EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a gene that encodes a key component of the eIF4F complex, which is involved in the initiation of protein synthesis. It plays a crucial role in recruiting ribosomes to mRNA, enabling efficient translation and protein production. Proper functioning of EIF4G3 is essential for cell growth and differentiation, while its dysregulation may contribute to diseases such as cancer, where protein synthesis is often disrupted.