EPM2A is a gene that encodes laforin, a phosphatase enzyme involved in glycogen metabolism. Laforin plays a crucial role in preventing the accumulation of abnormal glycogen deposits known as Lafora bodies, which are toxic to neurons. Mutations in EPM2A cause Lafora disease, a rare and fatal form of progressive myoclonic epilepsy. This underscores the critical role of EPM2A in maintaining neuronal health through metabolic regulation.