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GetTested’s Food Intolerance Test 240 items analyzes IgG4 antibodies for 240 different foods often involved in hypersensitivity reactions. Unlike allergic reactions that are instant, symptoms from food intolerance can occur hours to days later, making it difficult to link to the foods you’ve eaten.

<p>GetTested’s Food Intolerance Test 240 items analyzes IgG4 antibodies for 240 different foods often involved in hypersensitivity reactions. Unlike allergic reactions that are instant, symptoms from food intolerance can occur hours to days later, making it difficult to link to the foods you’ve eaten.</p>

Food Intolerance 240 items

RWDD3 (RWD Domain Containing 3): RWDD3 is a protein with a poorly characterized function. Its specific role in cellular processes and its relevance to human health and disease are still areas of ongoing research....

RWDD3

MEIS1 (Meis Homeobox 1): MEIS1 is a transcription factor that is involved in early embryonic development and organogenesis. It plays a role in limb development and hematopoiesis. MEIS1 has been associated with restless legs syndrome (RLS) and has implications in neurological and developmental disorders....



MEIS1

VEGFC, or Vascular Endothelial Growth Factor C, is a crucial protein involved in the regulation of lymphangiogenesis, the formation of lymphatic vessels, and angiogenesis, the formation of blood vessels. As a member of the vascular endothelial growth factor (VEGF) family, VEGFC plays diverse roles in physiological and pathological processes, including embryonic development, tissue repair, and tumor progression. One of the primary functions of VEGFC is its ability to stimulate the growth and proliferation of lymphatic endothelial cells, promoting the formation and remodeling of lymphatic vessels. VEGFC binds to and activates its receptors, primarily VEGFR-3 (vascular endothelial growth factor receptor 3), initiating...



VEGFC

MAGI3 (Membrane Associated Guanylate Kinase, WW, and PDZ Domain Containing 3): MAGI3 is a scaffolding protein involved in the assembly of multiprotein complexes at cell junctions and in signal transduction pathways. It's implicated in cellular processes like epithelial cell polarity and may play a role in cancer development, particularly in the context of cell-cell adhesion and signaling....

MAGI3

MITF (Melanocyte Inducing Transcription Factor): MITF is crucial for the development and function of melanocytes, cells responsible for pigment production. Mutations in MITF can lead to pigmentary disorders and increase the risk of melanoma, a type of skin cancer. MITF also plays a role in the development of certain types of retinal cells and has been implicated in Waardenburg syndrome....



MITF

NRXN1 (Neurexin 1): NRXN1 is a neuronal cell adhesion molecule involved in synapse formation and function. It plays a significant role in neural communication and has been linked to a variety of neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, and intellectual disability....



NRXN1

Allergies

Willow trees release pollen early in the spring, contributing to seasonal allergy symptoms for many individuals. The light, easily dispersed pollen can provoke an immune response in those with a sensitivity to willow, leading to discomfort during what is often a beautiful time of year....

Willow

RTN4 (Reticulon 4): RTN4, also known as Nogo, is a protein known for its role in inhibiting nerve fiber growth and regeneration in the central nervous system. It's significant in the context of spinal cord injury and neurodegenerative diseases, as it impedes the ability of axons to regrow after injury. RTN4 has been a target in research seeking to promote neural regeneration and repair....

RTN4

OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like): OPCML is a glycosylphosphatidylinositol-anchored protein involved in cell adhesion and signaling. It has been identified as a tumor suppressor, with its expression frequently downregulated in various cancers, suggesting a protective role against tumor development and progression....



OPCML

EDA2R, also known as Ectodysplasin A2 receptor, is a protein encoded by the EDA2R gene. It belongs to the tumor necrosis factor receptor (TNFR) superfamily and serves as a receptor for ectodysplasin A2 (EDA-A2), a signaling molecule involved in the development of ectodermal tissues such as hair, teeth, and sweat glands. One of the primary functions of EDA2R is its role in mediating the effects of EDA-A2 signaling during embryonic development. EDA-A2, also known as ectodysplasin A2 or EDA2, is a ligand that binds to EDA2R, initiating signaling cascades that regulate the formation and patterning of ectodermal structures. This signaling pathway...



EDA2R

MKNK2 (MAP Kinase Interacting Serine/Threonine Kinase 2): MKNK2 encodes a kinase that interacts with MAP kinases and plays a role in the regulation of protein synthesis. It is involved in various cellular processes, including stress responses and inflammation. Dysregulation of MKNK2 has been linked to cancer and other diseases involving aberrant signaling pathways....



MKNK2

RPS20 (Ribosomal Protein S20): RPS20 is a ribosomal protein involved in ribosome assembly and protein synthesis. It is a component of the small ribosomal subunit and plays a crucial role in translation. Mutations in ribosomal proteins like RPS20 can lead to ribosomopathies, a group of disorders characterized by defective ribosome function and developmental abnormalities....




RPS20

`TMEM171 (Transmembrane Protein 171): TMEM171 is a gene that encodes a transmembrane protein. While its precise functions and roles in cellular processes are not fully characterized, transmembrane proteins are often involved in cell signaling, transport of molecules across cell membranes, and cellular communication. Further research is needed to uncover the specific functions of TMEM171 in cellular biology....`

TMEM171

RTL1 (Retrotransposon Like 1): RTL1 is a gene thought to be derived from a retrotransposon and is involved in placental development. It has imprinted expression, meaning it is expressed from only one parental allele. Dysregulation of RTL1 can have implications in diseases related to genomic imprinting, such as Beckwith-Wiedemann syndrome....




RTL1

SERTAD2 (SERTA Domain Containing 2): SERTAD2 is a multifunctional protein that contains a SERTA domain, which is associated with cell cycle regulation. Beyond its role in cell cycle progression, SERTAD2 is involved in intricate cellular processes such as DNA replication, DNA repair, and chromatin remodeling. Its ability to interact with various transcription factors and co-regulators makes it a pivotal player in orchestrating gene expression. ...

SERTAD2

MECOM (MDS1 and EVI1 Complex Locus): MECOM is a transcriptional regulator implicated in hematopoiesis and the development of certain cancers, particularly myeloid leukemia. It encodes EVI1, a protein involved in gene regulation, cell proliferation, and differentiation....



MECOM

Rosemary, a fragrant and aromatic herb used to flavor a wide range of dishes, is known for its distinctive scent and flavor profile. However, some individuals may experience rosemary intolerance, impacting their ability to consume rosemary without discomfort....

Salmon caviar

RSU1 (Ras Suppressor Protein 1): RSU1 is a protein that interacts with various signaling molecules, including Ras. It is involved in regulating cell adhesion and motility. RSU1 plays a role in cell signaling pathways and may have implications in cancer progression and metastasis....

RSU1

SERPINE2 (Serpin Family E Member 2): SERPINE2, also known as protease nexin-1, is a serine protease inhibitor with broad specificity, playing a significant role in regulating proteolytic pathways involved in tissue remodeling, fibrinolysis, and neuronal growth. It inhibits thrombin and urokinase-type plasminogen activator, crucial for blood clotting and tissue repair processes. Dysregulation of SERPINE2 has been associated with various cardiovascular and neurological disorders, highlighting its role in maintaining tissue integrity and function....




SERPINE2

RPA2 (Replication Protein A2): RPA2, a subunit of the Replication Protein A (RPA) complex, serves as a crucial player in DNA replication, repair, and recombination processes within the cell. As part of the RPA complex, RPA2 functions in the stabilization and protection of single-stranded DNA (ssDNA) intermediates, facilitating the progression of DNA replication forks and safeguarding genomic integrity. By binding to exposed ssDNA regions, RPA2 prevents their degradation and promotes the recruitment of other DNA repair proteins, thereby orchestrating efficient DNA damage response pathways. Moreover, RPA2 participates in various cellular processes beyond DNA replication, including telomere maintenance, DNA damage checkpoint...

RPA2

SERPINB10 (Serpin Family B Member 10): SERPINB10 is a member of the serpin family of protease inhibitors and plays a role in regulating protease activity in various biological processes. Its specific functions and implications in human disease are not fully understood....

SERPINB10

Minerals

Iodine is a vital mineral essential for thyroid health, playing a crucial role in producing thyroid hormones. These hormones regulate metabolism, growth, and energy production. While iodine occurs naturally in seafood, dairy, and some grains, deficiency is common, especially in areas with iodine-poor soil. Insufficient iodine can lead to thyroid disorders, impacting overall health. It's important to ensure adequate iodine intake for proper bodily functions....

Iodine

MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1): MAP3K1 is involved in the MAPK signaling pathway, which regulates various cellular processes, including proliferation, differentiation, and response to stress. Mutations in this gene can lead to developmental disorders and are implicated in various cancers....

MAP3K1

SERPINA7, also known as Thyroxine-binding globulin (TBG), is a crucial carrier protein primarily synthesized in the liver and circulates in the bloodstream. Its primary function is to bind to and transport thyroid hormones, particularly thyroxine (T4) and triiodothyronine (T3), throughout the body. This glycoprotein plays a pivotal role in regulating the availability and distribution of thyroid hormones, which are essential for various physiological processes, including metabolism, growth, and development. By tightly binding to thyroid hormones, SERPINA7 helps to maintain their concentration within the bloodstream, ensuring efficient delivery to target tissues and organs. Moreover, alterations in SERPINA7 levels or mutations in its encoding...




SERPINA7

Allergies to fruits such as kiwi, mango, and banana are increasingly recognized and can cause discomfort and severe reactions in sensitive individuals. These allergies stem from the body's immune system reacting to specific proteins found in these fruits, leading to a range of symptoms. Recognizing these allergies and managing them effectively is vital for maintaining health and well-being....

Kiwi, Mango, Banana

SERPINA1 (Serpin Family A Member 1): SERPINA1, also known as alpha-1-antitrypsin, is a major protease inhibitor, primarily produced in the liver, and plays a vital role in protecting the lungs from neutrophil elastase. Deficiency in SERPINA1 can lead to alpha-1 antitrypsin deficiency, a genetic disorder that causes lung diseases like emphysema and chronic obstructive pulmonary disease (COPD), as well as liver diseases. It is crucial in maintaining the balance of proteolytic activity in lung tissues....

SERPINA1

NRSN1 (Neurensin 1): NRSN1 is a neuronal protein that may be involved in synaptic function and plasticity. While its exact role in the brain is not fully characterized, it is thought to contribute to the regulation of neurotransmitter release and neuronal signaling, with implications for learning and memory....



NRSN1

Fertility Markers

Anti-Müllerian Hormone (AMH) is a hormone produced by the ovaries that reflects a woman's ovarian reserve, indicating the number of eggs remaining in her ovaries. It helps assess fertility potential and is often measured in reproductive medicine....



Anti-Müllerian Hormone (AMH)

hCG, or human chorionic gonadotropin, is a hormone produced by the placenta during pregnancy. Its primary role is to support the development of the corpus luteum, which, in turn, produces progesterone to maintain the uterine lining for the embryo. hCG also plays a crucial role in preventing the degeneration of the corpus luteum, ensuring the continued production of progesterone....

* 

NRP2 (Neuropilin 2): NRP2 is a receptor involved in angiogenesis and lymphangiogenesis, as well as in neuronal guidance. It binds to vascular endothelial growth factors and semaphorins, influencing blood vessel and nerve development. NRP2 has implications in cancer progression, particularly in tumor angiogenesis and metastasis, and in developmental processes....



NRP2

STIs

Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium Chlamydia trachomatis. It can infect both men and women and can cause serious, permanent damage to a woman's reproductive system, potentially leading to infertility. Chlamydia can also cause a potentially fatal ectopic pregnancy (pregnancy that occurs outside the womb)....



Chlamydia

MDM1 (MDM1 Nuclear Protein Homolog): MDM1 is a nuclear protein with a speculated role in the regulation of chromosomal integrity during cell division. It may be involved in DNA repair mechanisms or in the response to DNA damage. The precise cellular functions of MDM1 remain a subject of ongoing research, particularly in the context of cell cycle regulation. ...



MDM1

NRIP1 (Nuclear Receptor Interacting Protein 1): NRIP1 is a gene that encodes a protein involved in nuclear receptor signaling. It functions as a coactivator for various nuclear receptors, including estrogen receptors (ERs) and peroxisome proliferator-activated receptors (PPARs). NRIP1 plays a role in regulating gene expression in response to hormonal signals and is associated with processes such as metabolism and cell growth....



NRIP1

Gardnerella, specifically referring to Gardnerella vaginalis, is a type of bacteria that is often associated with bacterial vaginosis (BV), a common vaginal infection. While Gardnerella is a normal part of the vaginal flora, an imbalance can lead to an overgrowth, resulting in BV. It is not considered a classic sexually transmitted infection (STI), but its occurrence can be influenced by sexual activity....



Gardnerella

Shellfish allergies are among the most common food allergies, affecting both adults and children. This type of allergy often encompasses a range of shellfish, including blue mussel, oyster, clam, and scallop. Due to the potential severity of allergic reactions, understanding how to identify and manage an allergy to these shellfish is essential for those affected....



Blue Mussel, Oyster, Clam, Scallop

Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae. It commonly affects the urethra, rectum, and throat, and in women, it can also infect the cervix. Gonorrhea is a common infection, especially among young people aged 15-24 years. It can lead to serious health problems and complications if not treated....



Gonorrhea

Toxic elements

Barium is a soft, silvery metal used in various industries, including manufacturing and medical diagnostics. While barium sulfate in medical imaging is safe, exposure to soluble barium compounds can be harmful, affecting the heart, causing muscle weakness, and damaging the kidneys and liver. Industrial workers and individuals near barium processing plants are at increased risk of exposure through inhalation or water contamination....



Barium

Cacao, the primary ingredient in chocolate, is beloved by many but can also be a source of allergies for some individuals. An allergy to cacao can manifest through various symptoms ranging from mild to severe, including skin reactions, gastrointestinal discomfort, respiratory issues, and, in rare cases, anaphylaxis. Understanding your body's response to cacao and related products is crucial for maintaining health and well-being....

Cacao

HIV attacks the immune system, weakening the body's defense against infections. It's transmitted through bodily fluids, notably during unprotected sex or needle sharing. Early HIV might not show symptoms, making testing crucial. While there's no cure, antiretroviral therapy can manage the virus effectively. Prevention includes regular testing and prophylaxis medications like PrEP and PEP. Public health efforts emphasize education and stigma reduction....



Mycoplasma, particularly Mycoplasma hominis (MH), is a type of bacteria that can be transmitted through sexual contact, although it is not strictly classified as a sexually transmitted infection (STI). It is one of several species of Mycoplasma that affect humans and can inhabit the genital and respiratory tracts. While often asymptomatic, it can cause health problems, particularly in the genitourinary tract....



Mycoplasma (MH)

LDLRAD3 (Low Density Lipoprotein Receptor Class A Domain Containing 3): This gene encodes a protein that is believed to be involved in lipid metabolism and transport. It shares similarities with low-density lipoprotein receptors, suggesting a role in cholesterol homeostasis. Its exact function, however, remains less understood....

LDLRAD3

RRAGC (Ras Related GTP Binding C): RRAGC is a member of the small GTPase family and plays a role in amino acid sensing and mTOR signaling. This gene is important for cellular growth, proliferation, and metabolic regulation. Dysregulation of RRAGC can impact cellular energy balance and has been linked to metabolic disorders....




RRAGC

TFPI2 (Tissue Factor Pathway Inhibitor 2): TFPI2, a critical component of the coagulation cascade, acts as a potent inhibitor of the tissue factor (TF)-mediated blood coagulation pathway. It plays a significant role in maintaining hemostatic balance by preventing excessive thrombosis and modulating fibrinolysis. Located in the extracellular matrix (ECM), TFPI2 is involved in various physiological processes beyond coagulation, including cell migration, proliferation, and angiogenesis, contributing to tissue repair and remodeling. The aberrant expression of TFPI2 has been associated with numerous pathological conditions, including cancer, where it may act as a tumor suppressor gene. Its downregulation in certain cancers has been...



TFPI2

TIMP4 (TIMP Metallopeptidase Inhibitor 4): TIMP4 is involved in the regulation of metalloproteinases, which are enzymes that degrade extracellular matrix components. It plays a role in tissue remodeling and is important in processes like wound healing and angiogenesis....



TIMP4

NR1H3: NR1H3 encodes the liver X receptor alpha, a nuclear receptor that regulates the expression of genes involved in cholesterol and lipid metabolism. It plays a critical role in maintaining cholesterol homeostasis and has been implicated in the development of atherosclerosis and other metabolic disorders....



NR1H3

NPC1 (Niemann-Pick Disease, Type C1): NPC1 is crucial for cholesterol trafficking within cells. Mutations in this gene cause Niemann-Pick disease type C, a rare genetic disorder characterized by the accumulation of cholesterol and other lipids in cells, leading to neurodegeneration and liver dysfunction....



NPC1

NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1): NR3C1 encodes the glucocorticoid receptor, which mediates the effects of glucocorticoids, a class of steroid hormones. This receptor is involved in diverse processes including stress response, immune function, and metabolism. Dysregulation of NR3C1 is associated with various stress-related disorders, inflammatory conditions, and metabolic diseases. It plays a crucial role in the body's response to stress and inflammation, making it a significant target in the treatment of a range of conditions from autoimmune diseases to psychiatric disorders....



NR3C1

NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2): NR4A2, also known as Nurr1, is a transcription factor essential for the development and maintenance of dopaminergic neurons in the brain. It's involved in neuroprotection and has been studied in relation to Parkinson's disease and other neurodegenerative disorders....



NR4A2

NRG1 (Neuregulin 1): NRG1 is a signaling protein that is involved in neural development and synaptic plasticity. It plays a crucial role in the development of the nervous system and has been implicated in various neurological and psychiatric disorders, including schizophrenia....



NRG1

NRBF2, also known as Nuclear Receptor Binding Factor 2, is a protein involved in autophagy, a cellular process responsible for degrading and recycling damaged or unnecessary cellular components. NRBF2 plays a crucial role in the regulation of autophagy by facilitating the formation of autophagosomes, double-membraned vesicles that engulf and sequester cellular cargo for degradation. One of the primary functions of NRBF2 is its interaction with the autophagy-initiating kinase complex, ULK1 (Unc-51 Like Autophagy Activating Kinase 1) complex. NRBF2 binds to the ULK1 complex, which consists of ULK1, ATG13, FIP200, and ATG101, and promotes its stability and activity. This interaction is essential...



NRBF2

MDGA1 (MAM Domain Containing Glycosylphosphatidylinositol Anchor 1): MDGA1 is involved in neural development and cell adhesion. It plays a role in axon guidance and may have implications in neural connectivity and synaptic function....



MDGA1

XYLT1 (Xylosyltransferase 1): XYLT1 is an enzyme involved in the biosynthesis of proteoglycans, which are important components of the extracellular matrix. It adds xylose to specific serine residues in proteoglycans, a crucial step in the formation of connective tissues. Mutations in XYLT1 can lead to skeletal and connective tissue disorders, highlighting its role in tissue development and maintenance....

XYLT1

NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing): NRDE2 is a less-characterized gene believed to be involved in RNA interference, a process that regulates gene expression. It may play a role in the regulation of genes post-transcriptionally, affecting various cellular processes....



NRDE2

ZNF516 (Zinc Finger Protein 516): ZNF516 is a KRAB zinc finger protein, which suggests a role in DNA binding and transcriptional regulation. It's implicated in the regulation of cardiac genes and has been studied in relation to cardiovascular diseases. Dysregulation of ZNF516 may influence cardiac development and function, with potential implications for heart disease and heart failure....




ZNF516

NUP62CL (Nucleoporin 62 C-Terminal Like): NUP62CL is a gene involved in the nuclear pore complex, a critical structure in the nuclear envelope that regulates the transport of molecules between the nucleus and cytoplasm. Alterations in NUP62CL can affect nuclear transport and have potential implications in neurodegenerative diseases and cancers....



NUP62CL

MDFIC2: MDFIC2, or MyoD Family Inhibitor Domain Containing 2, is a gene not extensively studied but believed to be involved in muscle development and differentiation. It may play a role in the regulation of myogenic factors, which are critical for muscle cell growth and repair. Understanding MDFIC2's function could provide insights into muscle development disorders or muscle regeneration processes....



MDFIC2

MORC4 (MORC Family CW-Type Zinc Finger 4): MORC4 is involved in chromatin remodeling and gene expression regulation. This gene has implications in cellular processes like DNA repair and apoptosis. Mutations or dysfunctions in MORC4 could be linked to various cancers and developmental disorders, making it a focus in the study of gene regulation and cancer biology....



MORC4

NUDT9 (Nudix Hydrolase 9): NUDT9 encodes a member of the Nudix hydrolase family, which is involved in the hydrolysis of nucleoside diphosphate derivatives. Its specific substrates and functions are still being elucidated....



NUDT9

NCLN (Nicalin): NCLN is a part of the nicalin-NOMO (nodal modulator) complex, which is involved in various cellular processes including signaling pathways that regulate embryonic development and organogenesis. While the specific functions of NCLN are still being elucidated, it is thought to play a role in modulating signaling pathways such as the Nodal signaling, important for patterning and development. NCLN's function and its complex suggest its potential involvement in developmental disorders and diseases related to signaling pathway dysregulation....

NCLN

NR2F2 (Nuclear Receptor Subfamily 2 Group F Member 2): NR2F2, also known as COUP-TFII, is a transcription factor involved in the development and function of several organs, including the heart and vascular system. It regulates genes involved in angiogenesis (formation of new blood vessels) and metabolic processes. Abnormal NR2F2 function has implications in developmental disorders and various cancers, where it can influence tumor growth and metastasis....



NR2F2

NAA38 (N-Alpha-Acetyltransferase 38, NatC Catalytic Subunit): NAA38, also known as MAK3, is part of the N-terminal acetyltransferase complex that catalyzes the transfer of acetyl groups to the N-terminus of proteins, a modification affecting protein stability, localization, and function. While the specific biological roles of NAA38 and its substrate specificity are not fully understood, N-terminal acetylation is a widespread and important post-translational modification. Studying NAA38 and related enzymes can provide insights into the regulatory mechanisms of protein function and the implications of protein acetylation in cellular processes and diseases....

NAA38

Meat allergy occurs when the immune system mistakenly identifies certain proteins found in meat as harmful, triggering an allergic reaction. Unlike food intolerances that primarily affect digestion, meat allergies can cause a wide range of symptoms, from mild to severe....

Meat (pork, beef, chicken, lamb)

MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase): MTR is a critical enzyme involved in the remethylation pathway of homocysteine metabolism. This enzyme catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5-MTHF) to homocysteine, generating methionine and tetrahydrofolate (THF). Methionine serves as a precursor for S-adenosylmethionine (SAM), a universal methyl donor essential for various methylation reactions in the body, including DNA methylation, neurotransmitter synthesis, and histone modification. The remethylation of homocysteine by MTR is a vital process for maintaining normal homocysteine levels and ensuring an adequate supply of methyl groups for cellular methylation reactions. Dysregulation of MTR activity, often due to genetic mutations or deficiencies...



Dust mite allergen, which is a common indoor allergen causing respiratory issues and skin reactions.

Mite

Understanding the role of Cross-reactive Carbohydrate Determinants (CCDs) in allergy testing is crucial for accurately diagnosing allergies. CCDs are complex sugar structures found on the surface of plant and animal proteins that can lead to false-positive results in allergy tests....



CCD (Cross-reactive Carbohydrate Determinants)

NR5A2 (Nuclear Receptor Subfamily 5 Group A Member 2): NR5A2, also known as LRH-1, is a nuclear receptor involved in a wide range of physiological processes, including cholesterol homeostasis, bile acid synthesis, and steroidogenesis. It is also implicated in pancreatic development and function. Dysregulation of NR5A2 has been associated with various cancers, particularly gastrointestinal cancers, and metabolic disorders....



NR5A2

Oak trees are prolific pollen producers and a major source of springtime allergies. When they release pollen, it can provoke significant allergic responses in people with sensitivities. Oak pollen season often leads to an increase in allergy and asthma symptoms due to the high pollen counts....

NPSR1 (Neuropeptide S Receptor 1): NPSR1 is a G protein-coupled receptor for neuropeptide S, playing a role in regulating arousal, anxiety, and other behavioral responses. It has been studied for its involvement in sleep-wake regulation and its potential role in psychiatric disorders such as anxiety and panic disorder. Variations in NPSR1 have been linked to susceptibility to asthma and other inflammatory diseases, suggesting its broader implications in health and disease....



NPSR1

Cheddar cheese allergy is primarily related to milk allergy, as cheddar is a dairy product made from cow's milk. Individuals allergic to cow's milk are likely to react to cheddar cheese due to the proteins it contains, such as casein and whey. Recognizing the symptoms and understanding how to manage a cheddar cheese allergy are essential steps for those affected....



Cheddar cheese

SLC1A7 (Solute Carrier Family 1 Member 7): SLC1A7 is a high-affinity glutamate transporter, primarily involved in the clearance of glutamate from the synaptic cleft. Its role is crucial in preventing excitotoxicity, a condition where excessive glutamate causes neuronal damage. While less studied than other glutamate transporters, SLC1A7 contributes to the regulation of glutamatergic signaling, with potential implications for neurological conditions characterized by dysregulated glutamate neurotransmission....



SLC1A7

Grass pollen that is a significant cause of seasonal allergies, especially in late spring and early summer.

Bahia grass pollen

Antimony, used in flame retardants, electronics, and alloys, can be toxic if inhaled or ingested. Main risks include respiratory irritation, skin problems, and, in severe cases, heart and lung issues. Those working in industries that use antimony or living near manufacturing sites have higher exposure risks. Using appropriate safety equipment and monitoring air and water quality can help prevent antimony toxicity....



Antimony

Pollen from ribwort plantain, a type of plant that can trigger respiratory allergies, especially in summer.

Ribwort plantain pollen

Maple leaf sycamore, also known as sycamore maple, is a significant source of springtime allergies. Its pollen can irritate those with sensitivities, leading to seasonal allergic rhinitis. Symptoms often flare up on sunny, breezy days when pollen is most abundant in the air....

Maple Leaf Sycamore

Dermatophagoides pteronyssinus, commonly known as the European house dust mite, is a prevalent source of indoor allergies. These microscopic creatures thrive in warm, humid environments and feed on organic matter like flakes of shed human skin. Their waste products and body fragments can trigger allergic reactions and asthma in sensitive individuals....



Dermatophagoides pteronyssinus (D. pteronyssinus)

NR3C2, also known as Nuclear Receptor Subfamily 3 Group C Member 2 or mineralocorticoid receptor (MR), is a nuclear receptor protein that plays a crucial role in the regulation of electrolyte balance and blood pressure homeostasis. Positioned predominantly within the cytoplasm of target cells, NR3C2 functions as a ligand-activated transcription factor that mediates the effects of mineralocorticoid hormones, such as aldosterone. One of the primary functions of NR3C2 is its involvement in the regulation of sodium and potassium ion transport in the kidney, colon, and salivary glands. Upon binding to aldosterone, NR3C2 undergoes a conformational change and translocates into the nucleus,...



NR3C2

Heavy Metals

Cobalt is a trace mineral that plays a pivotal role in the body as part of vitamin B12, crucial for nerve function, red blood cell production, and DNA synthesis. While cobalt itself is not directly ingested, its presence in vitamin B12 is essential for maintaining overall health. Deficiency in cobalt, though rare, can lead to symptoms similar to vitamin B12 deficiency, impacting energy levels and cognitive function. While cobalt is essential in small amounts, excessive exposure can lead to serious health issues. These include respiratory difficulties, heart complications, and thyroid dysfunction. In high concentrations, cobalt can become toxic, particularly harming the...




Cobalt

CACNA1D (Calcium Voltage-Gated Channel Subunit Alpha1 D): CACNA1D encodes a subunit of the L-type voltage-dependent calcium channel, which is crucial in regulating calcium influx in various types of cells, particularly in muscle and nerve cells. Mutations in this gene are associated with disorders like autism spectrum disorders, epilepsy, and certain types of cardiac dysfunctions....

CACNA1D

Silicon, a trace mineral, strengthens bones and boosts skin, hair, and nail health. It's found in grains, fruits, and vegetables, making it easy to include in your diet. Silicon also plays a role in preventing osteoporosis by enhancing bone mineral density....

Silicon

NOX4 (NADPH oxidase 4): NOX4 is a member of the NADPH oxidase family of enzymes, which play essential roles in generating reactive oxygen species (ROS) within cells. Unlike other NADPH oxidases, NOX4 exhibits constitutive activity, meaning it generates ROS continuously under basal conditions. This enzyme is primarily localized to the endoplasmic reticulum and plasma membrane, where it catalyzes the transfer of electrons from NADPH to molecular oxygen, leading to the production of superoxide radicals (O2•−). ROS generated by NOX4 serve as signaling molecules involved in various physiological processes, including cell proliferation, differentiation, and apoptosis. Additionally, NOX4-derived ROS play critical roles in...



NOX4

MYH11 (Myosin Heavy Chain 11): MYH11 encodes a smooth muscle myosin heavy chain, a key component of the contractile apparatus in smooth muscle cells. This protein plays a pivotal role in the contraction and relaxation of smooth muscle fibers, which is fundamental to various physiological processes, including vascular regulation, gastrointestinal motility, and respiratory function. MYH11 is essential for maintaining the structural integrity and function of smooth muscle tissues across the body. Mutations or dysregulation in the MYH11 gene can lead to a range of vascular disorders, including thoracic aortic aneurysms and dissections, highlighting its critical role in vascular health. The...

MYH11

TRIM69 (Tripartite Motif Containing 69): TRIM69 is part of the TRIM protein family, which is involved in various cellular processes, including viral defense, regulation of transcription, and cell cycle control. TRIM69 has been studied for its role in antiviral response and immune regulation. It has the potential to influence the innate immune system by modulating the activity of key signaling pathways. Research into TRIM69 aims to uncover its specific mechanisms of action and its impact on disease resistance and immune function....

TRIM69

SLC25A2 (Solute Carrier Family 25 Member 2): SLC25A2 encodes a member of the solute carrier family of mitochondrial transport proteins, specifically involved in the transport of ornithine across the mitochondrial membrane. This process is crucial in the urea cycle and amino acid metabolism. Dysfunctions in this gene can lead to metabolic disorders, highlighting its importance in understanding metabolic pathways and potential therapeutic targets for related diseases....

2SLC25A2

NQO1 (NAD(P)H Quinone Dehydrogenase 1): NQO1 is an enzyme that protects cells from oxidative stress by catalyzing the reduction of quinones to hydroquinones. This activity helps to prevent the formation of reactive oxygen species and maintains cellular redox homeostasis. Polymorphisms in NQO1 have been linked to an increased risk of various cancers and susceptibility to toxin-induced toxicities, emphasizing its role in cellular protection and detoxification....



NQO1

ABCG5 (ATP Binding Cassette Subfamily G Member 5): ABCG5 is part of the ATP-binding cassette transporter family and plays a crucial role in the regulation of dietary cholesterol. It functions in tandem with another gene, ABCG8, to limit intestinal absorption and promote the excretion of sterols from the body. Mutations in ABCG5 are associated with sitosterolemia, a rare disorder characterized by high levels of plant sterols in blood, leading to atherosclerosis and other cardiovascular issues...

ABCG5

ABT1, also known as Activator of Basal Transcription 1, is a protein that plays a critical role in the regulation of gene expression by promoting the initiation of transcription. It is a component of the RNA polymerase I (Pol I) transcription machinery, which is responsible for transcribing ribosomal RNA (rRNA) genes to generate ribosomal RNA transcripts. One of the primary functions of ABT1 is its role as a transcription factor that binds to specific DNA sequences within the promoter regions of rRNA genes. By binding to these promoter sequences, ABT1 recruits other transcription factors and the RNA polymerase I complex to...

ABT1

ACKR1 (Atypical Chemokine Receptor 1): ACKR1, formerly known as Duffy antigen receptor for chemokines (DARC), acts as a decoy receptor that binds chemokines without signaling. It modulates the immune response by sequestering chemokines, affecting leukocyte migration. ACKR1 is also known for its role in malaria resistance, as it serves as a receptor for Plasmodium vivax. Variations in ACKR1 can influence susceptibility to infection and autoimmune diseases, highlighting its role in immunity and disease....

ACKR1

ACKR1 (Atypical Chemokine Receptor 1): ACKR1, formerly known as DARC (Duffy Antigen Receptor for Chemokines), acts as a decoy receptor for chemokines, modulating the immune response and inflammatory pathways. Unlike typical chemokine receptors, ACKR1 does not signal intracellularly but serves to sequester chemokines, reducing their availability to signal through conventional chemokine receptors. This unique mechanism plays a role in the regulation of inflammation and in protecting tissues from excessive damage during immune responses. Variations in ACKR1 are associated with susceptibility to infection and the severity of inflammatory diseases....

Amino Acids

Alanine, a nonessential amino acid, plays a crucial role in the body's metabolism. It's involved in the transfer of nitrogen from peripheral tissues to the liver, aiding in glucose production during fasting states. This amino acid is synthesized in the body and found in a variety of dietary sources, making it accessible for bodily functions....

Alanine

ADAMTS16 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 16): ADAMTS16 is an enzyme involved in the cleavage of extracellular matrix components. It plays a role in tissue remodeling and development. Dysregulation of ADAMTS16 has been associated with various conditions, including kidney and cardiovascular diseases, and it may have implications in fertility....

ADAMTS16

NOTCH4 (Notch Receptor 4): NOTCH4 is part of the Notch receptor family, which are key players in cell-to-cell communication, regulating cell fate decisions during development. NOTCH4 is particularly involved in vascular development and immune function. Abnormal NOTCH4 signaling can lead to developmental disorders and has been linked to diseases and certain types of cancer....



NOTCH4

TTN (Titin): TTN is one of the largest known proteins in the human body, primarily found in muscle tissues. It plays a crucial role in muscle contraction and elasticity. TTN acts as a molecular spring, providing structural support to muscle fibers and allowing them to contract and relax efficiently. Mutations in the TTN gene have been associated with various muscle-related disorders, including muscular dystrophy and cardiomyopathy....

Citrulline boosts blood flow and muscle endurance. It makes nitric oxide, which widens blood vessels. This nutrient, found in watermelons, cucumbers, and pumpkins, is popular among athletes. It enhances exercise performance, reduces fatigue, and speeds up recovery. Citrulline is key for healthy circulation and effective exercise....

Citrulline

NOTCH1 (Notch Receptor 1): NOTCH1 is a critical component of the Notch signaling pathway, which influences cell fate determination, stem cell maintenance, and differentiation during embryonic and adult tissue development. Dysregulation of NOTCH1 signaling contributes to a variety of disorders, notably including several forms of cancer, such as T-cell acute lymphoblastic leukemia, and developmental abnormalities. The pathway's broad impact on cell proliferation and differentiation makes it a significant focus in developmental biology and oncology research....



NOTCH1

ADARB2 (Adenosine Deaminase RNA-Specific B2): ADARB2 is an enzyme that belongs to the adenosine deaminase family and is involved in RNA editing. It specifically deaminates adenosine to inosine in RNA molecules, leading to alterations in RNA sequences. This post-transcriptional modification can impact the structure and function of RNA, potentially influencing various cellular processes and gene expression regulation....




ADARB2

TXLNA (Taxilin Alpha): TXLNA is involved in vesicle trafficking, protein transport, and possibly in the regulation of exocytosis. It interacts with various proteins, playing a role in the organization of intracellular transport systems. TXLNA's function in cellular logistics is important for maintaining cell homeostasis and may have implications for neurodegenerative diseases and disorders affecting protein transport and secretion....

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