PKD2L1 (Polycystic Kidney Disease 2-Like 1): PKD2L1 is a transmembrane protein belonging to the polycystic kidney disease family, primarily located in sensory neurons of the peripheral nervous system and certain epithelial cells. It plays a crucial role in chemosensation and mechanosensation, particularly in detecting sour taste. Functioning as a non-selective cation channel, PKD2L1 facilitates ion influx in response to extracellular stimuli, initiating cellular responses. It is also involved in processes such as gastrointestinal sensory signalling and blood pressure regulation.