KISS1R

KISS1R (Kisspeptin Receptor): KISS1R, also known as GPR54, is a receptor crucial for the activation of the hypothalamic-pituitary-gonadal axis, playing a pivotal role in the onset of puberty and fertility. It binds to kisspeptin, a neuropeptide that stimulates the release of gonadotropin-releasing hormone, thereby influencing reproductive hormone levels. Mutations in KISS1R can lead to hypogonadotropic hypogonadism, a condition characterized by delayed or absent puberty and reproductive dysfunction. The receptor is also implicated in the regulation of metabolic processes and has been studied in the context of tumor suppression....