MCFD2 (Multiple Coagulation Factor Deficiency 2): MCFD2 is a gene that encodes a protein vital for the transport and correct folding of coagulation factors V and VIII, which are essential for blood clotting. Mutations in MCFD2 can cause combined factor V and VIII deficiency, a rare bleeding disorder, emphasising its crucial role in haemostasis and the effect of impaired protein transport on blood clotting.