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GetTested’s DNA Skin & Beauty test analyses genes that influence your skin’s health and provides you with personalized recommendations based on your genetics. The test covers a range of factors from skin aging to specific skin conditions like age spots and sensitivity, to your predisposition to various skin problems such as acne and rosacea.

GetTested’s DNA Skin & Beauty test analyses genes that influence your skin’s health and provides you with personalized recommendations based on your genetics. The test covers a range of factors from skin aging to specific skin conditions like age spots and sensitivity, to your predisposition to various skin problems such as acne and rosacea.

DNA Skin & Beauty Test

Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

DNA Fatigue Test

DNA Diet & Nutrition from GetTested is a health test that analyses your genetic variations to provide a detailed understanding of how your body processes various nutrients. Utilizing a simple saliva sample for DNA collection, this test delivers insights into your genetic makeup related to diet and nutrition. It offers a personalized analysis of macronutrients, fat metabolism, vitamin and mineral requirements, as well as genetic predispositions to various sensitivities/intolerances and eating behaviors.

DNA Diet & Nutrition from GetTested is a health test that analyses your genetic variations to provide a detailed understanding of how your body processes various nutrients. Utilizing a simple saliva sample for DNA collection, this test delivers insights into your genetic makeup related to diet and nutrition. It offers a personalized analysis of macronutrients, fat metabolism, vitamin and mineral requirements, as well as genetic predispositions to various sensitivities/intolerances and eating behaviors.

DNA Diet & Nutrition Test

UBQLN2, also known as Ubiquilin-2, is a protein involved in the ubiquitin-proteasome system (UPS), a crucial pathway for protein degradation within cells. It belongs to the ubiquilin family of proteins, which are characterized by containing ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains that facilitate interactions with ubiquitinated proteins and proteasome components. One of the primary functions of UBQLN2 is its role in protein quality control and degradation. UBQLN2 acts as a shuttle factor, facilitating the delivery of ubiquitinated proteins to the proteasome for degradation. It binds to ubiquitinated proteins through its UBA domain and interacts with components of the proteasome, promoting the...




UBQLN2

UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5): UBR5 is a gene that encodes an E3 ubiquitin ligase, which is involved in protein degradation via the ubiquitin-proteasome pathway. UBR5 plays a role in the regulation of protein stability and turnover. Dysfunctions in UBR5 can impact various cellular processes and have implications in cancer development and neurodegenerative diseases. Understanding UBR5 is significant for research into protein homeostasis and cellular quality control....




UBR5

GOLGA8B (Golgin A8 Family Member B): GOLGA8B is a member of the golgin family of proteins, involved in the structure and function of the Golgi apparatus. It plays a role in vesicle trafficking and cellular organization, although its specific functions are not fully understood....

GOLGA8B

UBXN2A (UBX Domain Protein 2A): UBXN2A is involved in the ubiquitin-proteasome system, which regulates protein degradation and quality control in cells. It may play a role in the response to cellular stress and in the regulation of protein turnover, which is vital for maintaining cellular health and preventing diseases....




UBXN2A

GP2 (Glycoprotein 2): GP2 is a membrane-bound protein primarily found in the pancreas and is involved in immune responses in the gastrointestinal tract. It is important for the binding and aggregation of bacteria, playing a role in protecting the gut from microbial invasion. Alterations in GP2 are studied in the context of pancreatic disorders and inflammatory bowel diseases....

ZNF816 (Zinc Finger Protein 816): ZNF816 belongs to the family of zinc finger proteins, which are involved in DNA binding and gene transcription regulation. Although specific functions of ZNF816 are less characterized, zinc finger proteins play crucial roles in developmental processes, cellular differentiation, and the regulation of gene expression. Research on ZNF816 and similar proteins aims to uncover their contributions to cellular processes and their potential links to diseases, including cancer and genetic disorders....

ZNF816

GPD2 (Glycerol-3-Phosphate Dehydrogenase 2): GPD2 is an enzyme involved in glycerol metabolism and lipid biosynthesis. It catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, a critical step in lipid synthesis. GPD2's function is important for energy storage and lipid homeostasis....

GPD2

UCN3, also known as Urocortin 3, is a peptide hormone belonging to the corticotropin-releasing factor (CRF) family. It is primarily expressed in the central nervous system, particularly in regions of the brain involved in stress response regulation, such as the hypothalamus, amygdala, and brainstem. One of the primary functions of UCN3 is its role in modulating the stress response and anxiety-related behaviors. Like other members of the CRF family, UCN3 acts as a neuromodulator, influencing the activity of neurons and circuits involved in the physiological and behavioral responses to stress. UCN3 binds to and activates specific receptors, including CRF receptor type...




UCN3

ZSCAN31 (Zinc Finger And SCAN Domain Containing 31): ZSCAN31 is a member of the zinc finger protein family, which is involved in DNA binding and gene transcription regulation. While specific functions of ZSCAN31 are still being elucidated, zinc finger proteins play significant roles in developmental processes, cellular differentiation, and the regulation of gene expression. Research on ZSCAN31 focuses on understanding its contribution to genetic regulation and its potential link to diseases, including its role in chromosomal stability and cancer....




ZSCAN31

GPM6A (Glycoprotein M6A): GPM6A encodes a glycoprotein primarily expressed in the nervous system, playing a critical role in neurite outgrowth and the formation of neuronal networks. It's involved in the development and maintenance of the myelin sheath, crucial for efficient nerve signal transmission. GPM6A has been implicated in neurological disorders, including schizophrenia and bipolar disorder, due to its role in neuronal plasticity and myelination. Research suggests that alterations in GPM6A expression or function can impact synaptic connectivity and brain function, potentially contributing to the pathophysiology of these neuropsychiatric conditions....

GPM6A

BLMH (Bleomycin Hydrolase): BLMH is an enzyme crucial for metabolizing and detoxifying the chemotherapeutic drug bleomycin. Bleomycin is effective in treating cancer by causing DNA damage in cancer cells, but it can also lead to lung toxicity as a side effect. BLMH plays a pivotal role in breaking down bleomycin into harmless compounds, reducing the risk of lung toxicity. Understanding BLMH's function is vital for optimizing cancer treatment and managing its side effects, particularly in patients receiving bleomycin-based therapies. Researchers are actively exploring strategies to enhance the safety and effectiveness of cancer treatments involving bleomycin....



BLMH

GPR139, also known as G protein-coupled receptor 139, is a protein that belongs to the G protein-coupled receptor (GPCR) superfamily. It is primarily expressed in the central nervous system, particularly in regions associated with the regulation of neurotransmitter systems and neuronal activity. Although the specific functions of GPR139 are still being elucidated, it is believed to play a role in modulating neurotransmission, particularly in the regulation of dopamine and glutamate signaling. Studies have suggested that GPR139 may function as an inhibitory receptor, as its activation leads to decreased cAMP (cyclic adenosine monophosphate) levels and reduced neuronal excitability. Moreover, GPR139 has been implicated...

GPR139

BLOC1S2 (Biogenesis of Lysosomal Organelles Complex-1, Subunit 2): BLOC1S2 is part of a protein complex involved in the biogenesis of lysosome-related organelles, such as melanosomes and platelet dense granules. Dysfunctions in BLOC1S2 can affect organelle formation and function, potentially leading to disorders related to pigmentation or blood clotting....



BLOC1S2

UCP3 (Uncoupling Protein 3): UCP3 is a member of the mitochondrial uncoupling proteins, playing a role in thermogenesis and energy balance. It is implicated in the regulation of body weight and metabolism, and its activity can influence obesity and metabolic disorders....




UCP3

BMP2 (Bone Morphogenetic Protein 2): BMP2 is a member of the TGF-beta superfamily, known for its critical roles in bone and cartilage development. It induces bone formation and regeneration, making it a key factor in skeletal homeostasis. Dysregulation of BMP2 signaling has been associated with various skeletal disorders and has implications in cardiovascular disease, underscoring its potential in regenerative medicine and tissue engineering....



BMP2

UGT1A6 (UDP Glucuronosyltransferase Family 1 Member A6): UGT1A6 is a gene that encodes an enzyme from the UDP glucuronosyltransferase family. These enzymes play a vital role in phase II metabolism, where they facilitate the conjugation of drugs, toxins, and endogenous substances with glucuronic acid, aiding in their elimination from the body. UGT1A6's function is essential for detoxification processes and maintaining overall metabolic balance....

UGT1A6

GPR151 (G Protein-Coupled Receptor 151): GPR151 is a gene that encodes a G protein-coupled receptor (GPCR). GPCRs are involved in cell signaling and can respond to various signaling molecules. The specific function of GPR151 is still being investigated, but it may play a role in neural and metabolic processes....

GPR151

ULK3 (Unc-51 Like Kinase 3): ULK3 is part of the serine/threonine kinase family, involved in various cellular processes including autophagy, a mechanism for degrading and recycling cellular components. Its specific roles and implications in human health and disease are still being explored....




ULK3

BMP6 (Bone Morphogenetic Protein 6): BMP6 is part of the bone morphogenetic protein family, which is crucial in the development and repair of bone and cartilage. It is involved in various cellular processes including cell growth, apoptosis, and differentiation. BMP6 has been studied in the context of osteogenesis and is also implicated in cancer progression....



BMP6

UNC119B (UNC-119 Homolog B): UNC119B is involved in the trafficking of proteins to cilia, cellular structures important in signaling pathways and sensory functions. It plays a role in the development and function of photoreceptor cells in the retina. Dysfunctions in UNC119B can impact ciliary function, potentially leading to retinal diseases and impairing vision....

UNC119B

UNCX (Unc-4 Homeobox): UNCX encodes a homeobox-containing transcription factor involved in neuronal development and axon guidance. It plays a role in specifying neuronal identity and connectivity in the developing nervous system....




UNCX

UPB1 (Beta-Ureidopropionase 1): UPB1 is an enzyme involved in the catabolism of pyrimidines. Deficiencies in UPB1 can lead to beta-ureidopropionase deficiency, a rare disorder affecting the breakdown of nucleotides, leading to neurological symptoms and developmental delay....

UPB1

UPP1 (Uridine Phosphorylase 1): UPP1 is involved in the pyrimidine salvage pathway, converting uridine to uracil and ribose-1-phosphate. It plays a key role in nucleotide metabolism, impacting various cellular processes including DNA and RNA synthesis. Its function is particularly relevant in chemotherapy, as it affects the activation and effectiveness of certain anticancer drugs....

UPP1

GPR158 (G Protein-Coupled Receptor 158): GPR158 is a member of the G protein-coupled receptor family and is involved in various physiological processes, including neuronal development and regulation of mood and behavior. It has been implicated in conditions such as depression and anxiety, highlighting its role in mental health....

GPR158

BNIP5 (BCL2/Adenovirus E1B 19 kDa Interacting Protein 5): BNIP5 is involved in apoptosis and cell survival pathways. It interacts with members of the Bcl-2 family, proteins known for their roles in regulating cell death and survival, making it significant in studies of cancer and cellular stress responses....



BNIP5

GPR25 (G Protein-Coupled Receptor 25): GPR25 is part of the G protein-coupled receptor family and is implicated in various physiological processes, including signal transduction and cell communication. Its specific functions and roles in human health and disease are still under investigation....

GPR25

BORCS7 (BLOC-1 Related Complex Subunit 7): BORCS7 is a component of the BLOC-1 (Biogenesis of Lysosome-related Organelles Complex-1). It's involved in the biogenesis of lysosome-related organelles, such as melanosomes in melanocytes. Dysfunctions in BORCS7 may impact pigmentation and neurological functions....



BORCS7

GPR26 (G Protein-Coupled Receptor 26): GPR26 is an orphan receptor whose specific ligand and physiological role are not well-characterized. However, it is thought to be involved in central nervous system function, potentially playing a role in regulating mood and behavior. Studies suggest that GPR26 may have implications for neurological conditions and psychiatric disorders, making it a target of interest for drug discovery and neuroscience research....

GPR26

GPR83 (G Protein-Coupled Receptor 83): GPR83 is a G protein-coupled receptor (GPCR) that is expressed in the brain and is involved in the regulation of appetite and energy homeostasis. It has been studied in the context of feeding behavior and metabolic disorders....

GPR83

URAD (Ureidoimidazole-4-Carboxamide Ribonucleotide Decarboxylase): URAD is involved in the de novo synthesis of purine nucleotides, which are essential for DNA and RNA production. It plays a role in nucleotide metabolism and is critical for cell proliferation and growth....

URAD

BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase): BRAF is a key player in the MAPK/ERK signaling pathway, which regulates cell growth, proliferation, and differentiation. Mutations in BRAF are implicated in various cancers, including melanoma, thyroid cancer, and colorectal cancer. BRAF mutations are also involved in certain non-cancerous conditions, such as cardiofaciocutaneous syndrome, which affects the heart, facial features, and skin....



BRAF

USP25 (Ubiquitin Specific Peptidase 25): USP25 encodes an enzyme that is part of the ubiquitin-proteasome pathway, responsible for removing ubiquitin from proteins, thereby regulating their degradation. It is involved in various cellular processes, including signal transduction and stress response. Alterations in USP25 are linked to immune system dysregulation and potentially to cancer....




USP25

USP47 (Ubiquitin Specific Peptidase 47): USP47 is an enzyme that specifically removes ubiquitin from ubiquitinated proteins, thereby regulating their degradation. It plays a crucial role in DNA repair, cell cycle regulation, and signal transduction by maintaining protein stability. Dysregulation of USP47 has been implicated in the development of various cancers and other diseases, where it affects processes such as cell proliferation and apoptosis. Understanding USP47's function is essential for exploring new therapeutic strategies for cancer and other diseases associated with protein degradation pathways....

USP47

UST (Uronyl 2-Sulfotransferase): UST is an enzyme involved in the sulfation of proteoglycans, which are important components of the extracellular matrix. It plays a role in various biological processes, including cell signaling and tissue repair. Dysregulation of UST activity can impact connective tissue function and may be relevant in disorders involving the extracellular matrix....

GPSM1 (G Protein Signaling Modulator 1): GPSM1 is involved in modulating G protein signaling, crucial for various cellular responses to external stimuli. It plays a role in cell polarization and directional movement, and has been studied in the context of cancer, particularly in relation to its potential role in tumor cell migration and invasion....

GPSM1

UTP20 (UTP20, Small Subunit Processome Component): UTP20 is involved in the processing and assembly of the 18S rRNA, a crucial component of the small ribosomal subunit. It plays a role in ribosome biogenesis, which is essential for protein synthesis. Dysfunctions in UTP20 can affect cell growth and proliferation, with potential implications in developmental disorders and cancers....




UTP20

BRINP1, or BMP/retinoic acid-inducible neural-specific protein 1, is a member of the BRINP (BMP/retinoic acid-inducible neural-specific) family of proteins. It is predominantly expressed in the brain and has been implicated in various neuronal processes, including neurodevelopment, synaptic plasticity, and neuronal survival. One of the primary functions of BRINP1 is its involvement in neural development. It is induced by factors such as bone morphogenetic proteins (BMPs) and retinoic acid during early neural development, suggesting a role in patterning and differentiation of neural progenitor cells. BRINP1 expression is spatially and temporally regulated in the developing brain, suggesting its involvement in processes such as...



BRINP1

VAV2 (Vav Guanine Nucleotide Exchange Factor 2): VAV2 is a guanine nucleotide exchange factor (GEF) that is primarily involved in transducing signals from tyrosine kinase receptors to Rho GTPases, affecting cell morphology, motility, and proliferation. It plays a significant role in various cellular processes, including cytoskeletal dynamics and cell signaling pathways. Dysregulation of VAV2 has been linked to cancer progression, making it a subject of interest for understanding tumorigenesis and metastasis....




VAV2

VAV3 (Vav Guanine Nucleotide Exchange Factor 3): VAV3 encodes a guanine nucleotide exchange factor that is involved in intracellular signaling pathways related to cell proliferation and cytoskeletal rearrangement. It plays a role in immune cell activation and may have implications in immune responses and cancer....




VAV3

BRK1 (Breakpoint cluster region kinase 1): Similar to MMP15's pivotal role in extracellular matrix (ECM) remodeling, BRK1 is a crucial player in cellular signaling pathways that regulate cell proliferation, differentiation, and migration. As a member of the breakpoint cluster region kinase family, BRK1 modulates intracellular signaling cascades, influencing various physiological processes such as cell cycle progression, cytoskeletal organization, and cell adhesion. Additionally, BRK1 has been implicated in the regulation of immune responses and oncogenic signaling pathways, highlighting its significance in both normal physiological functions and disease pathogenesis. Dysregulation of BRK1 expression or activity has been associated with cancer progression, inflammatory...



BRK1

VCAN (Versican): VCAN is a gene that codes for versican, a large proteoglycan found in the extracellular matrix of tissues. Versican is involved in cell adhesion, migration, and tissue development. It plays a role in maintaining tissue structure and may contribute to processes like wound healing and embryonic development....

VCAN

GRAMD2B (GRAM Domain Containing 2B): GRAMD2B is part of the GRAM domain family, involved in cellular processes like lipid binding and transport. Its specific functions in human physiology are not fully understood, but such domains are often associated with membrane-related processes....

GRAMD2B

VEGFA (Vascular Endothelial Growth Factor A): Much like MMP15's involvement in tissue remodeling and angiogenesis, VEGFA holds a central role in regulating blood vessel formation and vascular function. As a key member of the vascular endothelial growth factor (VEGF) family, VEGFA stimulates the proliferation and migration of endothelial cells, promoting the formation of new blood vessels (angiogenesis) crucial for various physiological processes including wound healing, embryonic development, and tissue repair. The precise regulation of VEGFA expression and activity is essential for maintaining vascular integrity and homeostasis. Dysregulation of VEGFA signaling has been implicated in numerous pathological conditions, including cancer progression,...

VEGFA

BRSK2 (BR Serine/Threonine Kinase 2): BRSK2 is a member of the AMP-activated protein kinase family and is involved in neuronal development and polarization. It plays a role in synaptic plasticity and neuron maturation. Mutations or alterations in BRSK2 have implications in neurological disorders and could contribute to the development of neurodevelopmental diseases....



BRSK2

VIPR1 (Vasoactive Intestinal Peptide Receptor 1): VIPR1 encodes a receptor for vasoactive intestinal peptide, a neuropeptide involved in a wide range of physiological processes, including smooth muscle relaxation, immune regulation, and water and ion flux in the lungs. It plays a significant role in circadian rhythms and is implicated in various disorders, including asthma and pulmonary hypertension....

VIPR1

VIPR2 (Vasoactive Intestinal Peptide Receptor 2): VIPR2 encodes a receptor for vasoactive intestinal peptide (VIP), a neuropeptide involved in various physiological processes, including smooth muscle relaxation, immune modulation, and neurotransmission. VIPR2 is found on the surface of cells in various tissues and plays a role in VIP signaling....

VIPR2

BSN (Bassoon Presynaptic Cytomatrix Protein): BSN is crucial for the proper assembly of active zones at synaptic terminals, facilitating neurotransmitter release. This protein's role in the structural organization of synapses is vital for synaptic transmission and plasticity, impacting learning and memory. Alterations in BSN function or expression can influence neurological function and have been associated with various neuropsychiatric disorders....



VLDLR (Very Low Density Lipoprotein Receptor): VLDLR is a component of the lipid metabolism pathway, facilitating the uptake of triglyceride-rich lipoproteins into cells for energy utilization or storage. It plays a critical role in neuronal migration and cerebellar development. Mutations in VLDLR are associated with a rare genetic disorder known as dysequilibrium syndrome, characterized by cerebellar hypoplasia and cognitive disability, emphasizing its role in lipid metabolism and brain development....

VLDLR

GRIA1: GRIA1, or Glutamate Ionotropic Receptor AMPA Type Subunit 1, is a gene that encodes a key subunit of AMPA receptors, which are crucial for fast synaptic transmission in the brain. These receptors are responsive to the neurotransmitter glutamate, which is the most abundant excitatory neurotransmitter in the vertebrate nervous system. The GRIA1 subunit is integral in mediating synaptic plasticity, a foundation for learning and memory. Dysfunctions or mutations in GRIA1 have been implicated in various neurological disorders, including epilepsy and neurodegenerative diseases, making it a significant focus in neuroscience research....

GRIA1

VMP1 (Vacuole Membrane Protein 1): VMP1 is involved in autophagy, a critical cellular process for degrading and recycling cellular components. It's particularly important for the formation of autophagosomes, structures that encapsulate cellular material for degradation. Dysregulation of VMP1 can impact cellular homeostasis and is implicated in various diseases, including pancreatitis and some forms of cancer....

VMP1

VPS35L (VPS35 Retromer Complex Component Like): VPS35L is a component of the retromer complex, involved in the endosomal transport pathway crucial for recycling membrane proteins from endosomes to the Golgi apparatus or plasma membrane. While less studied than VPS35, VPS35L is believed to play a similar role in sorting and trafficking within cells, with implications for cellular homeostasis and signaling. Understanding its function is important for elucidating the mechanisms of protein recycling and its impact on various diseases, including neurodegenerative disorders....

VPS35L

GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2): GRIK2 is a critical subunit of the kainate receptors, which are glutamate-gated ion channels involved in excitatory neurotransmission in the central nervous system. These receptors play a pivotal role in synaptic transmission and plasticity, influencing learning, memory, and neural development. GRIK2's function is crucial for modulating neuronal excitability and has been implicated in various neurological conditions, including epilepsy, schizophrenia, and neurodegenerative diseases. Its involvement in the fine-tuning of synaptic activity makes GRIK2 a potential target for therapeutic interventions aimed at disorders characterized by aberrant glutamatergic signaling. Understanding the regulatory mechanisms of GRIK2...

GRIK2

VPS37B, a member of the vacuolar protein sorting (VPS) family, is a crucial component of the endosomal sorting complex required for transport (ESCRT) machinery. Located predominantly within the cytoplasm of cells, VPS37B plays a pivotal role in regulating intracellular membrane trafficking and protein sorting processes. One of the key functions of VPS37B is its involvement in the formation and function of multivesicular bodies (MVBs), specialized endosomal compartments responsible for sorting ubiquitinated membrane proteins destined for degradation in lysosomes. Within the ESCRT machinery, VPS37B interacts with other ESCRT components to facilitate the sequestration of cargo into intraluminal vesicles within MVBs, a process...

VPS37B

GRIN3A (Glutamate Ionotropic Receptor NMDA Type Subunit 3A): GRIN3A encodes a subunit of the NMDA receptor, a crucial component in synaptic plasticity and learning. As a part of the glutamate receptor family, NMDA receptors play a pivotal role in mediating neuronal communication. Their involvement in synaptic transmission and memory formation underscores their significance in neural function and neurological research....

GRIN3A

GRINA (Glia Derived Nexin): GRINA is a protein that is thought to play a critical role in the central nervous system, particularly in neuroprotection and the regulation of neuronal excitability. It is part of a larger complex involved in the modulation of NMDA (N-methyl-D-aspartate) receptors, which are essential for synaptic plasticity, memory formation, and learning. The function of GRINA is associated with its ability to influence the activity of these receptors, potentially affecting neurodevelopmental processes and neural response mechanisms. Dysregulation of GRINA has been linked to various neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia, suggesting its involvement in the...

GRINA

VWA2 (Von Willebrand Factor A Domain Containing 2): VWA2 is involved in extracellular matrix (ECM) organization and cell-matrix adhesion, playing a role in tissue development and repair. It contains a Von Willebrand factor type A domain, typically associated with mediating interactions between proteins. VWA2's function in ECM stability and cell adhesion is critical for proper tissue architecture and function, with potential relevance to wound healing and diseases characterized by ECM dysregulation....

VWA2

VWC2L (von Willebrand Factor C Domain Containing Protein 2 Like): VWC2L is a less-characterized protein with a von Willebrand factor C domain, typically involved in extracellular matrix interactions and cell adhesion processes. It might play a role in tissue development and integrity, but its specific functions in human physiology and pathology remain to be fully explored....




VWC2L

GRM1 (Glutamate Receptor, Metabotropic 1): GRM1 is a receptor for glutamate, the primary excitatory neurotransmitter in the nervous system. It plays a crucial role in modulating synaptic plasticity, learning, and memory. GRM1 is involved in various neural pathways and has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, and neurodegenerative diseases. Its role in neurotransmission and brain function makes it a potential target for therapeutic interventions in these conditions....

GRM1

WDFY2 (WD Repeat and FYVE Domain Containing 2): WDFY2 is a protein involved in endosomal sorting and trafficking. It contains both WD repeats and an FYVE domain, suggesting a role in vesicle-mediated transport processes and potentially in signaling pathways involving membrane dynamics. The specific functions of WDFY2 in cellular processes and its implications in human health and disease are still under investigation....

WDFY2

WDR70 (WD Repeat Domain 70): WDR70 is a gene that encodes a protein with a WD repeat domain, known for facilitating protein-protein interactions. This gene is implicated in various cellular processes, including cell cycle regulation and possibly RNA processing. The specific functions of WDR70 are not fully understood, but it's believed to play a role in cellular organization and function....




WDR70

BTBD7 (BTB Domain Containing 7): BTBD7 plays a key role in regulating epithelial-mesenchymal transition (EMT), a critical process in embryonic development, wound healing, and tumor metastasis. It functions by modulating the cytoskeletal architecture, thereby influencing cell shape, migration, and invasion. Dysregulation of BTBD7 has been linked to fibrosis and cancer progression, underlining its importance in tissue remodeling and its potential as a target for therapeutic intervention in fibrotic diseases and metastatic cancers....



BTBD7

WNK1 (WNK Lysine Deficient Protein Kinase 1): WNK1 is a serine/threonine kinase involved in regulating electrolyte balance and blood pressure. It affects sodium and potassium transport in the kidneys, influencing fluid balance and blood pressure. Mutations in WNK1 can lead to hereditary hypertension and electrolyte imbalances, making it a key gene in understanding certain forms of high blood pressure....




WNK1

WNT10A (Wnt Family Member 10A): WNT10A is involved in the Wnt signaling pathway, crucial for regulating cell fate determination, patterning, and morphogenesis. It plays a significant role in the development of skin, hair, teeth, and bones, with mutations leading to a range of developmental disorders....




WNT10A

BTG1 (B-cell Translocation Gene 1): BTG1 is a gene with diverse cellular roles, primarily centered around cell cycle regulation and cellular differentiation. It operates as a tumor suppressor gene in certain contexts, exerting influence over cell growth and proliferation. Beyond its tumor-suppressive functions, BTG1 also participates in various cellular processes, making it a subject of interest in cancer research and developmental biology....



BTG1

WNT7B (Wnt Family Member 7B): WNT7B is part of the Wnt signaling pathway, playing a critical role in embryonic development, cell proliferation, and differentiation. This pathway is essential for the regulation of gene expression, cellular architecture, and tissue repair. Aberrant WNT7B signaling has been associated with various pathologies, including developmental disorders, fibrosis, and cancer, particularly in the regulation of tumor growth and metastasis, emphasizing its significance in cellular growth and disease progression....

WNT7B

GRM5 (Metabotropic Glutamate Receptor 5): GRM5 is a member of the metabotropic glutamate receptor family and plays a role in neuronal signaling. It is involved in the modulation of synaptic transmission and plasticity. Dysregulation of GRM5 has been implicated in neurological disorders such as schizophrenia....

GRM5

WNT7BWNT7B (Wnt Family Member 7B): WNT7B is integral to the Wnt signaling pathway, which regulates a wide array of developmental processes, including cell growth, differentiation, and apoptosis. WNT7B is particularly important in embryonic development and the regulation of bone growth and vascularization. Abnormal WNT7B signaling has been implicated in various pathologies, including developmental disorders, fibrosis, and cancer, especially in processes like tumor growth and the aberrant formation of blood vessels. Its involvement in fundamental cellular processes underscores WNT7B's critical role in development and disease....

BTN2A2 (Butyrophilin Subfamily 2 Member A2): BTN2A2 encodes a protein belonging to the butyrophilin family, which is involved in immune regulation. These proteins can modulate immune responses, particularly in the context of T-cell activation. BTN2A2 may play a role in regulating immune reactions and could impact the immune system's ability to respond to pathogens and antigens....



BTN2A2

WSB1 (WD Repeat And SOCS Box Containing 1): WSB1 is part of the SOCS (Suppressor of Cytokine Signaling) box family, which are involved in protein degradation pathways. It plays a role in the regulation of various signaling pathways and has been implicated in responses to hypoxia and in the regulation of thyroid hormone activation....

WSB1

BTN3A2 (Butyrophilin Subfamily 3 Member A2): BTN3A2 is part of the butyrophilin protein family, which is involved in the regulation of immune responses, particularly in T cell activation and differentiation. This protein plays a role in the modulation of immune surveillance and has been implicated in autoimmune diseases and cancer. Understanding the function of BTN3A2 and its interactions with other immune components is crucial for developing therapies targeting immune regulation....



BTN3A2

WSCD1 (WSC Domain Containing 1): WSCD1 is a relatively less-characterized gene and is believed to be involved in cell wall integrity and stress response in yeast. In humans, its precise function is not well established, but it may play a role in cellular responses to environmental stress. Understanding WSCD1's function could provide insights into mechanisms of cellular adaptation and survival under stress conditions....

WSCD1

XDH, or Xanthine dehydrogenase, is an enzyme that plays a crucial role in purine metabolism, a pathway responsible for the synthesis and degradation of purine nucleotides such as adenine and guanine. XDH catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final product of purine degradation in humans. One of the primary functions of XDH is its involvement in the breakdown of purines to uric acid, a process essential for the elimination of excess purines from the body. Purines are derived from dietary sources and the breakdown of nucleic acids, and their metabolism is tightly regulated to...

C10ORF53 (Chromosome 10 Open Reading Frame 53): C10ORF53 is a gene of unknown function, identified based on its location on chromosome 10. Genes like C10ORF53 represent potential areas of interest for genetic research to uncover new biological pathways and disease associations. As research progresses, understanding the role of C10ORF53 could provide insights into cellular processes or conditions linked to this genomic region....



C10ORF53

XKR6 (XK Related 6): XKR6 is a less-characterized member of the XK family of proteins, potentially involved in transmembrane transport. Its specific function and implications in human health are not fully understood....

XKR6

XKR9 (X-Kell Blood Group Precursor-Related Family Member 9): XKR9 is a member of the X-Kell blood group precursor-related family. Its specific functions and implications are areas of ongoing research....

XKR9

C10ORF67 (Chromosome 10 Open Reading Frame 67): Also known as SASP, C10ORF67 is implicated in the regulation of cell proliferation and migration. Although its precise molecular function is not fully understood, it has been associated with the signaling pathways that contribute to cellular senescence and the senescence-associated secretory phenotype (SASP). Its role in these processes suggests potential implications for aging, cancer, and tissue regeneration studies....



C10ORF67

XXYLT1 (Xyloside Xylosyltransferase 1): XXYLT1 is involved in the post-translational modification of proteins through the addition of xylose to the serine residues of proteoglycans, a key step in the biosynthesis of glycosaminoglycan chains. This modification is crucial for the function of proteoglycans in the extracellular matrix, affecting cell signaling, adhesion, and migration. Mutations in XXYLT1 can disrupt proteoglycan function and have been linked to developmental abnormalities, underscoring its importance in cellular function and development....

XXYLT1

C11ORF21 (Chromosome 11 Open Reading Frame 21): C11ORF21 represents a gene with currently unknown specific functions. It is one of many genes that have been identified through genomic sequencing but whose roles in cellular processes and potential links to diseases are still under investigation. The study of such genes is part of ongoing research to uncover new aspects of human biology and pathology....



C11ORF21

ZBED3 (Zinc Finger BED-Type Containing 3): ZBED3 is a gene that encodes a zinc finger protein, a type of protein domain involved in gene regulation. While specific functions of ZBED3 are still being elucidated, zinc finger proteins are known to bind to DNA and influence gene expression. ZBED3 may play a role in modulating gene activity, contributing to various cellular processes and pathways....

ZBED3

C12ORF43 (Chromosome 12 Open Reading Frame 43): C12ORF43 is a protein encoded by a gene located on chromosome 12 with an open reading frame that has been identified in genomic sequencing. While its precise function and role in cellular processes are still being elucidated, studies suggest potential involvement in various biological pathways. This protein may play a role in cellular metabolism, signal transduction, or protein-protein interactions, although further research is needed to fully understand its function. Dysregulation or mutations in C12ORF43 gene expression could potentially contribute to the development of certain diseases or disorders, but specific associations have not yet...



C12ORF43

C16ORF82 (Chromosome 16 Open Reading Frame 82): Also known as FAM173B, C16ORF82 is a lesser-known gene and is currently under research to fully understand its function. Preliminary studies suggest that it may be involved in mitochondrial processes, potentially impacting energy metabolism at the cellular level. Given its mitochondrial association, it could have implications in disorders related to mitochondrial dysfunction, although more research is needed to clarify its specific role....



C16ORF82

ZBTB26 (Zinc Finger And BTB Domain Containing 26): ZBTB26 is a gene that encodes a transcription factor with zinc finger and BTB (Broad-Complex, Tramtrack, Bric-a-Brac) domains. It is involved in the regulation of gene expression and may play a role in developmental processes and immune responses. Further research is needed to fully understand its function and implications....




ZBTB26

ZBTB49 (Zinc Finger and BTB Domain Containing 49): ZBTB49 is a transcription factor that likely plays a role in gene regulation through DNA binding and chromatin remodeling. Members of the ZBTB family are involved in various cellular processes, including proliferation, differentiation, and development. While specific functions of ZBTB49 are not well-characterized, its participation in transcriptional regulation suggests it could impact cell fate decisions and has potential implications for cancer and developmental disorders....

ZBTB49

C19ORF12 (Chromosome 19 Open Reading Frame 12): C19ORF12, located on chromosome 19, encodes a protein of currently unclear function but is implicated in mitochondrial integrity and metabolism. Its significance has been underscored by its association with neurodegeneration with brain iron accumulation (NBIA), specifically mitochondrial membrane protein-associated neurodegeneration (MPAN). This protein is thought to play a role in the maintenance of mitochondrial function, possibly through involvement in lipid metabolism or the protection of mitochondrial membranes from oxidative stress. Mutations in the C19ORF12 gene have been linked to progressive neurological symptoms, including motor dysfunction, cognitive decline, and iron accumulation in the brain....



C19ORF12

ZCCHC14 (Zinc Finger, CCHC Domain Containing 14): ZCCHC14 is a gene that encodes a protein with zinc finger and CCHC domains, suggesting a role in nucleic acid binding and regulation. The specific function of ZCCHC14 is still being investigated, and further research is needed to fully understand its role in cellular processes...

ZCCHC14

C1D (Nuclear Nucleic Acid-Binding Protein C1D): C1D is a nuclear protein that is involved in nucleic acid binding and ribonucleoprotein complex assembly. It plays a role in RNA processing and transcription regulation. C1D has been studied in the context of DNA repair and may have implications in cancer biology....



ZCCHC7 (Zinc Finger CCHC-Type Containing 7): ZCCHC7 is part of the zinc finger protein family, known for roles in DNA binding and gene regulation. Its precise function is not well-defined, but like other zinc finger proteins, it may be involved in transcriptional regulation, RNA processing, or DNA repair processes, impacting various cellular functions and potentially playing a role in disease mechanisms....




ZCCHC7

C1ORF87 (Chromosome 1 Open Reading Frame 87): C1ORF87 is a lesser-characterized gene, and its function in human biology is not fully established. Genes identified as "open reading frames" (ORFs) are often subjects of ongoing research to determine their roles in cellular processes and their potential implications in health and disease....



C1ORF87

ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20): ZDHHC20 is a member of the DHHC family of palmitoyltransferases, enzymes responsible for the post-translational modification known as protein palmitoylation. This process involves the attachment of a fatty acid, palmitate, to specific cysteine residues of target proteins, thereby modulating their cellular localization, stability, and function. ZDHHC20 specifically catalyzes the palmitoylation of target proteins, influencing their membrane association and intracellular trafficking. Through its regulatory role in protein palmitoylation, ZDHHC20 contributes to diverse cellular processes such as signal transduction, synaptic plasticity, and membrane trafficking. Dysregulation of ZDHHC20 activity has been implicated in various neurological disorders, including...

ZDHHC20

ZFAT (Zinc Finger And AT-Hook Domain Containing): ZFAT is a transcription factor believed to play a role in immune function and cell survival. It has been implicated in autoimmune diseases and is studied for its role in lymphocyte development and function....

ZFAT

ZFP57 (ZFP57 Zinc Finger Protein): ZFP57 is a KRAB-zinc finger protein involved in the regulation of genomic imprinting and methylation. It's essential for maintaining the epigenetic stability of imprinted genes during early embryonic development. Mutations in ZFP57 have been linked to transient neonatal diabetes and other imprinting disorders, underscoring its role in epigenetic regulation and developmental processes....

ZFP57

C1QL3 (Complement C1q Like Protein 3): C1QL3 is a member of the C1q/tumor necrosis factor-related protein family, potentially involved in immune and inflammatory responses. Its exact physiological role is still being explored, but it may have implications in immune system modulation and neuroinflammation....



C1QL3

ZFP64 (ZFP64 Zinc Finger Protein): ZFP64 is a zinc finger protein involved in gene regulation. Zinc finger proteins can bind to specific DNA sequences and modulate gene expression. The precise targets and functions of ZFP64 in cellular processes are areas of ongoing investigation....




ZFP64

C1QTNF6 (C1q And TNF Related 6): C1QTNF6 is a member of the C1q/tumor necrosis factor-related protein family, involved in modulating inflammatory responses, adipose tissue metabolism, and cell survival pathways. It plays a role in the regulation of insulin sensitivity and energy homeostasis, with emerging evidence suggesting its contribution to metabolic syndromes, including obesity and diabetes. The function of C1QTNF6 in inflammation and metabolism highlights its potential impact on chronic disease development....



C1QTNF6

GSDMB (Gasdermin B): GSDMB is part of the gasdermin family, which is involved in the regulation of cell death and inflammation. It has been associated with susceptibility to asthma and autoimmune diseases. GSDMB's role in inflammatory responses makes it a potential target for therapeutic interventions in these conditions....

GSDMB

ZFPM1 (Zinc Finger Protein, FOG Family Member 1): ZFPM1, also known as FOG-1, is a cofactor that interacts with GATA family transcription factors, playing a crucial role in the development and differentiation of various cell types, including those in the heart and blood. It is particularly important for erythroid and megakaryocyte differentiation. Mutations or dysregulation of ZFPM1 can affect hematopoiesis, leading to blood disorders. Additionally, ZFPM1's involvement in cardiac development implicates it in congenital heart defects. Research on ZFPM1 focuses on understanding its role in the intricate network of gene regulation governing cell fate decisions, with implications for treating related...

PTPRC

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