ORMDL3 (ORMDL Sphingolipid Biosynthesis Regulator 3): ORMDL3 is a gene that regulates the production of sphingolipids, essential components of cell membranes and signalling pathways. It helps maintain lipid balance in cells and influences inflammatory responses. Variations in ORMDL3 have been linked to a higher risk of asthma and allergic diseases, emphasising its role in immune regulation and inflammation.