Homocysteine
Homocysteine is a sulphur-containing amino acid produced during the metabolism of methionine, an essential amino acid. It plays a key role in methylation, detoxification, and cardiovascular function. Elevated homocysteine levels have been associated with increased risk of heart disease, stroke, cognitive decline, and pregnancy complications. Imbalances may be caused by deficiencies in B vitamins (especially B6, B12, and folate), impaired methylation, or genetic variants like MTHFR. Monitoring homocysteine levels can provide valuable insights into cardiovascular, neurological, and metabolic health.
Description
Elevated homocysteine is often associated with a higher risk of cardiovascular disease, impaired detoxification, inflammation, and neurological issues such as memory problems or mood disturbances.
Common causes include deficiencies in vitamin B6, B12, or folate, genetic polymorphisms (e.g., MTHFR), poor methylation, chronic stress, and impaired kidney function.
High homocysteine often has no symptoms, but may be associated with fatigue, brain fog, irritability, or numbness and tingling if left unaddressed.
Improving B-vitamin status—particularly folate, B6, and B12—through diet or supplementation can help normalise homocysteine. Addressing methylation imbalances may also be necessary.
Because it reflects both cardiovascular and methylation health, monitoring homocysteine can help identify silent imbalances that may contribute to chronic disease if left untreated.
