RGS17 (Regulator Of G Protein Signalling 17): RGS17 is a gene that encodes a protein from the regulator of G protein signalling (RGS) family. These proteins help control G protein-coupled receptor (GPCR) signalling by accelerating the conversion of GTP to GDP. RGS17 may influence multiple GPCR-regulated pathways, affecting a range of physiological processes.