LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma) is a protein involved in regulating cell adhesion, migration, and the organisation of the actin cytoskeleton. It plays a key role in forming focal adhesions and stress fibres, which connect the cytoskeleton to the extracellular matrix. LPP’s function is essential for controlling cell movement and maintaining cellular structure. Changes in LPP have been linked to the development of lipomas and other tumours, underscoring its significance in cell biology and cancer research.