LIN28B

LIN28B is a highly conserved RNA-binding protein that plays diverse and crucial roles in regulating various cellular processes, including stem cell maintenance, development, metabolism, and oncogenesis. It belongs to the LIN28 family, which also includes LIN28A. One of the primary functions of LIN28B is its involvement in post-transcriptional regulation of gene expression through binding to specific mRNA targets. LIN28B primarily acts as a translational repressor, inhibiting the translation of its target mRNAs by blocking the recruitment of ribosomes. Additionally, LIN28B can also influence mRNA stability and processing through interactions with RNA-binding proteins and microRNAs (miRNAs). Moreover, LIN28B is a key regulator of...