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Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

<p>Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.</p>

DNA Fatigue Test

GetTested’s DNA Brain Health test provides a detailed genetic analysis of 288 genes to understand factors that affect your mental health. This at-home test examines specific genes related to memory, stress management, anxiety susceptibility, and mood swings, offering a comprehensive insight into how your unique genetic makeup impacts your mental well-being.

<p>GetTested’s DNA Brain Health test provides a detailed genetic analysis of 288 genes to understand factors that affect your mental health. This at-home test examines specific genes related to memory, stress management, anxiety susceptibility, and mood swings, offering a comprehensive insight into how your unique genetic makeup impacts your mental well-being.</p>

DNA Brain Health Test

ASPRV1 (Aspartic Peptidase, Retroviral-Like 1): ASPRV1 is a gene that encodes an aspartic peptidase enzyme. The specific function of ASPRV1 is still being investigated, but it may play a role in proteolytic processes within cells. Further research is needed to fully understand its function and implications....

ASPRV1

ASTN2 (Astrotactin 2): ASTN2 is a neural adhesion protein involved in neuronal migration in the developing brain. It's crucial for the proper formation of neural networks and brain structure. Genetic variations in ASTN2 have been linked to neurological disorders, including autism spectrum disorders and attention deficit hyperactivity disorder (ADHD)....

ASTN2

ATF7 (Activating Transcription Factor 7): ATF7 is a member of the ATF/CREB family of transcription factors and plays a pivotal role in cellular stress response, apoptosis, and development. It regulates the expression of genes involved in response to cellular stressors and contributes to neuronal differentiation and survival. Dysregulation of ATF7 activity has been linked to various stress-related conditions, including neurodegenerative diseases and cancer, underscoring its importance in maintaining cellular homeostasis and response to damage....

ATF7

ATG12 (Autophagy Related 12): ATG12 is a key gene involved in the process of autophagy, a cellular mechanism for degrading and recycling cellular components. This gene plays a crucial role in cellular maintenance and survival, particularly under stress conditions. It's involved in the formation of a conjugate with ATG5, which is essential for the autophagosome formation, a pivotal step in the autophagy pathway. Dysregulation of ATG12 has been linked to various diseases, including cancer and neurodegenerative disorders....




ATG12

ATP10B (ATPase Phospholipid Transporting 10B): ATP10B is a member of the P-type ATPases, involved in transporting lipids across cellular membranes. Its specific role is less understood, but it may be significant in lipid metabolism and cellular homeostasis, with potential implications for neurodegenerative diseases like Parkinson’s....




ATP10B

ATP1B2, also known as Sodium/potassium-transporting ATPase subunit beta-2, is a protein that serves as a subunit of the sodium-potassium ATPase (Na+/K+-ATPase) pump. This pump is crucial for maintaining the electrochemical gradients of sodium and potassium ions across cell membranes, a process essential for numerous physiological functions, including nerve conduction, muscle contraction, and regulation of cell volume. As a subunit of the Na+/K+-ATPase pump, ATP1B2 plays an indispensable role in the assembly, stability, and function of the pump complex. It interacts with the catalytic alpha subunit of the pump, ATP1A1 or ATP1A2, and helps to anchor the complex to the cell membrane....

ATP1B2

ATP1B3 (ATPase Na+/K+ Transporting Subunit Beta 3): ATP1B3 is part of the Na+/K+ ATPase pump, which is essential for maintaining cellular ion gradients, a critical process for cell volume regulation and electrical excitability. This subunit helps regulate the pump's activity and specificity, contributing to its role in muscle function, nerve transmission, and kidney filtration. Dysregulation or mutations in ATP1B3 have potential implications for cardiovascular diseases and neurological disorders....

ATP1B3

ATP2B2 (ATPase Plasma Membrane Ca2+ Transporting 2): ATP2B2 encodes a calcium pump involved in the regulation of intracellular calcium levels, crucial for a wide range of cellular processes, including signal transduction, muscle contraction, and neurotransmitter release. Mutations in ATP2B2 have been linked to deafness and vestibular disorders, underscoring its role in hearing and balance through the regulation of calcium in sensory hair cells....

ATP2B2

ATP2B4 (ATPase Plasma Membrane Ca2+ Transporting 4): ATP2B4 encodes a calcium pump responsible for the removal of calcium from cells. It plays a key role in intracellular calcium homeostasis, affecting muscle contraction, cell signaling, and neuronal activity. Dysregulation of ATP2B4 is implicated in cardiovascular diseases....

ATP2B4

ATP5MK (ATP Synthase Membrane Subunit K): ATP5MK is part of the mitochondrial ATP synthase complex, which is crucial for ATP production in cellular respiration. It plays a role in the energy metabolism of cells, and dysfunctions in ATP5MK can affect cellular energy levels, potentially contributing to metabolic disorders....

ATP5MK

ATP5PD (ATP Synthase Peripheral Stalk Subunit DAPIT): ATP5PD is a component of the mitochondrial ATP synthase, playing a role in cellular energy production. It is involved in the synthesis of ATP, the primary energy carrier in cells, and is crucial for maintaining mitochondrial function and overall cellular metabolism....




ATP5PD

ATP8B1 (ATPase Phospholipid Transporting 8B1): ATP8B1 is a gene that encodes a phospholipid transporter located in the liver cell membrane. It plays a crucial role in maintaining the lipid composition of cell membranes and bile. Mutations in ATP8B1 can result in progressive familial intrahepatic cholestasis (PFIC), a group of liver disorders....

ATP8B1

ATP8B2 (ATPase Phospholipid Transporting 8B2): ATP8B2 is a gene associated with an ATPase enzyme that transports phospholipids across cell membranes. Phospholipid transport is critical for maintaining membrane integrity and cellular homeostasis. ATP8B2 likely participates in the regulation of lipid composition in cell membranes....




ATP8B2

ATP9A (ATPase Phospholipid Transporting 9A): ATP9A is involved in the transport of phospholipids across cellular membranes, playing a key role in membrane trafficking and phospholipid homeostasis. It is important for cell growth, division, and differentiation. Dysregulation of ATP9A has been implicated in neurological disorders, highlighting its importance in maintaining cellular membrane composition and function....

ATP9A

ATXN1 (Ataxin 1): ATXN1 encodes a protein called ataxin-1, which is involved in neuronal function. Mutations in this gene, particularly expanded CAG repeats, cause spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder characterized by loss of motor coordination and balance. Research into ATXN1 is crucial for understanding and developing treatments for this and similar neurodegenerative diseases....

ATXN1

AUTS2 (Activator Of Transcription And Developmental Regulator AUTS2): AUTS2 is implicated in neurodevelopment and is associated with autism spectrum disorder and intellectual disability. It plays a role in gene regulation and brain development, with mutations affecting neural development and function....

AUTS2

AXIN2 (Axin 2): AXIN2 is a crucial component of the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and embryonic development. AXIN2 acts as a negative regulator of Wnt signaling, and mutations in this gene are associated with various cancers and developmental disorders, including colorectal cancer and tooth agenesis....

AXIN2

AZIN2 (Antizyme Inhibitor 2): AZIN2 regulates the activity of ornithine decarboxylase, a key enzyme in polyamine biosynthesis which is important for cell growth and differentiation. It acts by inhibiting antizyme, which usually downregulates ornithine decarboxylase. Abnormalities in polyamine metabolism, potentially influenced by AZIN2, have been associated with cancer, as polyamines are critical for cell proliferation....

AZIN2

B3GALNT1 (Beta-1,3-N-Acetylgalactosaminyltransferase 1): B3GALNT1 is involved in glycosylation, a process essential for the proper function of many proteins. It synthesizes a type of glycan structure important for cell-cell adhesion and signaling. Mutations in B3GALNT1 can lead to muscular dystrophy-dystroglycanopathy, a group of disorders affecting muscle function....

B3GALNT1

B3GNTL1 (Beta-1,3-N-Acetylglucosaminyltransferase Like 1): B3GNTL1 is involved in the biosynthesis of complex carbohydrates, specifically in the formation of glycosaminoglycans, which are components of the extracellular matrix. While the detailed biological functions of B3GNTL1 are still being elucidated, enzymes involved in carbohydrate modification are crucial for cell-cell communication, signaling, and structural integrity. Aberrations in glycosaminoglycan synthesis can have implications for developmental processes and diseases such as cancer and congenital disorders....

B3GNTL1

B4GALT6, also known as Beta-1,4-galactosyltransferase 6, is a key enzyme involved in the biosynthesis of complex carbohydrates known as glycosaminoglycans (GAGs). Positioned primarily within the Golgi apparatus of cells, B4GALT6 plays a crucial role in catalyzing the transfer of galactose residues from UDP-galactose to acceptor substrates, leading to the formation of specific glycosidic linkages. One of the primary functions of B4GALT6 is its involvement in the biosynthesis of proteoglycans, a class of glycoproteins containing GAG chains. Specifically, B4GALT6 catalyzes the addition of galactose residues to the core protein structure of proteoglycans, initiating the assembly of GAG chains such as chondroitin sulfate...

B4GALT6

BACH2 (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2): BACH2 encodes a transcription factor involved in regulating immune responses. It plays a crucial role in maintaining immune homeostasis by controlling the differentiation and function of various immune cells, including B cells and T cells. Dysregulation of BACH2 has been associated with autoimmune diseases and susceptibility to infections....

BACH2

BAIAP2L1, also known as Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, is a protein encoded by the BAIAP2L1 gene. It belongs to the I-BAR domain-containing protein family and is involved in various cellular processes, including actin cytoskeleton remodeling, membrane dynamics, and cell signaling. One of the primary functions of BAIAP2L1 is its role in regulating actin dynamics and cytoskeletal organization. It contains an I-BAR (inverse Bin-Amphiphysin-Rvs) domain, which allows it to bind to and induce curvature in membranes, particularly at sites of membrane protrusions such as filopodia and lamellipodia. Through its ability to interact with actin filaments and membrane phospholipids,...




BAIAP2L1

BARHL2 (BarH-Like Homeobox 2): BARHL2 is a homeobox transcription factor that plays a crucial role in neural development. It is involved in the differentiation and specification of specific neuronal cell types during embryonic development, contributing to the formation of a functional nervous system....



BARHL2

BBX (Bobby Sox Homolog): BBX is a transcriptional regulator involved in cell proliferation and differentiation. It plays a crucial role in embryonic development and has been implicated in regulating circadian rhythms. Disruptions in BBX function can lead to developmental abnormalities and impact circadian behavior....



BCAT1 (Branched Chain Amino Acid Transaminase 1): BCAT1 is a pivotal enzyme in the metabolism of branched-chain amino acids (BCAAs), which include leucine, isoleucine, and valine. Located primarily in the cytosol of tissues such as the brain and in various tumors, BCAT1 catalyzes the reversible transamination of BCAAs to their corresponding α-keto acids, initiating their catabolic pathway. This enzyme plays an essential role in nitrogen homeostasis and the synthesis of neurotransmitters in the brain, influencing cognitive functions and neurodevelopment. Beyond its metabolic functions, BCAT1 is implicated in the proliferation and metabolism of cancer cells, highlighting its potential as a biomarker...



BCAT1

BCL11A (B-Cell CLL/Lymphoma 11A): BCL11A is a transcription factor critical in the development and functioning of blood cells. It plays a significant role in the regulation of fetal hemoglobin levels and has been a focus in studies related to sickle cell disease and beta-thalassemia. BCL11A is also implicated in various hematological cancers....



BCL11A

BCL11B (B-Cell CLL/Lymphoma 11B): BCL11B is a transcription factor that plays a critical role in the development and differentiation of T-cells. It is also involved in neuronal development. Mutations or dysregulation in BCL11B have been linked to various types of hematological malignancies, including T-cell acute lymphoblastic leukemia, and to neurodevelopmental disorders....



BCL11B

BCL2L1 (BCL2 Like 1): BCL2L1, also known as Bcl-xL, is a member of the Bcl-2 protein family that plays a pivotal role in the regulation of apoptosis, or programmed cell death. By inhibiting the release of pro-apoptotic factors from mitochondria, BCL2L1 promotes cell survival and is crucial for maintaining cellular integrity under stress conditions. It is expressed in a variety of tissues and is involved in the development and progression of diseases, including cancer, by helping cancer cells evade apoptosis. The overexpression of BCL2L1 has been associated with resistance to chemotherapy and poor prognosis in various types of cancer....



BCL2L1

BCO1 (Beta-Carotene Oxygenase 1): BCO1 is responsible for the conversion of beta-carotene to retinal, a form of vitamin A, which is essential for vision, immune function, and cellular communication. This gene's activity influences how efficiently dietary beta-carotene is converted into vitamin A, impacting vitamin A status and related health outcomes. Variations in BCO1 can affect an individual's response to dietary beta-carotene and risk of vitamin A deficiency....



BCO1

BDNF (Brain-Derived Neurotrophic Factor): BDNF is a gene that encodes a protein called brain-derived neurotrophic factor, which is crucial for the survival and growth of neurons in the brain. BDNF plays a key role in synaptic plasticity, learning, and memory. Dysregulation of BDNF has been linked to various neurological and psychiatric disorders....



BDNF

BEND5 (BEN Domain Containing 5): BEND5 is a gene that is relatively less understood but is thought to be involved in chromatin organization and gene regulation. The BEN domain suggests a role in DNA binding and transcriptional regulation. Research is ongoing to elucidate its specific functions and its implications in cellular processes and diseases....



BEND5

BET1L (Bet1 Golgi Vesicular Membrane Trafficking Protein-Like): BET1L plays a crucial role in the vesicular transport system, specifically in the trafficking between the endoplasmic reticulum and the Golgi apparatus. This process is fundamental for the proper secretion and processing of proteins, which is essential for various cellular functions, including cell signaling, metabolism, and maintenance of cell structure. BET1L's role in this transport system makes it critical for normal cellular operation and the maintenance of cellular homeostasis....



BET1L

BHLHE40 (Basic Helix-Loop-Helix Family Member E40): BHLHE40 is a gene that encodes a transcription factor involved in circadian rhythm regulation. It plays a role in the control of the sleep-wake cycle and the expression of circadian clock genes. Dysregulation of BHLHE40 can impact circadian rhythms and sleep patterns....



BHLHE40

BHMT2 (Betaine-Homocysteine S-Methyltransferase 2) functions similarly to its counterpart, BHMT, in homocysteine metabolism, crucial for cardiovascular and neurological well-being. It assists in converting homocysteine to methionine, albeit less extensively studied than BHMT. This gene's activity impacts homocysteine levels in the body, with potential implications for heart health and neurological conditions. Understanding BHMT2's role could further clarify its contribution to metabolic pathways and disease risk....



BHMT2

BIN1 (Bridging Integrator 1): BIN1 is a protein that is essential for cellular membrane dynamics. It is involved in processes such as endocytosis and membrane curvature. BIN1 acts as a bridging factor and plays a critical role in facilitating membrane invaginations called tubules, which are essential for various cellular functions....



BIN1

FANCI (FA Complementation Group I): FANCI is part of the Fanconi anemia (FA) pathway, crucial for DNA repair. It plays a role in the response to DNA damage and is important for maintaining genomic stability. Mutations in FANCI can cause Fanconi anemia, a disorder characterized by bone marrow failure, cancer susceptibility, and developmental abnormalities....

FANCI

FAP (Fibroblast Activation Protein Alpha): FAP encodes an enzyme known as fibroblast activation protein alpha, which is expressed by activated fibroblasts in the tumor microenvironment. It plays a role in tissue remodeling and is a potential therapeutic target in cancer treatment....

FAR1 (Fatty Acyl-CoA Reductase 1): FAR1 is involved in the synthesis of fatty alcohols from fatty acyl-CoA substrates, a key step in the production of wax esters and other complex lipids. These lipids are essential components of cell membranes and are involved in protecting cells against environmental stress. FAR1's role in lipid metabolism has implications for skin barrier function, lipid storage diseases, and the development of biofuels and industrial chemicals....

FAR1

FARP2 (FERM, ARH/RhoGEF, And Pleckstrin Domain Protein 2): FARP2 is a signaling protein that influences neuronal development and synaptic plasticity by regulating dendritic spine formation and actin cytoskeleton remodeling. It acts as a guanine nucleotide exchange factor for small GTPases, mediating cell signaling pathways that affect neuronal connectivity and function. Alterations in FARP2 expression or function are associated with neurological disorders, highlighting its significance in brain development and synaptic regulation....

FARP2

FARSA (Phenylalanyl-tRNA Synthetase Subunit Alpha): FARSA is involved in the translation process of protein synthesis, specifically in attaching phenylalanine to its corresponding tRNA. This function is essential for the accurate translation of mRNA into proteins. Mutations in FARSA or dysregulation of its activity can lead to errors in protein synthesis, potentially causing a range of cellular dysfunctions and contributing to disease processes....

FARSA

FBH1 (F-Box DNA Helicase 1): FBH1, also known as FBD4, encodes a DNA helicase involved in DNA repair and replication. It plays a role in maintaining genomic stability and preventing DNA damage accumulation. Dysfunctions in FBH1 can lead to genomic instability, a hallmark of cancer, making it important in cancer biology and the study of DNA repair mechanisms....

FBH1 (FBD4)

FBLL1 (Fibroblast-Like Protein 1): FBLL1, a member of the fibroblast-like protein family, serves as a pivotal player in orchestrating cellular interactions within the extracellular matrix (ECM). Through its regulatory functions, FBLL1 exerts a profound influence on diverse physiological processes, encompassing tissue regeneration, vascular development, and embryogenesis, by modulating ECM composition and architecture. The finely tuned activity of FBLL1 is indispensable for the maintenance of tissue homeostasis and repair mechanisms. However, aberrant expression or dysregulation of FBLL1 has been implicated in the pathogenesis of several disorders, including cancer progression, tissue fibrosis, and inflammatory conditions. Understanding the intricate control of FBLL1 activity...

FBLL1

FBLN5 (Fibulin 5): FBLN5 is involved in elastic fiber assembly and connective tissue organization, playing a crucial role in maintaining the integrity and elasticity of extracellular matrix. It is essential for skin, vascular, and lung function. Dysregulation of FBLN5 is associated with tissue stiffness, age-related macular degeneration, and organ fibrosis, highlighting its importance in tissue remodeling and disease....

FBLN5

FBXO24 (F-Box Protein 24): FBXO24 is part of the F-box protein family, which plays a role in protein degradation via the ubiquitin-proteasome system. It is involved in cell cycle regulation and protein turnover, but its specific physiological functions and implications in diseases are not fully elucidated....

FBXO24

FBXO8 (F-Box Protein 8): FBXO8 is part of the F-box family of proteins, which play critical roles in the ubiquitin-proteasome pathway, a system crucial for protein degradation and turnover in cells. As an F-box protein, FBXO8 is likely involved in targeting specific proteins for degradation, thereby regulating various cellular processes including cell cycle, signal transduction, and immune responses. The exact substrates and physiological functions of FBXO8 are not fully understood, but its involvement in protein degradation suggests its potential impact on cellular homeostasis and disease states, particularly in conditions where protein aggregation or misfolding is a concern, such as neurodegenerative...

FBXO8

FCER1G (Fc Epsilon Receptor I Gamma): FCER1G is an important component of the high affinity receptor for the Fc region of immunoglobulin E (IgE). It plays a critical role in allergic responses and is involved in the activation of mast cells and basophils. Alterations in this gene can influence the severity and susceptibility to allergic diseases and asthma....

FCER1G

SETBP1 (SET Binding Protein 1): SETBP1 is a protein that interacts with SET, a regulator of histone acetylation and chromatin remodeling. SETBP1 plays a role in gene regulation and has been associated with developmental disorders and leukemia....

SETBP1

FCGR3A (Fc Fragment Of IgG Receptor IIIa): FCGR3A, also known as CD16a, is a receptor for the Fc portion of immunoglobulin G (IgG) and plays a key role in immune response by mediating antibody-dependent cellular cytotoxicity (ADCC). It is expressed on natural killer (NK) cells, macrophages, and some T cells, facilitating the clearance of pathogens and antibody-coated cells. Variations in FCGR3A have been associated with susceptibility to autoimmune diseases and response to immunotherapy in cancer treatment....

FCGR3A

FCHO2 (FCH Domain Only 2): FCHO2 is involved in the process of clathrin-mediated endocytosis, a key mechanism for internalizing substances from the cell surface. It plays a role in vesicle formation and trafficking within cells. Dysregulation of FCHO2 can affect cellular uptake processes and has potential implications in various cellular dysfunctions....

FCHO2

SETD7 (SET Domain Containing 7, Lysine Methyltransferase): SETD7 is involved in epigenetic regulation as it encodes an enzyme responsible for methylation of histone proteins. This methylation is crucial for regulating gene expression. Dysregulation of SETD7 activity is associated with various pathological conditions, including cancer and cardiovascular diseases....



SETD7

SFTPA1 (Surfactant Protein A1): SFTPA1 encodes a protein crucial in lung function, particularly in the innate immune response of the respiratory tract. It helps in reducing surface tension in the lungs and plays a role in defending against respiratory pathogens. Mutations in SFTPA1 are associated with respiratory diseases....



SFTPA1

FCHSD2 (FCH And Double SH3 Domains 2): FCHSD2 is involved in cellular processes like endocytosis and cytoskeletal organization. It's notable for its role in vesicle transport and has been linked to certain cancers. Its function in cell signaling and membrane dynamics makes it relevant in understanding cellular communication and disease mechanisms....

FCHSD2

FBXL17 (F-Box and Leucine-Rich Repeat Protein 17): FBXL17 is a member of the F-box protein family, which are critical components of the SCF (SKP1-cullin-F-box) complex, responsible for the ubiquitination and subsequent proteasomal degradation of target proteins. Through its role in protein turnover, FBXL17 regulates various cellular processes including cell cycle progression, signal transduction, and transcription. Its specific function involves the recognition and binding of phosphorylated substrates via its F-box motif and leucine-rich repeats, targeting them for ubiquitination. The precise regulation of protein levels by FBXL17 is essential for maintaining cellular homeostasis and function. Dysregulation of FBXL17 activity has been linked...

FBXL17

FBXO21 (F-Box Protein 21): FBXO21 is part of the F-box protein family, key components in the ubiquitin-proteasome system, which regulates protein degradation. This gene plays a crucial role in various cellular processes, including cell cycle regulation and signal transduction. Dysregulation of FBXO21 can lead to disorders in protein homeostasis, making it significant in the study of diseases where protein turnover is disrupted, such as neurodegenerative diseases and cancers....

FBXO21

FCRL3 (Fc Receptor-Like 3): FCRL3 is a member of the Fc receptor-like (FCRL) gene family and is primarily expressed in B cells. It is involved in modulating B cell receptor signaling and antibody production. FCRL3 may play a role in regulating immune responses and autoimmune diseases....

FCRL3

FCRL6 (Fc Receptor-Like 6): FCRL6 is involved in the immune system's regulation, expressed on certain T cells and natural killer (NK) cells. It plays a role in modulating immune responses, potentially influencing the activity of these cells in infection, autoimmune diseases, and cancer. The study of FCRL6 aims to uncover novel therapeutic targets for enhancing immune regulation....

FCRL6

SGCD (Sarcoglycan Delta): SGCD is part of the dystrophin-glycoprotein complex, crucial for muscle integrity and function. Mutations in SGCD are associated with limb-girdle muscular dystrophy, a group of genetic disorders that weaken and waste the muscles around the hips and shoulders....



SGCD

FDX1 (Ferredoxin 1): FDX1 plays a crucial role in mitochondrial electron transport, facilitating the transfer of electrons in various metabolic processes, including steroid hormone biosynthesis and detoxification reactions. It is a key component in the synthesis of iron-sulfur clusters, essential cofactors for many enzymes. Dysregulation of FDX1 has implications for energy metabolism and has been explored in the context of diseases related to mitochondrial function....

FDX1

SGK1 (Serum/Glucocorticoid Regulated Kinase 1): SGK1 is a serine/threonine kinase regulated by glucocorticoids and involved in cell survival, ion transport, and metabolic processes. It plays a role in responding to stress and in the regulation of ion channels, particularly in the kidneys, affecting sodium and water balance. Dysregulation of SGK1 has implications in hypertension, diabetic nephropathy, and could contribute to the development of certain cancers....



SGK1

SH2B3 (SH2B Adaptor Protein 3): SH2B3, also known as LNK, is an adaptor protein that negatively regulates cytokine signaling in hematopoietic cells. It plays a crucial role in maintaining hematopoietic stem cell homeostasis and regulating immune responses. SH2B3 mutations are associated with a variety of hematologic disorders, including myeloproliferative neoplasms and autoimmune diseases, underscoring its importance in blood cell development and immune regulation....



SH2B3

FERD3L (Fer3-Like BHLH Transcription Factor): FERD3L is a transcription factor with potential roles in neuronal development and differentiation. Its exact functions are still being elucidated, but it may be involved in neurodevelopmental processes....

FERD3L

FGF5 (Fibroblast Growth Factor 5): FGF5 is a member of the fibroblast growth factor family, a group of proteins known for their roles in cellular proliferation, differentiation, and signaling. As a key mediator of biological processes, FGF5 is involved in the regulation of hair growth cycles, and its activity has been linked to influencing hair length in various species. Beyond its role in hair follicle regulation, FGF5 contributes to the development and repair of tissues, including the nervous system, where it plays a role in neural development. Dysregulation of FGF5 has been implicated in certain pathological conditions, such as cancer,...

FGF5

SH3PXD2A (SH3 And PX Domains 2A, also known as TKS5): SH3PXD2A is a scaffold protein involved in the formation of podosomes or invadopodia in cells, structures associated with tissue remodeling, cell migration, and invasion. It plays a significant role in cancer metastasis and angiogenesis by facilitating the degradation of the extracellular matrix. SH3PXD2A's function in cellular dynamics and interaction with the environment makes it a potential target for cancer therapy, particularly in limiting cancer spread....



SH3PXD2A

FGFR2 (Fibroblast Growth Factor Receptor 2): FGFR2 is a receptor for fibroblast growth factors and is involved in numerous processes including cell growth, differentiation, and repair. Mutations in FGFR2 are associated with various developmental disorders, including craniosynostosis and skeletal dysplasia, and are implicated in certain types of cancer....

FGFR2

FFAR4 (Free Fatty Acid Receptor 4): FFAR4, also known as GPR120, is a receptor for omega-3 fatty acids and plays a significant role in metabolic regulation and inflammatory processes. It is involved in the regulation of insulin sensitivity, anti-inflammatory responses, and appetite control. Research suggests that FFAR4 is a potential therapeutic target for metabolic disorders like obesity and type 2 diabetes....

FFAR4

SGMS1 (Sphingomyelin Synthase 1): SGMS1 is involved in sphingolipid metabolism, which is crucial for cell membrane integrity and signaling. It plays a role in the conversion of ceramide to sphingomyelin, important in cell signaling and apoptosis. Dysregulation of SGMS1 has implications in metabolic and neurodegenerative diseases....



SGMS1

SH3YL1 (SH3 And SYLF Domain Containing 1): SH3YL1 is a gene that encodes a protein containing SH3 (Src homology 3) and SYLF domains, suggesting a role in protein-protein interactions. The specific function of SH3YL1 is still under investigation, but it may be involved in cellular signaling pathways and membrane dynamics....



SH3YL1

SH2B1 (SH2B Adaptor Protein 1): SH2B1 is a key adaptor protein that supports various intracellular signaling pathways, especially those related to insulin and leptin. It's important for energy balance, body weight regulation, and glucose metabolism. Genetic variants of SH2B1 are associated with obesity and insulin resistance....



SH2B1

FGGY (FGGY Carbohydrate Kinase Domain Containing): FGGY is a carbohydrate kinase involved in carbohydrate metabolism. Its exact role and functions are not fully elucidated, but carbohydrate kinases are known to be important in energy metabolism and may play roles in metabolic disorders....

FGGY

FGD4 (FYVE, RhoGEF, and PH Domain Containing 4): FGD4 encodes a guanine nucleotide exchange factor that specifically activates Cdc42, a member of the Rho family of GTPases. This activation plays a key role in regulating cytoskeletal organization, cell shape, and migration. Mutations in FGD4 are associated with Charcot-Marie-Tooth disease, a disorder affecting peripheral nerves, highlighting its importance in nerve development and function....

FGD4

SHC1 (SHC Adaptor Protein 1): SHC1 is an adaptor protein involved in the signal transduction pathways that regulate cell growth, differentiation, and survival. By mediating the activation of the Ras/MAPK signaling pathway, SHC1 influences cellular responses to growth factors and cytokines. Dysregulation of SHC1 has been implicated in the development of various cancers, as well as in cardiovascular diseases, highlighting its critical role in cellular signaling and disease pathogenesis....



SHC1

FGF10 (Fibroblast Growth Factor 10): FGF10 is critical in embryonic development, particularly in limb and lung development. It's involved in the proliferation and differentiation of cells in these tissues, and mutations can lead to developmental disorders like aplasia of the lung....

FGF10

SHISA4 (Shisa Family Member 4): SHISA4 is involved in the regulation of synaptic function and neuronal excitability. It modulates the activity of key receptors in the central nervous system, including AMPA and NMDA receptors, and is implicated in the regulation of neuronal signaling and plasticity. Its role in synaptic modulation makes it a gene of interest in the study of neurological disorders and synaptic dysfunctions....



SHISA4

FGF13 (Fibroblast Growth Factor 13): FGF13, a member of the fibroblast growth factor (FGF) family, operates at the crossroads of cellular growth and differentiation. This protein is a key orchestrator in the complex symphony of cellular processes, influencing cell development and differentiation. Its spotlight in the realm of neuroscience is well-established, where it contributes to the functioning of neurons. Researchers delve into the depths of FGF13's impact on neurological disorders, aiming to unlock its potential in understanding conditions that affect the brain and nervous system....

FGF13

SHLD1 (Shieldin Complex Subunit 1): SHLD1 is a component of the shieldin complex, which plays a key role in DNA repair. It is involved in the repair of double-strand breaks, particularly in non-homologous end joining, a crucial process for maintaining genomic stability and preventing mutagenesis....



SHLD1

SHMT1 (Serine Hydroxymethyltransferase 1): SHMT1 catalyzes the conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate, crucial for nucleotide synthesis and methylation reactions. Its function is vital for DNA replication and repair, impacting cell proliferation and genetic stability. SHMT1's role in folate metabolism links it to cancer risk and neurological disorders....



SHMT1

SHPRH (SNF2 Histone Linker PHD RING Helicase): SHPRH is a DNA helicase involved in the repair of DNA damage and the maintenance of genomic stability. It plays a critical role in the DNA damage response by facilitating the repair of DNA double-strand breaks, thereby preventing mutations that could lead to cancer. SHPRH has been identified as a tumor suppressor, with mutations in this gene associated with increased susceptibility to various cancers, highlighting its importance in protecting against genomic instability and tumorigenesis....



SHPRH

SHQ1 (SHQ1, H/ACA Ribonucleoprotein Assembly Factor): SHQ1 is a crucial assembly factor for H/ACA ribonucleoproteins (RNPs), which are involved in the processing and modification of RNA. This includes the maturation of rRNA, snRNA, and the stabilization of telomerase RNA component (TERC). SHQ1 plays a vital role in the biogenesis of H/ACA RNPs, essential for proper cell function and maintenance of genomic stability. Disruptions in SHQ1 function can lead to defects in RNA processing and are implicated in various cellular dysfunctions....



SHQ1

FHIT (Fragile Histidine Triad Diadenosine Triphosphatase): FHIT is a tumor suppressor gene involved in purine metabolism. Loss or alteration of this gene has been linked to a variety of cancers, indicating its role in tumor suppression....

FHIT

SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1): SORCS1 is a gene that encodes a receptor involved in protein trafficking and sorting. It plays a role in the regulation of receptor signaling and may have implications in neural development and synaptic function. ...



SORCS1

FHOD3 (Formin Homology 2 Domain Containing 3): FHOD3 is a member of the formin family of proteins, which play a crucial role in the organization and regulation of the actin cytoskeleton. This protein is particularly significant in cardiac muscle and other tissues, where it facilitates the assembly of actin filaments, thereby influencing cell shape, adhesion, and motility. FHOD3's activity is pivotal during cell division, migration, and muscle contraction, contributing to the proper functioning of cardiovascular and skeletal systems. Its regulatory mechanisms involve the dynamic remodeling of the actin cytoskeleton, essential for heart development and function. Dysregulation of FHOD3 has been...

FHOD3

SORCS2 (Sortilin-Related VPS10 Domain Containing Receptor 2): SORCS2 is involved in neuronal development and signaling. It is a member of the VPS10 domain-containing receptor family, which plays roles in neurotrophic signaling and neural plasticity. Dysregulation of SORCS2 has been linked to neurological disorders, including Alzheimer’s disease and schizophrenia....



SORCS2

FIBIN (Fibin): FIBIN is a gene that encodes a protein involved in embryonic development, particularly in the development of the heart and blood vessels. It plays a role in signaling pathways that regulate cell differentiation and tissue morphogenesis. Mutations in FIBIN are implicated in developmental disorders....

FIBIN

SIDT1 (SID1 Transmembrane Family, Member 1): SIDT1 is involved in the cellular uptake of double-stranded RNA, playing a role in RNA interference and antiviral responses. It is significant in understanding cellular mechanisms for fighting viral infections and in the study of RNA-based therapeutic strategies....



SIDT1

SORCS3 (Sortilin-Related VPS10 Domain Containing Receptor 3): SORCS3 is a member of the VPS10 domain-containing receptor family and plays a role in protein trafficking and sorting within cells. It is particularly important in the nervous system, where it regulates the trafficking of proteins involved in synaptic function. Dysregulation of SORCS3 has been linked to neurological disorders, including Alzheimer's disease and schizophrenia....



SORCS3

FYB2 (FYN Binding Protein 2): FYB2, also known as ADAP2, is involved in signal transduction pathways within immune cells. It acts as an adaptor protein, mediating interactions between various signaling molecules, and plays a role in the regulation of immune cell activation and response. Its function is important for understanding the mechanisms of immune regulation and potential immune-related disorders....

FYB2

SOS2 (Son of Sevenless Homolog 2): SOS2 is involved in cell signaling and the activation of the Ras/MAPK pathway. It serves as a crucial mediator in cellular responses to growth factors, cytokines, and extracellular signals, contributing to various physiological processes and cellular outcomes....



SOS2

FKBP4, also known as FK506-binding protein 4 or FKBP52, is a member of the FK506-binding protein (FKBP) family, which are peptidyl-prolyl cis-trans isomerases (PPIases) that function as molecular chaperones. FKBP4 is primarily found in the cytoplasm and nucleus of cells and is involved in regulating protein folding, trafficking, and signal transduction. One of the primary functions of FKBP4 is its role as a co-chaperone for steroid hormone receptors, including the glucocorticoid receptor (GR) and androgen receptor (AR). FKBP4 interacts with these receptors in the cytoplasm, facilitating their proper folding and assembly into functional complexes with heat shock proteins (HSPs). Upon ligand...

FKBP4

FZD1 (Frizzled Class Receptor 1): FZD1 is a member of the frizzled receptor family, pivotal components of the Wnt signaling pathway. This pathway plays a central role in developmental processes, tissue regeneration, and cancer progression. FZD1, as a Wnt receptor, serves as a key player in modulating cellular responses to Wnt ligands, thereby influencing critical biological events and holding potential implications in disease mechanisms....

FZD1

SIDT2 (SID1 Transmembrane Family Member 2): SIDT2 is involved in the cellular uptake of RNA molecules, playing a role in RNA interference (RNAi) mechanisms. It's important in the study of gene regulation and has potential implications in the development of RNA-based therapeutics. The function of SIDT2 in RNA transport is crucial for understanding how cells regulate gene expression and respond to external RNA molecules....



SIDT2

SOX2, short for SRY (Sex Determining Region Y)-Box 2, is a critical transcription factor that plays a pivotal role in embryonic development, stem cell pluripotency, and tissue homeostasis. Positioned predominantly within the nucleus of cells, SOX2 is involved in the regulation of gene expression by binding to specific DNA sequences and modulating the activity of target genes. One of the primary functions of SOX2 is its involvement in the maintenance of stem cell pluripotency and self-renewal. Alongside other transcription factors, such as OCT4 and NANOG, SOX2 forms a core regulatory network that sustains the undifferentiated state of embryonic stem cells and...

SOX2

FZD10 (Frizzled Class Receptor 10): FZD10 is a receptor for Wnt signaling proteins, playing an essential role in embryonic development, cell proliferation, and differentiation. This gene is particularly involved in the Wnt/β-catenin signaling pathway and has been implicated in cancer development, especially in the context of abnormal Wnt signaling....

FZD10

SOX4 (SRY-Box Transcription Factor 4): SOX4 is a transcription factor that plays a pivotal role in the regulation of embryonic development and cell fate determination. It is critical for the development of the heart, pancreas, and lymphocytes, as well as in the process of tumorigenesis. Overexpression of SOX4 has been implicated in the progression of several cancers, serving as a key regulator of cell proliferation, apoptosis, and metastasis, thus highlighting its dual role in development and cancer....



SOX4

FZD4 (Frizzled Class Receptor 4): FZD4 is a gene that encodes a receptor for Wnt signaling molecules. The Wnt signaling pathway is essential for embryonic development, tissue homeostasis, and stem cell regulation. FZD4's role in this pathway makes it a key player in processes like cell fate determination and tissue regeneration....

CRHR1

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