MME, also known as Membrane Metallo-Endopeptidase or neprilysin, is a zinc-dependent metalloprotease enzyme that plays a key role in regulating peptide signalling molecules. It is primarily found on the cell membrane of various cell types, including neurons, endothelial cells, and immune cells. MME is particularly important for breaking down peptides involved in blood pressure regulation, such as bradykinin and atrial natriuretic peptide (ANP), converting them into inactive fragments and helping to maintain cardiovascular homeostasis.