DHEA-S, the sulfate form of DHEA, is more stable and abundant in blood. Blood measurement of DHEA-S provides a longer-term view of DHEA levels, useful for assessing hormonal balance, adrenal function, and aging-related changes over time....


Who would benefit from testing their DHEA-S levels?

Individuals with symptoms of adrenal insufficiency, those undergoing aging-related hormonal changes, or experiencing chronic fatigue and stress should consider DHEA-S blood testing.

What are symptoms of low or high DHEA-S levels?

High DHEA-S:

    • Increased oiliness of skin or acne
    • Hair thinning or excess facial/body hair in women
    • Irregular menstrual cycles in women
    • Increased aggression or irritability
    • Possible link to insulin resistance


    • Reduced muscle mass and strength
    • Weakened immune system
    • Dry skin or other aging skin changes
    • Decreased libido and sexual dysfunction
    • Fatigue and depression
    • Potential for bone density loss

What is the difference between DHEA and DHEA-S?

DHEA (Dehydroepiandrosterone) and DHEA-S (Dehydroepiandrosterone Sulfate) are both hormones produced by the adrenal glands, but they differ in their biological roles and stability. DHEA acts as a precursor to sex hormones like estrogen and testosterone. It is rapidly fluctuating and sensitive to the body’s immediate needs. In contrast, DHEA-S is a sulfate ester form of DHEA. It is more abundant and stable in the bloodstream, providing a longer-term indicator of adrenal function and overall health. DHEA-S is not directly involved in producing sex hormones but reflects the body’s DHEA reserve.

What is the difference between testsing DHEA in saliva and DHEA-S in blood?

Testing DHEA in saliva and DHEA-S in blood provides different insights due to the nature of these compounds and the mediums in which they are measured.

  • DHEA in Saliva: This test measures the free, bioavailable form of DHEA, reflecting the body’s immediate response to adrenal gland activity. It is more indicative of the current, active level of DHEA in the body, which can fluctuate significantly throughout the day or in response to stress.
  • DHEA-S in Blood: The blood test measures the level of DHEA-S, which is more stable and provides an overview of the long-term adrenal function. It’s a better indicator of the body’s overall reserve and capacity to produce DHEA over time rather than the immediate levels.

Test(s) that measure/test for DHEA-S

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