NRBF2 (Nuclear Receptor Binding Factor 2): NRBF2 is a protein involved in autophagy, a cellular process that degrades and recycles damaged or unnecessary components. NRBF2 plays a key role in regulating autophagy by helping to form autophagosomes, the double-membraned vesicles that capture cellular cargo for degradation. It interacts with the ULK1 kinase complex – which includes ULK1, ATG13, FIP200, and ATG101 – promoting its stability and activity, which is essential for initiating autophagy.