DSP

DSP (Desmoplakin) is a key protein that functions as a structural linker within cells, essential for the integrity and function of desmosomes—specialised cell-cell adhesion complexes found in epithelial and cardiac tissues. DSP plays a vital role in maintaining mechanical strength and cellular cohesion by anchoring intermediate filaments to desmosomal cadherins. This connection supports tissue stability in areas exposed to high mechanical stress, such as the skin, heart, and certain mucous membranes. Mutations in the DSP gene are associated with various genetic disorders, including cardiomyopathies and skin diseases, emphasising its importance in tissue architecture and function.