PPIF (Peptidylprolyl Isomerase F): PPIF, also known as cyclophilin D, is a key mitochondrial enzyme that regulates the mitochondrial permeability transition pore (MPTP). This pore plays a vital role in controlling cell death processes such as apoptosis and necrosis. PPIF’s activity is crucial in these pathways, and its inhibition has been investigated as a potential therapeutic strategy for conditions including ischaemia-reperfusion injury, such as heart attack and stroke.