MTR

MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase) plays a crucial role in homocysteine metabolism by catalyzing the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, producing methionine and tetrahydrofolate. This process is essential for maintaining normal homocysteine levels and supporting vital methylation reactions in the body, such as DNA methylation and neurotransmitter synthesis. Dysregulation of MTR, often due to genetic mutations or vitamin B12 deficiencies, can lead to hyperhomocysteinemia, associated with increased risks of cardiovascular and neurodegenerative diseases, and pregnancy complications. Management may include supplementation with vitamin B12 and folate and research continues into new therapeutic strategies to address these disorders....