RNF220 (Ring Finger Protein 220): RNF220 is a protein that belongs to the ring finger family, recognised for its ring finger domain involved in protein interactions and ubiquitination. It functions as an E3 ubiquitin ligase, playing a key role in the ubiquitin-proteasome system responsible for protein degradation and cellular homeostasis. RNF220 helps regulate important cellular activities such as signal transduction, gene expression, and the cell cycle. Disruptions in RNF220 function have been linked to diseases including cancer and neurodegenerative disorders.