their subsequent impact on lipid metabolism. APOE4, in particular, has been extensively studied due...

APOE

OR2M3 (Olfactory Receptor, Family 2, Subfamily M, Member 3): OR2M3 belongs to the olfactory receptor gene family, one of the largest gene families in mammals, responsible for the sense of smell. These receptors detect volatile odor compounds and are highly diverse, allowing for the perception of a wide range of smells. OR2M3, like other olfactory receptors, is expressed in the olfactory epithelium of the nose and plays a role in odor detection and signal transduction to the brain. Studies on olfactory receptors like OR2M3 contribute to our understanding of smell and may have implications for flavor science and the development...



OR2M3

MRM2 (Mitochondrial Ribosomal Protein MRP-L23): MRM2 is a gene that codes for a mitochondrial ribosomal protein. These proteins are essential components of the mitochondrial ribosome, which is responsible for synthesizing proteins within the mitochondria. MRM2's role in mitochondrial protein synthesis is crucial for the proper functioning of this organelle and energy production in cells....



MRM2

RPL39 (Mitochondrial Ribosomal Protein L39): MRPL39 is a component of the mitochondrial ribosome, involved in mitochondrial protein synthesis. This protein synthesis is crucial for the production of components of the mitochondrial respiratory chain, essential for cellular energy production. Dysfunctions in MRPL39 can lead to mitochondrial disorders, affecting energy metabolism in cells. The role of MRPL39 in mitochondrial function is critical, as mitochondrial dysfunctions are associated with a wide range of diseases, including neurodegenerative disorders, muscle diseases, and metabolic syndromes....



MRPL39

MRPS18C (Mitochondrial Ribosomal Protein S18C): MRPS18C is part of the mitochondrial ribosome, essential for mitochondrial protein synthesis. It's important for the production of proteins that are part of the mitochondrial respiratory chain. Dysfunctions in MRPS18C can affect mitochondrial function and energy metabolism, potentially leading to mitochondrial disorders....



MRPS18C

OR5H14 (Olfactory Receptor Family 5 Subfamily H Member 14): OR5H14 is part of the olfactory receptor gene family, which is responsible for the sense of smell. These receptors detect and bind specific odor molecules. The specific ligands and functional role of OR5H14 in olfaction are not fully understood, but it contributes to the complex and diverse nature of smell perception....



OR5H14

ORMDO3 (Oligoribonuclease, mitochondrial): Much like MMP15's role in regulating the extracellular matrix (ECM) and tissue integrity, ORMDO3 plays a critical role in maintaining cellular homeostasis within the mitochondria, the powerhouse of the cell. ORMDO3 is an essential enzyme involved in RNA degradation, specifically targeting short RNA fragments within the mitochondria. By facilitating the turnover of mitochondrial RNA molecules, ORMDO3 contributes to the regulation of mitochondrial gene expression and ensures proper mitochondrial function. Dysfunction or dysregulation of ORMDO3 activity can lead to mitochondrial RNA accumulation, impairing mitochondrial function and cellular health. Consequently, abnormalities in ORMDO3 have been associated with various mitochondrial...



ORMDO3

MRPS31 (Mitochondrial Ribosomal Protein S31): MRPS31 is part of the mitochondrial ribosome, involved in mitochondrial protein synthesis. It plays a crucial role in the production of proteins required for mitochondrial function and energy production. Defects in MRPS31 can lead to mitochondrial disorders affecting various body systems....



MRPS31

OR7A17 (Olfactory Receptor, Family 7, Subfamily A, Member 17): OR7A17 is a member of the olfactory receptor gene family, which is involved in the detection of odorants. This large gene family plays a key role in the sense of smell and the complex signaling pathways associated with olfaction....



OR7A17

OR7A5 (Olfactory Receptor, Family 7, Subfamily A, Member 5): Similar to OR7A17, OR7A5 is also an olfactory receptor gene. These receptors are G protein-coupled receptors involved in the detection and discrimination of a wide range of odors, playing a crucial role in the sense of smell....



OR7A5

MRO (Maestro Heat-Like Repeat Family Member): MRO is a protein with a maestro heat-like repeat, suggesting a role in heat shock response or in the cellular response to stress. The specific functions of MRO in human physiology and its involvement in disease processes are not fully understood and represent an area for further research....



OSR1 (Odd-Skipped Related 1): OSR1 is a transcription factor gene playing a key role in embryonic development, especially in the formation of the heart and urogenital system. Mutations or dysregulation of OSR1 can lead to developmental abnormalities in these systems. Research on OSR1 is significant for understanding congenital defects and developmental biology....



OSR1

MROH2A (Maestro Heat-Like Repeat Family Member 2A): MROH2A belongs to a family of proteins characterized by maestro heat-like repeats, which are thought to be involved in lipid metabolic processes. The exact physiological and pathological roles of MROH2A are not well understood, but it may play a role in cellular lipid metabolism, with potential implications for metabolic disorders. Understanding the function of MROH2A could contribute to insights into metabolic regulation and disease mechanisms related to lipid metabolism....



MROH2A

MRPS9 (Mitochondrial Ribosomal Protein S9): MRPS9 is part of the mitochondrial ribosome, essential for mitochondrial protein synthesis. It plays a critical role in the production of proteins necessary for mitochondrial function and energy production. Dysfunctions in MRPS9 can impact mitochondrial efficiency and are potentially linked to mitochondrial disorders, affecting cellular energy metabolism....



MRPS9

OTOP1 (Otopetrin 1): OTOP1 is involved in the function of vestibular systems and is essential for maintaining body balance and spatial orientation. It's implicated in the formation of otoconia, tiny calcium carbonate crystals in the inner ear that are critical for detecting gravity and linear acceleration....



OTOP1

MROH8 (Maestro Heat Like Repeat Family Member 8): MROH8 is a gene that encodes a protein containing heat-like repeat domains, which are involved in protein-protein interactions. The specific function of MROH8 is still under investigation....

MROH8

NCLN (Nicalin): NCLN, known as nicalin, is part of a complex that regulates intracellular signaling pathways crucial for developmental processes. It plays a key role in modulating Notch signaling, a pathway involved in cell differentiation, proliferation, and apoptosis. Dysregulation of NCLN or its associated pathways can lead to developmental abnormalities and has been implicated in various diseases, including cancer. NCLN's function in maintaining cellular communication underscores its importance in development and disease....



NCLN

ORC5 (Origin Recognition Complex Subunit 5): ORC5 is a part of the origin recognition complex, a key element in the initiation of DNA replication in eukaryotic cells. It plays a vital role in ensuring accurate DNA replication, thereby maintaining genomic integrity. Dysfunctions in ORC5 or the replication initiation process can lead to genomic instability, a hallmark of cancerous cells, and contribute to developmental disorders linked to impaired cell proliferation....



ORC5

NCK2 (NCK Adaptor Protein 2): NCK2 is an adaptor protein that plays a key role in linking receptor tyrosine kinases with downstream signaling pathways involved in cell growth, migration, and cytoskeletal reorganization. It participates in various signaling networks that are essential for cellular responses to external stimuli. NCK2 dysregulation has been associated with cancer progression and metastasis, highlighting its importance in cell signaling and tumorigenesis....

NCK2

OTUD1 (OTU Deubiquitinase 1): OTUD1 is a deubiquitinating enzyme involved in the process of removing ubiquitin from ubiquitinated proteins, regulating their degradation, signaling, and other cellular processes. OTUD1 plays a role in the regulation of immune responses and cell signaling pathways by modulating the stability of specific protein targets. Its function in maintaining protein homeostasis and regulating immune signaling highlights its potential importance in immune-related diseases and cancer....



OTUD1

MSRA (Methionine Sulfoxide Reductase A): MSRA is an enzyme that repairs oxidatively damaged proteins by reducing methionine sulfoxide to methionine, helping to protect cells from oxidative stress. Its antioxidant function is crucial in maintaining protein function and cellular health, with implications for aging and diseases related to oxidative damage, including neurodegenerative disorders....



MSRA

ORM1, also known as Orosomucoid 1 or Alpha-1-acid glycoprotein 1, is a glycoprotein primarily synthesized in the liver and secreted into the bloodstream. It belongs to the acute phase reactant proteins, which are produced in response to inflammation, infection, or tissue injury. One of the primary functions of ORM1 is its role in modulating the immune response and inflammation. During acute-phase reactions, the production of ORM1 is upregulated by pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). ORM1 plays a regulatory role in inflammation by binding to various substances, including drugs, hormones, and lipids, and modulating their distribution...



ORM1

NCF4 (Neutrophil Cytosolic Factor 4): NCF4, part of the NADPH oxidase complex, is crucial for the immune defense against pathogens. It regulates the assembly and activation of the NADPH oxidase complex, which produces reactive oxygen species (ROS) as part of the oxidative burst in phagocytes. This process is vital for killing engulfed pathogens. Mutations in NCF4 can lead to immunodeficiencies, characterized by increased susceptibility to infections, highlighting its role in innate immunity and host defense....

NCF4

NCF4 (Neutrophil Cytosolic Factor 4): NCF4 is a component of the NADPH oxidase complex, playing an essential role in the immune defense against pathogens. It participates in the generation of reactive oxygen species in phagocytes, which is crucial for the microbial killing. Mutations in NCF4 have been associated with chronic granulomatous disease, characterized by recurrent bacterial and fungal infections....



MSRB2 (Methionine Sulfoxide Reductase B2): MSRB2 is an enzyme involved in the repair of oxidized methionine residues in proteins, protecting cells from oxidative stress and maintaining protein function. It plays a role in antioxidant defense mechanisms and is important for cellular resilience to environmental stresses. Research into MSRB2 focuses on its potential role in aging, neurodegenerative diseases, and conditions related to oxidative damage....



MSRB2

OVOL1 (Ovo Like Transcriptional Repressor 1): OVOL1 encodes a transcriptional repressor that is involved in the regulation of gene expression during development and tissue differentiation. It plays a role in epithelial cell differentiation and barrier formation....



OVOL1

NCAM1 (Neural Cell Adhesion Molecule 1): NCAM1 plays a pivotal role in neural development, particularly in cell-cell adhesion, neurite outgrowth, and synaptic plasticity. It's important for learning and memory and has been studied in the context of neuropsychiatric disorders, including schizophrenia and autism....



NCAM1

OXTR (Oxytocin Receptor): OXTR is the receptor for oxytocin, a hormone involved in social bonding, sexual reproduction, childbirth, and maternal behaviors. It's significant for behaviors associated with bonding and trust, and dysregulation is implicated in conditions like autism and social anxiety disorders....



OXTR

NBR1 (Neighbor Of BRCA1 Gene 1): NBR1 is a multifunctional autophagy receptor that plays a key role in selective autophagy, a process essential for degrading and recycling cellular components. It is involved in the selective degradation of ubiquitinated protein aggregates and damaged organelles, contributing to cellular homeostasis and protection against stress. NBR1's function in autophagy is linked to its role in disease prevention, including neurodegenerative diseases, cancer, and aging-related disorders, underscoring its importance in cellular health and longevity....

NBR1

NBPF3 (Neuroblastoma Breakpoint Family, Member 3): NBPF3 is a member of the neuroblastoma breakpoint family with a not fully understood function. It may play a role in neurological development or function and could be involved in the pathogenesis of neuroblastoma, a type of childhood cancer....

NBPF3

MST1 (Macrophage Stimulating 1): MST1 encodes a protein involved in the stimulation of macrophages, key cells in the immune system. It plays a role in inflammation and immune response, and is implicated in the pathogenesis of autoimmune diseases and cancer....



MST1

NBDY (NABP Domain Containing): NBDY, also known as C11orf73, is a relatively uncharacterized gene. It contains a domain found in nucleic acid-binding proteins, suggesting a potential role in DNA or RNA metabolism. The specific functions and implications of NBDY in human health and disease are yet to be fully elucidated....

NBDY

NAV3 (Neuron Navigator 3): NAV3 is implicated in neuronal migration and axonal guidance, playing a crucial role in brain development. It is part of the neuron navigator family, which is important for the proper formation of neural networks. Alterations in NAV3 have been linked to a variety of neurological disorders, including Alzheimer's disease and schizophrenia, underscoring its significance in maintaining neural structure and function....

NAV3

MSTN (Myostatin): MSTN encodes myostatin, a protein that acts as a negative regulator of muscle growth and development. Inhibition of myostatin activity is associated with increased muscle mass and strength, making MSTN an attractive target for therapies aimed at promoting muscle growth and treating muscle-wasting conditions....



MSTN

NAV1 (Neuron Navigator 1): NAV1 is a member of the neuron navigator family, involved in neuronal development and axonal guidance. It plays a role in the migration and morphogenesis of neurons, affecting the growth and guidance of axons towards their targets. NAV1's function is essential for the proper wiring of the nervous system, and disruptions in its activity can be linked to neurodevelopmental disorders and may influence recovery processes after nerve injury...


NAV1

NANOS1 (Nanos C2HC-Type Zinc Finger 1): NANOS1 is a post-transcriptional regulator involved in germ cell development. It's essential for the maintenance of germ cell viability and has been studied in relation to infertility and germ cell tumors....

NANOS1

MT1X (Metallothionein 1X): MT1X belongs to the metallothionein family, which plays a significant role in metal ion homeostasis and detoxification, as well as protection against oxidative stress. Metallothioneins bind heavy metals, neutralizing their toxicity and aiding in their metabolism and excretion. MT1X, like other members of this family, is involved in the response to heavy metal exposure, oxidative stress, and inflammation, and has been implicated in various diseases, including cancer, due to its role in cell proliferation and apoptosis....



MT1X

P2RY1 (Purinergic Receptor P2Y1): P2RY1 is a G-protein coupled receptor that responds to extracellular nucleotides, such as ATP and ADP, playing a critical role in intracellular signaling pathways involved in platelet aggregation, vascular tone, and neurotransmission. Activation of P2RY1 is crucial for initiating the platelet aggregation response to vessel injury, implicating its significance in thrombosis and hemostasis. Dysregulation of P2RY1 signaling is linked to increased risk of cardiovascular diseases, emphasizing its role in vascular health....



P2RY1

NADSYN1 (NAD Synthetase 1): NADSYN1 is involved in the synthesis of NAD (nicotinamide adenine dinucleotide), a vital coenzyme in redox reactions. This gene's function is essential in various metabolic processes, and its role is increasingly recognized in the context of aging, cell death, and certain chronic diseases....

NADSYN1

MTAP (Methylthioadenosine Phosphorylase): MTAP plays a role in the methionine salvage pathway, recycling methylthioadenosine produced during polyamine synthesis. Its function is critical for nucleotide and polyamine metabolism, affecting cell growth and differentiation. Loss of MTAP is frequently observed in cancers and is associated with poor prognosis, highlighting its potential as a therapeutic target due to its role in metabolic pathways critical for cell viability....



MTAP

P2RY12 (Purinergic Receptor P2Y12): P2RY12 is a receptor for ADP and plays a key role in platelet aggregation, a crucial step in blood clot formation. It is a target for antiplatelet drugs, which are used to prevent thrombosis in cardiovascular diseases. Understanding P2RY12 is important for cardiovascular health and in the management of clotting disorders....



P2RY12

MTARC1 (Mitochondrial Amidoxime Reducing Component 1): MTARC1 is a mitochondrial gene involved in the reduction of N-hydroxylated compounds, a process important for detoxification. It plays a role in cellular metabolism and energy production. Alterations in MTARC1 can affect mitochondrial function, which is crucial for energy production in cells. Research into MTARC1 is important for understanding metabolic disorders and mitochondrial diseases....



MTARC1

NAA38 (N(Alpha)-Acetyltransferase 38): NAA38, also known as N(Alpha)-acetyltransferase 38, is involved in the post-translational modification of proteins, specifically in the acetylation of the alpha-amino group of newly synthesized proteins. This modification affects protein stability, localization, and function. NAA38 plays a role in various cellular processes, including the regulation of gene expression and the stress response. Alterations in NAA38 activity have been linked to metabolic disorders and neurodegenerative diseases, emphasizing its importance in cellular metabolism and homeostasis....


NAA38

PACC1 (Peroxisome Acyl-CoA Carrier Protein 1): PACC1, while less characterized, is suggested to be involved in lipid metabolism pathways related to peroxisomal functions. Peroxisomes are cellular organelles crucial for the breakdown of very long-chain fatty acids and the synthesis of plasmalogens, important components of cell membranes. Understanding PACC1's role may provide insights into metabolic diseases and disorders involving peroxisomal dysfunction....



PACC1

MYRIP (Myosin VIIA And Rab Interacting Protein): MYRIP is involved in the transport and localization of melanosomes in pigment cells and synaptic vesicles in neuronal cells. It facilitates the linkage between actin-based myosin VIIA and Rab proteins, crucial in vesicle trafficking. This function is important for processes such as pigmentation and synaptic transmission....

MYRIP

MTCH2 (Mitochondrial Carrier Homolog 2): MTCH2 is a gene associated with mitochondrial function and energy metabolism. It may play a role in mitochondrial transport and metabolism. Further research is needed to fully understand its function and implications....



MTCH2

PAFAH1B2 (Platelet-Activating Factor Acetylhydrolase 1B, Subunit 2): PAFAH1B2 is involved in the metabolism of platelet-activating factor, a lipid mediator in inflammation. It plays a role in modulating inflammatory responses and may have implications in cardiovascular diseases and immune system functioning....



PAFAH1B2

MYPOP (Myb-related transcription factor partner): Similar to MMP15's role in the extracellular matrix (ECM), MYPOP serves as a crucial regulator within the intricate network of transcriptional control. As a partner to Myb-related transcription factors, MYPOP plays a vital role in modulating gene expression patterns essential for various cellular processes, including proliferation, differentiation, and cell cycle progression. Through its involvement in transcriptional regulation, MYPOP influences diverse physiological phenomena, such as tissue development, immune response, and homeostasis maintenance. Dysregulation of MYPOP expression or activity has been implicated in numerous pathological conditions, including cancer, developmental disorders, and immune-related diseases. The precise orchestration of...

MYPOP

MTDH (Metadherin): MTDH, also known as AEG-1, is a multifunctional protein implicated in several key cellular processes, including cell adhesion, migration, and oncogenesis. It is heavily involved in the development and progression of various cancers, acting as an oncogene by promoting tumor growth, angiogenesis, and metastasis. MTDH is a target for cancer therapy due to its role in enhancing chemoresistance and its association with poor clinical prognosis in cancer patients....



MTDH

PALM (Paralemmin): PALM is involved in neuronal plasticity, membrane trafficking, and cytoskeletal dynamics. It plays a role in the formation and maintenance of dendritic spines, which are essential for synaptic signaling in neurons....



PALM

MYOM1 (Myomesin 1): MYOM1 is a structural protein found in the M-band of sarcomeres in muscle cells. It plays a crucial role in muscle contraction and elasticity. Mutations in MYOM1 can affect muscle function and have been studied in the context of muscle diseases and cardiomyopathies....

MYOM1

CXCR2 (C-X-C Motif Chemokine Receptor 2): CXCR2 is a receptor for C-X-C motif chemokines and plays a significant role in mediating leukocyte migration to sites of inflammation. It is primarily involved in the recruitment of neutrophils, critical for the initial response to infection or injury. Dysregulation of CXCR2 signaling is associated with chronic inflammatory diseases, including COPD and asthma, and contributes to the inflammatory microenvironment favorable for tumor growth in cancer. Targeting CXCR2 signaling represents a therapeutic strategy in treating inflammatory diseases and limiting cancer progression....

CXCR2

MTHFD1 (Methylenetetrahydrofolate Dehydrogenase 1): MTHFD1 is a key enzyme in the folate metabolism pathway, catalyzing the conversion of tetrahydrofolate (THF) derivatives into forms used in the synthesis of DNA, RNA, and amino acids. It plays a crucial role in the one-carbon metabolism pathway, affecting cellular methylation reactions and nucleotide biosynthesis. Mutations or dysregulation of MTHFD1 can lead to disturbances in folate metabolism, associated with increased risk of congenital defects, cardiovascular diseases, and cancer, highlighting its pivotal role in cellular growth and replication processes....





MTHFD1

MTHFD2 (Methylenetetrahydrofolate Dehydrogenase 2): MTHFD2 is an enzyme that plays a vital role in the mitochondrial one-carbon metabolic pathway, crucial for nucleotide biosynthesis, methylation reactions, and amino acid homeostasis. This enzyme is highly expressed in rapidly dividing cells, including cancer cells, where it contributes to the synthesis of purines and thymidylate, essential for DNA replication and repair. MTHFD2's involvement in cellular metabolism and proliferation highlights its importance in developmental processes and cellular growth. Due to its pivotal role in supporting the metabolic demands of tumor growth and its limited expression in normal adult tissues, MTHFD2 has emerged as a potential...



MTHFD2

PAM (Peptidylglycine Alpha-Amidating Monooxygenase): PAM encodes an enzyme involved in the amidation of peptide hormones, a critical step in the maturation of neuropeptides and peptide hormones. It plays a role in neurotransmitter synthesis and hormone production. Dysregulation of PAM can impact neuropeptide function and hormonal signaling....



PAPLN (Pappalysin 1): PAPLN is a gene associated with pregnancy-associated plasma protein-A (PAPP-A), which is involved in pregnancy-related processes. PAPP-A plays a role in the regulation of insulin-like growth factor (IGF) signaling....



PAPLN

PAPPA (Pregnancy-Associated Plasma Protein A): PAPPA is a protease that cleaves insulin-like growth factor binding proteins, thereby increasing the availability of insulin-like growth factors (IGFs). It plays a significant role in fetal development and has been used as a biomarker in prenatal screening for aneuploidies. Abnormal levels of PAPPA are associated with adverse pregnancy outcomes, including preeclampsia and intrauterine growth restriction....



PAPPA

MTHFR (Methylenetetrahydrofolate Reductase): MTHFR is a key enzyme involved in folate metabolism and the regulation of homocysteine levels in the body. This enzyme catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a crucial step in the remethylation of homocysteine to methionine. Methionine serves as a precursor for S-adenosylmethionine (SAM), a methyl donor essential for numerous methylation reactions in the body, including DNA methylation, neurotransmitter synthesis, and histone modification. Variants in the MTHFR gene, particularly the C677T and A1298C polymorphisms, have been associated with altered enzyme activity and folate metabolism. These variants can lead to elevated homocysteine levels and reduced availability of methyl...



MTHFR

MTMR7 (Myotubularin Related Protein 7): MTMR7 is part of the myotubularin family, enzymes involved in the regulation of cellular lipid levels, specifically phosphoinositides. This gene plays a role in intracellular signaling and trafficking. Mutations or dysregulation of MTMR7 can impact cellular processes like autophagy and endocytosis, and have been studied in the context of neurodegenerative diseases....



MTMR7

PAPSS2 (3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2): PAPSS2 is essential for the biosynthesis of PAPS (3'-phosphoadenosine 5'-phosphosulfate), a key sulfate donor in various sulfation reactions. It's important in the metabolism of hormones, drugs, and other molecules. Mutations in PAPSS2 can lead to disorders like spondyloepimetaphyseal dysplasia, underscoring its role in skeletal development....



PAPSS2

PARD3B (Par-3 Family Cell Polarity Regulator Beta): PARD3B is involved in the establishment of cell polarity and the formation of tight junctions in epithelial cells. It plays a crucial role in tissue organization and barrier function. Mutations in PARD3B can lead to developmental disorders affecting tissue structure and integrity....



PARD3B

MTNR1B (Melatonin Receptor 1B): MTNR1B encodes one of the receptors for melatonin, a hormone that regulates sleep and circadian rhythms. This gene plays a crucial role in maintaining the body's internal clock and is also implicated in glucose homeostasis. Variations in MTNR1B have been linked to an increased risk of type 2 diabetes and disrupted sleep patterns....



MTNR1B

BANK1, also known as B-cell scaffold protein with ankyrin repeats 1, is a protein predominantly expressed in B lymphocytes, a type of white blood cell crucial for adaptive immunity. BANK1 plays a significant role in modulating B-cell receptor (BCR) signaling, a pivotal process in the activation and differentiation of B cells. One of the primary functions of BANK1 is its involvement in BCR signaling pathway regulation. BANK1 acts as a scaffold protein, facilitating the assembly of signaling complexes upon BCR engagement. It interacts with various signaling molecules, including kinases, phosphatases, and adapter proteins, thereby modulating downstream signaling cascades. Through its scaffolding...




BANK1

MTX1 (Metaxin 1): MTX1 encodes a protein involved in mitochondrial transport and organization. It plays a role in the proper functioning and positioning of mitochondria within cells, which is crucial for energy production and cellular processes....



MTX1

MUC1 (Mucin 1): MUC1 encodes a glycoprotein found on the surface of various epithelial cells, including those lining the respiratory and digestive tracts. It serves protective and lubricating functions and is involved in cell signaling. Aberrant expression of MUC1 is associated with several cancers....



MUC1

PDE3B (Phosphodiesterase 3B): PDE3B is important in regulating lipid and glucose metabolism. It plays a role in breaking down cyclic AMP, a messenger molecule, which affects processes like lipolysis and insulin secretion. It has implications in metabolic disorders such as obesity and diabetes....



PDE3B

MXRA8 (Matrix Remodeling-Associated Protein 8): MXRA8 is a gene associated with matrix remodeling, a vital process in tissue development and repair. While its specific roles are still being explored, MXRA8's involvement in extracellular matrix interactions suggests potential contributions to tissue homeostasis and regeneration. Understanding its functions may hold implications for tissue engineering and regenerative medicine....



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