PAX2
PAX2 (Paired Box Gene 2): PAX2 is a key transcription factor in the paired box gene family that plays a vital role in the development of the kidneys and urinary tract. It acts early in embryonic stages to regulate tissue and organ formation, directing the development of the renal system, eye, ear, and central nervous system. By controlling cell proliferation, differentiation, and apoptosis, PAX2 contributes to the formation of essential structures within these systems. Abnormalities in PAX2 expression or function have been linked to congenital anomalies of the kidney and urinary tract (CAKUT), as well as other developmental disorders.
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