CXCR2 (C-X-C Motif Chemokine Receptor 2): CXCR2 is a receptor that binds C-X-C motif chemokines and plays a key role in directing leucocyte migration to sites of inflammation. It is especially important for recruiting neutrophils, which are vital for the body’s initial defence against infection or injury. Dysregulated CXCR2 signalling is linked to chronic inflammatory conditions such as COPD and asthma, and it also contributes to the tumour-promoting inflammatory environment in cancer. As a result, targeting CXCR2 signalling is a promising therapeutic approach for treating inflammatory diseases and limiting cancer progression.