MACF1 (Microtubule-Actin Crosslinking Factor 1): MACF1 is a gene that encodes a cytoskeletal linker protein involved in stabilising and connecting microtubules and actin filaments. It plays an important role in cell motility, neuronal development, and cellular signalling. Dysfunction in MACF1 is associated with developmental disorders and may contribute to cancer metastasis.