PRDM5 (PR Domain Containing 5): PRDM5 is a transcription factor that plays a crucial role in regulating gene expression, cellular differentiation, and the organisation of the extracellular matrix. It is essential for the development and maintenance of tissues such as bone, cartilage, and connective tissue. Mutations in PRDM5 are linked to brittle cornea syndrome and other connective tissue disorders, emphasising its importance in tissue integrity and health.