HERC2 (HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 2): HERC2 is an E3 ubiquitin-protein ligase that plays a crucial role in the ubiquitin–proteasome system, which governs protein degradation. It is involved in various cellular processes, including DNA repair and pigment production, particularly influencing eye colour. Variations in HERC2 are associated with neurodevelopmental disorders and pigmentary abnormalities.