PFKFB3

PFKFB3, or 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, is an enzyme that plays a crucial role in cellular energy metabolism, particularly in glycolysis, the process by which glucose is metabolized to produce energy. PFKFB3 regulates the levels of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric regulator of 6-phosphofructo-1-kinase (PFK-1), a key enzyme in glycolysis. One of the primary functions of PFKFB3 is its role in promoting glycolysis by synthesizing F2,6BP. F2,6BP allosterically activates PFK-1, which catalyzes the conversion of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP), a critical regulatory step in glycolysis. By increasing F2,6BP levels, PFKFB3 stimulates PFK-1 activity, enhancing the flux of glucose through the glycolytic pathway...