FLNB (Filamin B): FLNB encodes a protein that is crucial for the cross-linking of actin filaments in the cytoskeleton. Mutations in FLNB cause a range of skeletal disorders known as filaminopathies, which include conditions like spondylocarpotarsal synostosis syndrome and Larsen syndrome. These disorders are characterized by skeletal malformations and joint dislocations.


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