DSP

DSP (Desmoplakin): Desmoplakin is a key cytoskeletal linker protein essential for the structural integrity and function of desmosomes, which are specialized cell-cell adhesion structures in epithelial and cardiac tissues. It plays a critical role in the mechanical coupling and signal transduction that underlie cellular cohesion and stability. By anchoring intermediate filaments to desmosomal cadherins, DSP ensures the mechanical integrity of tissues subjected to significant stress, such as the skin, heart, and certain mucosal surfaces. Mutations in the DSP gene can lead to a variety of genetic disorders, including cardiomyopathies and skin diseases, highlighting its crucial role in tissue architecture and...