Globulin is a group of proteins in the blood that play various roles, including transporting hormones, lipids, vitamins, and minerals. They are also crucial components of the immune system, with certain globulins acting as antibodies that help fight infections. Globulins are synthesized in the liver and immune system, and their levels can indicate the status of immune response, liver function, and nutritional health.


Who would benefit from testing their globulin value?

  • Individuals with symptoms suggesting immune system disorders or infections.
  • Patients with liver diseases, as some globulins are produced in the liver.
  • Those with suspected nutritional deficiencies or malabsorption issues.
  • Patients being evaluated for conditions like multiple myeloma or other blood disorders.

What are the common symptoms of too high / low globulin values?

  • Common symptoms of high globulin values:
    • Symptoms related to the underlying cause, such as liver disease (jaundice, abdominal swelling) or autoimmune disorders (joint pain, skin rashes).
    • In case of multiple myeloma or similar conditions: bone pain, frequent infections, and fatigue.

    Common symptoms of low globulin values:

    • Increased susceptibility to infections.
    • Edema (swelling, particularly in the ankles and feet).
    • Muscle weakness.

What can cause too high / low globulin values in blood?

High globulin levels can be caused by:

  • Chronic infections or inflammatory diseases.
  • Liver diseases like hepatitis or cirrhosis.
  • Blood disorders such as multiple myeloma.

Low globulin levels can be caused by:

  • Acute liver disease.
  • Kidney diseases that cause protein loss.
  • Severe malnutrition or malabsorption disorders.

What can I do to improve globulin?

  • Address underlying medical conditions like liver or kidney disease, infections, or autoimmune disorders.
  • Ensure adequate nutrition, focusing on a balanced diet with sufficient protein intake.
  • Regular medical check-ups to monitor and manage any ongoing health issues.
  • Specific treatments will depend on the underlying cause of abnormal globulin levels, so it’s important to follow the advice of healthcare professionals.

Test(s) that measure/test for Globulin

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