NFATC2 (Nuclear Factor Of Activated T-Cells 2): NFATC2 is a transcription factor that plays a crucial role in regulating immune responses. It is activated in T cells by signals that increase intracellular calcium, enabling it to translocate to the nucleus and influence genes involved in T cell activation and differentiation. NFATC2 is essential for proper immune system development, and its dysregulation has been associated with autoimmune diseases and immunodeficiency.