Secondary bile acids
Secondary bile acids are produced in the colon through the bacterial conversion of primary bile acids, which are originally synthesised in the liver. While they contribute to digestion and regulation of the microbiota, elevated levels may indicate dysbiosis, excessive fat consumption, or altered bile acid metabolism. Certain secondary bile acids, such as deoxycholic acid (DCA) and lithocholic acid (LCA), have been linked to mucosal irritation, inflammation, and a higher risk of colorectal disorders when persistently raised. Measuring them in stool samples aids in evaluating gut microbial activity and the status of bile detoxification.
Description
They are bile acids produced by intestinal bacteria from primary bile acids that originate in the liver.
To assess microbial activity, fat digestion, and potential mucosal effects associated with bile acid transformation.
It can indicate dysbiosis, a high fat intake, or slowed intestinal transit, and may contribute to gut inflammation.
Not necessarily. In small amounts they assist digestion, but chronically elevated levels may be irritating or pro-inflammatory.
Diet (particularly fat and fibre), microbial composition, and bile acid recycling efficiency all play a role.
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