Homocysteine

Homocysteine is a sulphur-containing amino acid produced during the metabolism of methionine, an essential amino acid. It plays a key role in methylation, detoxification, and cardiovascular function. Elevated homocysteine levels have been associated with increased risk of heart disease, stroke, cognitive decline, and pregnancy complications. Imbalances may be caused by deficiencies in B vitamins (especially B6, B12, and folate), impaired methylation, or genetic variants like MTHFR. Monitoring homocysteine levels can provide valuable insights into cardiovascular, neurological, and metabolic health.

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What does an elevated homocysteine level signify?

Elevated homocysteine is often associated with a higher risk of cardiovascular disease, impaired detoxification, inflammation, and neurological issues such as memory problems or mood disturbances.

What causes homocysteine levels to increase?

Common causes include deficiencies in vitamin B6, B12, or folate, genetic polymorphisms (e.g., MTHFR), poor methylation, chronic stress, and impaired kidney function.

Are there symptoms of elevated homocysteine?

High homocysteine often has no symptoms, but may be associated with fatigue, brain fog, irritability, or numbness and tingling if left unaddressed.

How can homocysteine levels be lowered?

Improving B-vitamin status—particularly folate, B6, and B12—through diet or supplementation can help normalise homocysteine. Addressing methylation imbalances may also be necessary.

Why is it important to monitor homocysteine?

Because it reflects both cardiovascular and methylation health, monitoring homocysteine can help identify silent imbalances that may contribute to chronic disease if left untreated.

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Content
What does an elevated homocysteine level signify?
What causes homocysteine levels to increase?
Are there symptoms of elevated homocysteine?
How can homocysteine levels be lowered?
Why is it important to monitor homocysteine?
What does an elevated homocysteine level signify?
What causes homocysteine levels to increase?
Are there symptoms of elevated homocysteine?
How can homocysteine levels be lowered?
Why is it important to monitor homocysteine?
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