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Holotranscobalamin (B12)
Holotranscobalamin (holoTC), also known as active vitamin B12, is the form of vitamin B12 bound to transcobalamin, a transport protein in the blood. It is the only form that can be absorbed by cells through receptor-mediated endocytosis, making it directly available for cellular functions. Measuring holoTC provides a more accurate indication of recent vitamin B12 status than total vitamin B12, as it represents the fraction that is immediately available for use by the body.
Description
Who would benefit from testing their holotranscobalamin levels?
Individuals who are at risk of vitamin B12 deficiency, such as vegetarians, elderly people, and those with absorption impairments like pernicious anemia or gastrointestinal disorders, would benefit from testing their holotranscobalamin levels. It helps in early detection and management of deficiency.
What are symptoms of low holotranscobalamin?
Symptoms of low holotranscobalamin, indicating vitamin B12 deficiency, include fatigue, weakness, memory loss, neurological and psychiatric problems, and anemia. These symptoms result from the impaired production of DNA and red blood cells and neurological function.
How does holotranscobalamin differ from total vitamin B12 testing?
Holotranscobalamin testing measures only the biologically active portion of vitamin B12 available for cellular uptake, providing a more accurate reflection of functional vitamin B12 status. In contrast, total vitamin B12 testing measures all forms of B12, including those that are not immediately available to cells, which can sometimes mask deficiencies.
What causes low holotranscobalamin levels?
Low holotranscobalamin levels are primarily caused by dietary inadequacy, malabsorption syndromes, pernicious anemia, certain medications, and age-related decline in absorption. These factors lead to insufficient availability of biologically active vitamin B12.
Tests containing this item
Lab TestPersistent fatigue and thyroid issues are often linked to B12 levels. While a standard B12 test might show normal total levels, it is the active form of B12, which makes up only 10-30% of the total, that plays a vital role in your health. GetTested’s Vitamin B12 Test specifically measures this active form. For a more comprehensive health assessment, our Vitamin Test includes standard B12, folate, vitamins D and E, and CoQ10, providing a detailed nutrient profile for those looking to address fatigue.
59.99 GBP
