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The GetTested DNA Metabolic Health Test provides you with an in-depth understanding of your metabolic health by analyzing 240 carefully selected genes. This comprehensive analysis offers insights into your metabolism, blood sugar, weight, thyroid, parathyroid, and much more, along with personalized recommendations based on your genetics.

<p>The GetTested DNA Metabolic Health Test provides you with an in-depth understanding of your metabolic health by analyzing 240 carefully selected genes. This comprehensive analysis offers insights into your metabolism, blood sugar, weight, thyroid, parathyroid, and much more, along with personalized recommendations based on your genetics.</p>

DNA Metabolic Health Test

Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.

<p>Do you often find yourself feeling tired and drained, even after a full night’s sleep? Fatigue can take a toll on your daily life and overall well-being. But what if you could uncover the genetic factors contributing to your low energy levels? GetTested’s DNA Fatigue is a comprehensive analysis of 240 carefully selected genes that can shed light on the underlying causes of your fatigue.</p>

DNA Fatigue Test

SOCS2 (Suppressor of Cytokine Signaling 2): SOCS2 is a key regulator in the cytokine signaling pathway, part of a family of proteins that negatively regulate cytokine signaling to maintain immune balance and prevent excessive inflammation. It targets signaling pathways initiated by growth hormones and various cytokines to control cell growth, differentiation, and apoptosis. SOCS2's role in modulating immune responses and its involvement in metabolic regulation make it a subject of interest for understanding immune disorders, cancers, and metabolic diseases. Research into SOCS2 aims to uncover its potential as a therapeutic target for managing diseases related to immune dysregulation and metabolic...



SOCS2

SOD3 (Superoxide Dismutase 3): SOD3 emerges as a defender against oxidative stress, with a specific role in dismutating superoxide radicals. This enzyme operates as a guardian of tissues and cells, protecting them from the damaging effects of reactive oxygen species. SOD3's contributions extend to cardiovascular health and tissue protection, positioning it as a key player in our body's defense mechanisms....



SOD3

GDPD5 (Glycerophosphodiester Phosphodiesterase Domain Containing 5): GDPD5 is involved in lipid metabolism, specifically in the hydrolysis of glycerophosphodiesters to glycerol phosphate and alcohol. This enzymatic activity is important for the degradation of cellular membrane components and the regulation of intracellular signaling molecules. Understanding the function of GDPD5 contributes to our knowledge of lipid signaling pathways and their implications in metabolic and cardiovascular diseases....

GDPD5

GFI1 (Growth Factor Independent 1 Transcriptional Repressor): GFI1 functions as a transcriptional repressor, playing a pivotal role in hematopoiesis, the immune response, and the regulation of stem cell differentiation. It is essential for the development and function of neutrophils and T cells. Mutations or dysregulation of GFI1 are linked to immune deficiencies and leukemias, reflecting its critical role in maintaining immune system balance and hematologic health....

GFI1

SORBS3 (Sorbin And SH3 Domain Containing 3): SORBS3, also known as vinexin, is involved in cytoskeletal organization and cell signaling. It plays a role in linking the cytoskeleton to the cell membrane and is involved in signal transduction pathways related to cell movement and adhesion. Alterations in SORBS3 function can affect cellular architecture and have implications in cancer progression and metastasis....



SORBS3

GFI1B (Growth Factor Independence 1B): GFI1B is a transcriptional repressor essential for the development and differentiation of red blood cells and platelets. It regulates genes critical for cell cycle and apoptosis, ensuring a balance between cell growth and maturation. Dysregulation of GFI1B is linked to blood disorders like anemia and thrombocytopenia, and it plays a role in leukemia development. Its function is pivotal in maintaining hematopoietic cell balance and underscores the complexity of blood cell production....

GFI1B

GLRB (Glycine Receptor Beta Subunit): GLRB is part of the glycine receptor complex, a chloride channel involved in inhibitory neurotransmission in the spinal cord and brainstem. Glycine receptors are critical for motor and sensory functions, and mutations in GLRB can lead to neurological disorders, such as hyperekplexia, which is characterized by an exaggerated startle response. Understanding GLRB's role in neurotransmission provides insights into the mechanisms underlying inhibitory pathways and associated disorders....

GLRB

GIGYF1 (GRB10 Interacting GYF Protein 1): GIGYF1 is a critical adaptor protein involved in mediating cellular signaling pathways, particularly those associated with insulin receptor and IGF-1 receptor signaling. It interacts with the GRB10 protein, playing a pivotal role in the regulation of cell growth, differentiation, and metabolism. Through its involvement in these pathways, GIGYF1 contributes to the fine-tuning of insulin sensitivity and glucose homeostasis, implicating it in metabolic regulation and the pathophysiology of diabetes. Moreover, GIGYF1 has been linked to the regulation of mRNA translation and stability, underscoring its role in controlling gene expression at the post-transcriptional level. Dysregulation of...

GIGYF1

GLRX3 (Glutaredoxin 3): GLRX3, a member of the glutaredoxin family, plays a pivotal role in maintaining cellular redox balance by catalyzing the reversible oxidation and reduction of protein disulfide bonds. This activity is crucial in protecting cells from oxidative stress, which can lead to cellular damage and is implicated in various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders. GLRX3's antioxidant function also has implications in the regulation of cellular signaling pathways, particularly those affected by redox changes, highlighting its importance in cellular health and the stress response....

GLRX3

Gluten Sensitivity (Non-Celiac): Non-celiac gluten sensitivity (NCGS) is a condition where individuals experience symptoms similar to celiac disease upon consuming gluten, but without the autoimmune intestinal damage seen in celiac disease. The exact cause is unknown, but it's believed to involve an innate immune response to gluten in genetically predisposed individuals....

Gluten Sensitivity

GIPR (Glucose-Dependent Insulinotropic Polypeptide Receptor): GIPR encodes the receptor for glucose-dependent insulinotropic polypeptide (GIP), a hormone that stimulates insulin secretion in response to food intake. GIPR plays a role in glucose metabolism and insulin regulation....

GIPR

GLYCTK (Glycerate Kinase): GLYCTK is an enzyme involved in the metabolism of glycerate, a compound in glycolysis and gluconeogenesis pathways. Dysfunctions in GLYCTK can affect energy metabolism and have been linked to D-glyceric aciduria, a rare metabolic disorder....

GLYCTK

GNAQ (G Protein Subunit Alpha Q): GNAQ is a subunit of G proteins, which play a crucial role in transmitting signals from the cell surface to its interior. Mutations in GNAQ have been implicated in several types of tumors, including uveal melanoma, and in Sturge-Weber syndrome, a neurological and skin disorder....

GNAQ

GNB3: GNB3 encodes a subunit of G proteins, which are vital for transmitting various extracellular signals into the cell. The GNB3 gene is particularly known for a polymorphism (C825T) associated with various physiological responses, including hypertension and obesity. This makes it a gene of interest in understanding individual differences in response to medications and susceptibility to certain diseases....

GNB3

GNB5 (G Protein Subunit Beta 5): GNB5 is a component of heterotrimeric G proteins, which mediate various cellular responses to external stimuli through signal transduction pathways. It is involved in regulating heart rate, vision, and neurotransmission, highlighting its importance in both the central and peripheral nervous systems. Mutations in GNB5 are associated with arrhythmias and neurodevelopmental disorders, making it a key subject for studies on signal transduction and its related pathologies....

GNB5

GNG11 (G Protein Subunit Gamma 11): GNG11 is a component of heterotrimeric G proteins, which play a pivotal role in intracellular signaling pathways initiated by G protein-coupled receptors (GPCRs). Specifically, GNG11 is a gamma subunit, involved in the modulation of signal transduction across cell membranes, affecting a wide range of physiological processes including sensory perception, immune responses, and cell growth. Its role is critical in the transmission of signals from the extracellular environment to the cell's interior, leading to cellular responses. The precise function of GNG11 involves its interaction with the beta subunit of the G protein to form a...

GNG11

GNGT2, also known as Guanine nucleotide-binding protein G(t) subunit gamma-T2, is a protein that belongs to the family of guanine nucleotide-binding proteins (G proteins). GNGT2 is a subunit of the transducin complex, which plays a critical role in signal transduction in photoreceptor cells of the retina. One of the primary functions of GNGT2 is its involvement in the phototransduction cascade, a process by which light stimuli are converted into electrical signals that can be interpreted by the brain. In the retina, photoreceptor cells contain light-sensitive proteins called opsins, which undergo a conformational change upon absorbing photons. This change activates the associated...

GNGT2

GNL3 (Guanine Nucleotide Binding Protein-Like 3): GNL3, also known as nucleostemin, is involved in cell proliferation and stem cell maintenance. It is notable for its role in the regulation of the cell cycle in stem cells and cancer cells. GNL3 has been studied in the context of its potential roles in tumorigenesis and cellular aging....

GNL3

GNMT (Glycine N-Methyltransferase) plays a crucial role in methionine metabolism and liver detoxification. It regulates homocysteine levels by converting excess methionine into sarcosine, thereby preventing methionine buildup and maintaining liver health. GNMT's dysfunction is linked to liver disorders, including fatty liver disease and liver cancer. Research on GNMT offers insights into its protective role against liver toxicity and its potential as a marker for liver health assessment....

GNMT

GNPDA2 (Glucosamine-6-Phosphate Deaminase 2): GNPDA2 is involved in glucose metabolism and is associated with glycemic control. It plays a role in the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a step in glucose utilization. Variations in GNPDA2 have been linked to type 2 diabetes risk and glucose homeostasis....

GNPDA2

TYK2 (Tyrosine Kinase 2): TYK2 encodes a tyrosine kinase enzyme that plays a role in signaling pathways mediated by various cytokines, including interferons and interleukins. TYK2 is involved in immune responses and inflammation regulation....




TYK2

TYR (Tyrosinase): TYR is an enzyme crucial in the melanin biosynthesis pathway, responsible for the initial steps of converting tyrosine into melanin pigments. Melanin is essential for coloration in the skin, hair, and eyes, and plays a protective role against UV radiation. Mutations in TYR are associated with albinism, a condition characterized by a deficiency or absence of melanin, leading to visual problems and increased skin cancer risk. TYR's function in pigmentation underscores its importance in protecting against UV-induced damage and in normal visual system development. ...




UBE2G1 (Ubiquitin-conjugating Enzyme E2 G1): UBE2G1 is a member of the ubiquitin-conjugating enzyme family, playing a pivotal role in the ubiquitin-proteasome system, a fundamental cellular pathway responsible for protein degradation and turnover. Specifically, UBE2G1 functions in the conjugation of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. This enzymatic process is crucial for regulating various cellular functions, including cell cycle progression, DNA repair, and signal transduction. UBE2G1's activity is tightly regulated and orchestrated in concert with other components of the ubiquitin-proteasome system to ensure proper protein homeostasis and cellular function. Dysregulation of UBE2G1 has been implicated...




UBE2G1

UBE4B (Ubiquitination Factor E4B): UBE4B is involved in the ubiquitin-proteasome system, facilitating the degradation of damaged or misfolded proteins. It plays a role in maintaining protein quality control within cells, with implications for neuronal health and function. Dysregulation of UBE4B has been linked to neurodegenerative diseases, highlighting its importance in cellular stress responses and the potential for targeting in disease therapies....




UBE4B

UBL3 (Ubiquitin-Like 3): UBL3 encodes a protein that is similar to ubiquitin, a key player in the protein degradation pathway. It is involved in protein modification and has been implicated in cellular processes like signal transduction and membrane trafficking. Dysregulation of UBL3 may have implications in various cellular dysfunctions....

UBL3

GJA10 (Gap Junction Protein Alpha 10): GJA10 encodes a connexin protein that forms gap junction channels, allowing for the direct transfer of ions and small molecules between cells. This intercellular communication is crucial for maintaining tissue homeostasis and supporting coordinated cellular functions. GJA10 is particularly important in the eye, where it contributes to the transparency and function of the lens. Mutations in GJA10 have been linked to cataract formation and other ocular disorders....

GJA10

GLIS1 (GLIS Family Zinc Finger 1): GLIS1 encodes a transcription factor involved in the regulation of gene expression in the development and function of various tissues, including the reproductive system and skin. It has been implicated in reprogramming somatic cells to pluripotent stem cells, suggesting its potential in regenerative medicine....

GLIS1

GLIS3 (GLIS Family Zinc Finger 3): GLIS3 is a transcription factor that plays a significant role in the regulation of gene expression in various biological processes, including thyroid hormone signaling and pancreatic beta-cell development. Mutations in GLIS3 have been linked to a range of disorders, including congenital hypothyroidism and neonatal diabetes, underscoring its importance in endocrine function and development....

GLIS3

GLO1 (Glyoxalase I): GLO1 encodes an enzyme called glyoxalase I, which is involved in the detoxification of methylglyoxal, a cytotoxic byproduct of metabolism. GLO1 plays a role in cellular protection against oxidative stress and has implications in diabetes and other diseases where glyoxalase activity is relevant....

GLO1

GLP1R (Glucagon-Like Peptide 1 Receptor): GLP1R encodes the receptor for glucagon-like peptide 1 (GLP-1), a hormone that regulates insulin secretion and glucose metabolism. Activation of GLP1R by GLP-1 or GLP-1 analogs enhances insulin release, suppresses glucagon secretion, and promotes satiety, making it a key target for medications used to treat type 2 diabetes and obesity....

GLP1R

UBLCP1 (Ubiquitin Like Domain Containing CTD Phosphatase 1): UBLCP1 encodes a protein phosphatase that is involved in the regulation of RNA polymerase II, a key enzyme in the transcription process. Its role in the dephosphorylation of the C-terminal domain of RNA polymerase II highlights its significance in the regulation of gene expression, with implications in various cellular processes and diseases....

UBLCP1

UBQLN2, also known as Ubiquilin-2, is a protein involved in the ubiquitin-proteasome system (UPS), a crucial pathway for protein degradation within cells. It belongs to the ubiquilin family of proteins, which are characterized by containing ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains that facilitate interactions with ubiquitinated proteins and proteasome components. One of the primary functions of UBQLN2 is its role in protein quality control and degradation. UBQLN2 acts as a shuttle factor, facilitating the delivery of ubiquitinated proteins to the proteasome for degradation. It binds to ubiquitinated proteins through its UBA domain and interacts with components of the proteasome, promoting the...




UBQLN2

UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5): UBR5 is a gene that encodes an E3 ubiquitin ligase, which is involved in protein degradation via the ubiquitin-proteasome pathway. UBR5 plays a role in the regulation of protein stability and turnover. Dysfunctions in UBR5 can impact various cellular processes and have implications in cancer development and neurodegenerative diseases. Understanding UBR5 is significant for research into protein homeostasis and cellular quality control....




UBR5

GOLGA8B (Golgin A8 Family Member B): GOLGA8B is a member of the golgin family of proteins, involved in the structure and function of the Golgi apparatus. It plays a role in vesicle trafficking and cellular organization, although its specific functions are not fully understood....

GOLGA8B

UBXN2A (UBX Domain Protein 2A): UBXN2A is involved in the ubiquitin-proteasome system, which regulates protein degradation and quality control in cells. It may play a role in the response to cellular stress and in the regulation of protein turnover, which is vital for maintaining cellular health and preventing diseases....




UBXN2A

GP2 (Glycoprotein 2): GP2 is a membrane-bound protein primarily found in the pancreas and is involved in immune responses in the gastrointestinal tract. It is important for the binding and aggregation of bacteria, playing a role in protecting the gut from microbial invasion. Alterations in GP2 are studied in the context of pancreatic disorders and inflammatory bowel diseases....

ZNF816 (Zinc Finger Protein 816): ZNF816 belongs to the family of zinc finger proteins, which are involved in DNA binding and gene transcription regulation. Although specific functions of ZNF816 are less characterized, zinc finger proteins play crucial roles in developmental processes, cellular differentiation, and the regulation of gene expression. Research on ZNF816 and similar proteins aims to uncover their contributions to cellular processes and their potential links to diseases, including cancer and genetic disorders....

ZNF816

GPD2 (Glycerol-3-Phosphate Dehydrogenase 2): GPD2 is an enzyme involved in glycerol metabolism and lipid biosynthesis. It catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, a critical step in lipid synthesis. GPD2's function is important for energy storage and lipid homeostasis....

GPD2

UCN3, also known as Urocortin 3, is a peptide hormone belonging to the corticotropin-releasing factor (CRF) family. It is primarily expressed in the central nervous system, particularly in regions of the brain involved in stress response regulation, such as the hypothalamus, amygdala, and brainstem. One of the primary functions of UCN3 is its role in modulating the stress response and anxiety-related behaviors. Like other members of the CRF family, UCN3 acts as a neuromodulator, influencing the activity of neurons and circuits involved in the physiological and behavioral responses to stress. UCN3 binds to and activates specific receptors, including CRF receptor type...




UCN3

ZSCAN31 (Zinc Finger And SCAN Domain Containing 31): ZSCAN31 is a member of the zinc finger protein family, which is involved in DNA binding and gene transcription regulation. While specific functions of ZSCAN31 are still being elucidated, zinc finger proteins play significant roles in developmental processes, cellular differentiation, and the regulation of gene expression. Research on ZSCAN31 focuses on understanding its contribution to genetic regulation and its potential link to diseases, including its role in chromosomal stability and cancer....




ZSCAN31

GPM6A (Glycoprotein M6A): GPM6A encodes a glycoprotein primarily expressed in the nervous system, playing a critical role in neurite outgrowth and the formation of neuronal networks. It's involved in the development and maintenance of the myelin sheath, crucial for efficient nerve signal transmission. GPM6A has been implicated in neurological disorders, including schizophrenia and bipolar disorder, due to its role in neuronal plasticity and myelination. Research suggests that alterations in GPM6A expression or function can impact synaptic connectivity and brain function, potentially contributing to the pathophysiology of these neuropsychiatric conditions....

GPM6A

BLMH (Bleomycin Hydrolase): BLMH is an enzyme crucial for metabolizing and detoxifying the chemotherapeutic drug bleomycin. Bleomycin is effective in treating cancer by causing DNA damage in cancer cells, but it can also lead to lung toxicity as a side effect. BLMH plays a pivotal role in breaking down bleomycin into harmless compounds, reducing the risk of lung toxicity. Understanding BLMH's function is vital for optimizing cancer treatment and managing its side effects, particularly in patients receiving bleomycin-based therapies. Researchers are actively exploring strategies to enhance the safety and effectiveness of cancer treatments involving bleomycin....



BLMH

GPR139, also known as G protein-coupled receptor 139, is a protein that belongs to the G protein-coupled receptor (GPCR) superfamily. It is primarily expressed in the central nervous system, particularly in regions associated with the regulation of neurotransmitter systems and neuronal activity. Although the specific functions of GPR139 are still being elucidated, it is believed to play a role in modulating neurotransmission, particularly in the regulation of dopamine and glutamate signaling. Studies have suggested that GPR139 may function as an inhibitory receptor, as its activation leads to decreased cAMP (cyclic adenosine monophosphate) levels and reduced neuronal excitability. Moreover, GPR139 has been implicated...

GPR139

BLOC1S2 (Biogenesis of Lysosomal Organelles Complex-1, Subunit 2): BLOC1S2 is part of a protein complex involved in the biogenesis of lysosome-related organelles, such as melanosomes and platelet dense granules. Dysfunctions in BLOC1S2 can affect organelle formation and function, potentially leading to disorders related to pigmentation or blood clotting....



BLOC1S2

UCP3 (Uncoupling Protein 3): UCP3 is a member of the mitochondrial uncoupling proteins, playing a role in thermogenesis and energy balance. It is implicated in the regulation of body weight and metabolism, and its activity can influence obesity and metabolic disorders....




UCP3

BMP2 (Bone Morphogenetic Protein 2): BMP2 is a member of the TGF-beta superfamily, known for its critical roles in bone and cartilage development. It induces bone formation and regeneration, making it a key factor in skeletal homeostasis. Dysregulation of BMP2 signaling has been associated with various skeletal disorders and has implications in cardiovascular disease, underscoring its potential in regenerative medicine and tissue engineering....



BMP2

UGT1A6 (UDP Glucuronosyltransferase Family 1 Member A6): UGT1A6 is a gene that encodes an enzyme from the UDP glucuronosyltransferase family. These enzymes play a vital role in phase II metabolism, where they facilitate the conjugation of drugs, toxins, and endogenous substances with glucuronic acid, aiding in their elimination from the body. UGT1A6's function is essential for detoxification processes and maintaining overall metabolic balance....

UGT1A6

GPR151 (G Protein-Coupled Receptor 151): GPR151 is a gene that encodes a G protein-coupled receptor (GPCR). GPCRs are involved in cell signaling and can respond to various signaling molecules. The specific function of GPR151 is still being investigated, but it may play a role in neural and metabolic processes....

GPR151

ULK3 (Unc-51 Like Kinase 3): ULK3 is part of the serine/threonine kinase family, involved in various cellular processes including autophagy, a mechanism for degrading and recycling cellular components. Its specific roles and implications in human health and disease are still being explored....




ULK3

BMP6 (Bone Morphogenetic Protein 6): BMP6 is part of the bone morphogenetic protein family, which is crucial in the development and repair of bone and cartilage. It is involved in various cellular processes including cell growth, apoptosis, and differentiation. BMP6 has been studied in the context of osteogenesis and is also implicated in cancer progression....



BMP6

UNC119B (UNC-119 Homolog B): UNC119B is involved in the trafficking of proteins to cilia, cellular structures important in signaling pathways and sensory functions. It plays a role in the development and function of photoreceptor cells in the retina. Dysfunctions in UNC119B can impact ciliary function, potentially leading to retinal diseases and impairing vision....

UNC119B

UNCX (Unc-4 Homeobox): UNCX encodes a homeobox-containing transcription factor involved in neuronal development and axon guidance. It plays a role in specifying neuronal identity and connectivity in the developing nervous system....




UNCX

UPB1 (Beta-Ureidopropionase 1): UPB1 is an enzyme involved in the catabolism of pyrimidines. Deficiencies in UPB1 can lead to beta-ureidopropionase deficiency, a rare disorder affecting the breakdown of nucleotides, leading to neurological symptoms and developmental delay....

UPB1

UPP1 (Uridine Phosphorylase 1): UPP1 is involved in the pyrimidine salvage pathway, converting uridine to uracil and ribose-1-phosphate. It plays a key role in nucleotide metabolism, impacting various cellular processes including DNA and RNA synthesis. Its function is particularly relevant in chemotherapy, as it affects the activation and effectiveness of certain anticancer drugs....

UPP1

GPR158 (G Protein-Coupled Receptor 158): GPR158 is a member of the G protein-coupled receptor family and is involved in various physiological processes, including neuronal development and regulation of mood and behavior. It has been implicated in conditions such as depression and anxiety, highlighting its role in mental health....

GPR158

BNIP5 (BCL2/Adenovirus E1B 19 kDa Interacting Protein 5): BNIP5 is involved in apoptosis and cell survival pathways. It interacts with members of the Bcl-2 family, proteins known for their roles in regulating cell death and survival, making it significant in studies of cancer and cellular stress responses....



BNIP5

GPR25 (G Protein-Coupled Receptor 25): GPR25 is part of the G protein-coupled receptor family and is implicated in various physiological processes, including signal transduction and cell communication. Its specific functions and roles in human health and disease are still under investigation....

GPR25

BORCS7 (BLOC-1 Related Complex Subunit 7): BORCS7 is a component of the BLOC-1 (Biogenesis of Lysosome-related Organelles Complex-1). It's involved in the biogenesis of lysosome-related organelles, such as melanosomes in melanocytes. Dysfunctions in BORCS7 may impact pigmentation and neurological functions....



BORCS7

GPR26 (G Protein-Coupled Receptor 26): GPR26 is an orphan receptor whose specific ligand and physiological role are not well-characterized. However, it is thought to be involved in central nervous system function, potentially playing a role in regulating mood and behavior. Studies suggest that GPR26 may have implications for neurological conditions and psychiatric disorders, making it a target of interest for drug discovery and neuroscience research....

GPR26

GPR83 (G Protein-Coupled Receptor 83): GPR83 is a G protein-coupled receptor (GPCR) that is expressed in the brain and is involved in the regulation of appetite and energy homeostasis. It has been studied in the context of feeding behavior and metabolic disorders....

GPR83

URAD (Ureidoimidazole-4-Carboxamide Ribonucleotide Decarboxylase): URAD is involved in the de novo synthesis of purine nucleotides, which are essential for DNA and RNA production. It plays a role in nucleotide metabolism and is critical for cell proliferation and growth....

URAD

BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase): BRAF is a key player in the MAPK/ERK signaling pathway, which regulates cell growth, proliferation, and differentiation. Mutations in BRAF are implicated in various cancers, including melanoma, thyroid cancer, and colorectal cancer. BRAF mutations are also involved in certain non-cancerous conditions, such as cardiofaciocutaneous syndrome, which affects the heart, facial features, and skin....



BRAF

USP25 (Ubiquitin Specific Peptidase 25): USP25 encodes an enzyme that is part of the ubiquitin-proteasome pathway, responsible for removing ubiquitin from proteins, thereby regulating their degradation. It is involved in various cellular processes, including signal transduction and stress response. Alterations in USP25 are linked to immune system dysregulation and potentially to cancer....




USP25

USP47 (Ubiquitin Specific Peptidase 47): USP47 is an enzyme that specifically removes ubiquitin from ubiquitinated proteins, thereby regulating their degradation. It plays a crucial role in DNA repair, cell cycle regulation, and signal transduction by maintaining protein stability. Dysregulation of USP47 has been implicated in the development of various cancers and other diseases, where it affects processes such as cell proliferation and apoptosis. Understanding USP47's function is essential for exploring new therapeutic strategies for cancer and other diseases associated with protein degradation pathways....

USP47

UST (Uronyl 2-Sulfotransferase): UST is an enzyme involved in the sulfation of proteoglycans, which are important components of the extracellular matrix. It plays a role in various biological processes, including cell signaling and tissue repair. Dysregulation of UST activity can impact connective tissue function and may be relevant in disorders involving the extracellular matrix....

GPSM1 (G Protein Signaling Modulator 1): GPSM1 is involved in modulating G protein signaling, crucial for various cellular responses to external stimuli. It plays a role in cell polarization and directional movement, and has been studied in the context of cancer, particularly in relation to its potential role in tumor cell migration and invasion....

GPSM1

UTP20 (UTP20, Small Subunit Processome Component): UTP20 is involved in the processing and assembly of the 18S rRNA, a crucial component of the small ribosomal subunit. It plays a role in ribosome biogenesis, which is essential for protein synthesis. Dysfunctions in UTP20 can affect cell growth and proliferation, with potential implications in developmental disorders and cancers....




UTP20

BRINP1, or BMP/retinoic acid-inducible neural-specific protein 1, is a member of the BRINP (BMP/retinoic acid-inducible neural-specific) family of proteins. It is predominantly expressed in the brain and has been implicated in various neuronal processes, including neurodevelopment, synaptic plasticity, and neuronal survival. One of the primary functions of BRINP1 is its involvement in neural development. It is induced by factors such as bone morphogenetic proteins (BMPs) and retinoic acid during early neural development, suggesting a role in patterning and differentiation of neural progenitor cells. BRINP1 expression is spatially and temporally regulated in the developing brain, suggesting its involvement in processes such as...



BRINP1

VAV2 (Vav Guanine Nucleotide Exchange Factor 2): VAV2 is a guanine nucleotide exchange factor (GEF) that is primarily involved in transducing signals from tyrosine kinase receptors to Rho GTPases, affecting cell morphology, motility, and proliferation. It plays a significant role in various cellular processes, including cytoskeletal dynamics and cell signaling pathways. Dysregulation of VAV2 has been linked to cancer progression, making it a subject of interest for understanding tumorigenesis and metastasis....




VAV2

VAV3 (Vav Guanine Nucleotide Exchange Factor 3): VAV3 encodes a guanine nucleotide exchange factor that is involved in intracellular signaling pathways related to cell proliferation and cytoskeletal rearrangement. It plays a role in immune cell activation and may have implications in immune responses and cancer....




VAV3

BRK1 (Breakpoint cluster region kinase 1): Similar to MMP15's pivotal role in extracellular matrix (ECM) remodeling, BRK1 is a crucial player in cellular signaling pathways that regulate cell proliferation, differentiation, and migration. As a member of the breakpoint cluster region kinase family, BRK1 modulates intracellular signaling cascades, influencing various physiological processes such as cell cycle progression, cytoskeletal organization, and cell adhesion. Additionally, BRK1 has been implicated in the regulation of immune responses and oncogenic signaling pathways, highlighting its significance in both normal physiological functions and disease pathogenesis. Dysregulation of BRK1 expression or activity has been associated with cancer progression, inflammatory...



BRK1

VCAN (Versican): VCAN is a gene that codes for versican, a large proteoglycan found in the extracellular matrix of tissues. Versican is involved in cell adhesion, migration, and tissue development. It plays a role in maintaining tissue structure and may contribute to processes like wound healing and embryonic development....

VCAN

GRAMD2B (GRAM Domain Containing 2B): GRAMD2B is part of the GRAM domain family, involved in cellular processes like lipid binding and transport. Its specific functions in human physiology are not fully understood, but such domains are often associated with membrane-related processes....

GRAMD2B

VEGFA (Vascular Endothelial Growth Factor A): Much like MMP15's involvement in tissue remodeling and angiogenesis, VEGFA holds a central role in regulating blood vessel formation and vascular function. As a key member of the vascular endothelial growth factor (VEGF) family, VEGFA stimulates the proliferation and migration of endothelial cells, promoting the formation of new blood vessels (angiogenesis) crucial for various physiological processes including wound healing, embryonic development, and tissue repair. The precise regulation of VEGFA expression and activity is essential for maintaining vascular integrity and homeostasis. Dysregulation of VEGFA signaling has been implicated in numerous pathological conditions, including cancer progression,...

VEGFA

BRSK2 (BR Serine/Threonine Kinase 2): BRSK2 is a member of the AMP-activated protein kinase family and is involved in neuronal development and polarization. It plays a role in synaptic plasticity and neuron maturation. Mutations or alterations in BRSK2 have implications in neurological disorders and could contribute to the development of neurodevelopmental diseases....



BRSK2

VIPR1 (Vasoactive Intestinal Peptide Receptor 1): VIPR1 encodes a receptor for vasoactive intestinal peptide, a neuropeptide involved in a wide range of physiological processes, including smooth muscle relaxation, immune regulation, and water and ion flux in the lungs. It plays a significant role in circadian rhythms and is implicated in various disorders, including asthma and pulmonary hypertension....

VIPR1

VIPR2 (Vasoactive Intestinal Peptide Receptor 2): VIPR2 encodes a receptor for vasoactive intestinal peptide (VIP), a neuropeptide involved in various physiological processes, including smooth muscle relaxation, immune modulation, and neurotransmission. VIPR2 is found on the surface of cells in various tissues and plays a role in VIP signaling....

VIPR2

BSN (Bassoon Presynaptic Cytomatrix Protein): BSN is crucial for the proper assembly of active zones at synaptic terminals, facilitating neurotransmitter release. This protein's role in the structural organization of synapses is vital for synaptic transmission and plasticity, impacting learning and memory. Alterations in BSN function or expression can influence neurological function and have been associated with various neuropsychiatric disorders....



VLDLR (Very Low Density Lipoprotein Receptor): VLDLR is a component of the lipid metabolism pathway, facilitating the uptake of triglyceride-rich lipoproteins into cells for energy utilization or storage. It plays a critical role in neuronal migration and cerebellar development. Mutations in VLDLR are associated with a rare genetic disorder known as dysequilibrium syndrome, characterized by cerebellar hypoplasia and cognitive disability, emphasizing its role in lipid metabolism and brain development....

VLDLR

GRIA1: GRIA1, or Glutamate Ionotropic Receptor AMPA Type Subunit 1, is a gene that encodes a key subunit of AMPA receptors, which are crucial for fast synaptic transmission in the brain. These receptors are responsive to the neurotransmitter glutamate, which is the most abundant excitatory neurotransmitter in the vertebrate nervous system. The GRIA1 subunit is integral in mediating synaptic plasticity, a foundation for learning and memory. Dysfunctions or mutations in GRIA1 have been implicated in various neurological disorders, including epilepsy and neurodegenerative diseases, making it a significant focus in neuroscience research....

GRIA1

VMP1 (Vacuole Membrane Protein 1): VMP1 is involved in autophagy, a critical cellular process for degrading and recycling cellular components. It's particularly important for the formation of autophagosomes, structures that encapsulate cellular material for degradation. Dysregulation of VMP1 can impact cellular homeostasis and is implicated in various diseases, including pancreatitis and some forms of cancer....

VMP1

VPS35L (VPS35 Retromer Complex Component Like): VPS35L is a component of the retromer complex, involved in the endosomal transport pathway crucial for recycling membrane proteins from endosomes to the Golgi apparatus or plasma membrane. While less studied than VPS35, VPS35L is believed to play a similar role in sorting and trafficking within cells, with implications for cellular homeostasis and signaling. Understanding its function is important for elucidating the mechanisms of protein recycling and its impact on various diseases, including neurodegenerative disorders....

VPS35L

GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2): GRIK2 is a critical subunit of the kainate receptors, which are glutamate-gated ion channels involved in excitatory neurotransmission in the central nervous system. These receptors play a pivotal role in synaptic transmission and plasticity, influencing learning, memory, and neural development. GRIK2's function is crucial for modulating neuronal excitability and has been implicated in various neurological conditions, including epilepsy, schizophrenia, and neurodegenerative diseases. Its involvement in the fine-tuning of synaptic activity makes GRIK2 a potential target for therapeutic interventions aimed at disorders characterized by aberrant glutamatergic signaling. Understanding the regulatory mechanisms of GRIK2...

GRIK2

VPS37B, a member of the vacuolar protein sorting (VPS) family, is a crucial component of the endosomal sorting complex required for transport (ESCRT) machinery. Located predominantly within the cytoplasm of cells, VPS37B plays a pivotal role in regulating intracellular membrane trafficking and protein sorting processes. One of the key functions of VPS37B is its involvement in the formation and function of multivesicular bodies (MVBs), specialized endosomal compartments responsible for sorting ubiquitinated membrane proteins destined for degradation in lysosomes. Within the ESCRT machinery, VPS37B interacts with other ESCRT components to facilitate the sequestration of cargo into intraluminal vesicles within MVBs, a process...

VPS37B

GRIN3A (Glutamate Ionotropic Receptor NMDA Type Subunit 3A): GRIN3A encodes a subunit of the NMDA receptor, a crucial component in synaptic plasticity and learning. As a part of the glutamate receptor family, NMDA receptors play a pivotal role in mediating neuronal communication. Their involvement in synaptic transmission and memory formation underscores their significance in neural function and neurological research....

GRIN3A

GRINA (Glia Derived Nexin): GRINA is a protein that is thought to play a critical role in the central nervous system, particularly in neuroprotection and the regulation of neuronal excitability. It is part of a larger complex involved in the modulation of NMDA (N-methyl-D-aspartate) receptors, which are essential for synaptic plasticity, memory formation, and learning. The function of GRINA is associated with its ability to influence the activity of these receptors, potentially affecting neurodevelopmental processes and neural response mechanisms. Dysregulation of GRINA has been linked to various neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia, suggesting its involvement in the...

GRINA

VWA2 (Von Willebrand Factor A Domain Containing 2): VWA2 is involved in extracellular matrix (ECM) organization and cell-matrix adhesion, playing a role in tissue development and repair. It contains a Von Willebrand factor type A domain, typically associated with mediating interactions between proteins. VWA2's function in ECM stability and cell adhesion is critical for proper tissue architecture and function, with potential relevance to wound healing and diseases characterized by ECM dysregulation....

VWA2

VWC2L (von Willebrand Factor C Domain Containing Protein 2 Like): VWC2L is a less-characterized protein with a von Willebrand factor C domain, typically involved in extracellular matrix interactions and cell adhesion processes. It might play a role in tissue development and integrity, but its specific functions in human physiology and pathology remain to be fully explored....




VWC2L

GRM1 (Glutamate Receptor, Metabotropic 1): GRM1 is a receptor for glutamate, the primary excitatory neurotransmitter in the nervous system. It plays a crucial role in modulating synaptic plasticity, learning, and memory. GRM1 is involved in various neural pathways and has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, and neurodegenerative diseases. Its role in neurotransmission and brain function makes it a potential target for therapeutic interventions in these conditions....

GRM1

WDFY2 (WD Repeat and FYVE Domain Containing 2): WDFY2 is a protein involved in endosomal sorting and trafficking. It contains both WD repeats and an FYVE domain, suggesting a role in vesicle-mediated transport processes and potentially in signaling pathways involving membrane dynamics. The specific functions of WDFY2 in cellular processes and its implications in human health and disease are still under investigation....

WDFY2

WDR70 (WD Repeat Domain 70): WDR70 is a gene that encodes a protein with a WD repeat domain, known for facilitating protein-protein interactions. This gene is implicated in various cellular processes, including cell cycle regulation and possibly RNA processing. The specific functions of WDR70 are not fully understood, but it's believed to play a role in cellular organization and function....




WDR70

BTBD7 (BTB Domain Containing 7): BTBD7 plays a key role in regulating epithelial-mesenchymal transition (EMT), a critical process in embryonic development, wound healing, and tumor metastasis. It functions by modulating the cytoskeletal architecture, thereby influencing cell shape, migration, and invasion. Dysregulation of BTBD7 has been linked to fibrosis and cancer progression, underlining its importance in tissue remodeling and its potential as a target for therapeutic intervention in fibrotic diseases and metastatic cancers....



BTBD7

WNK1 (WNK Lysine Deficient Protein Kinase 1): WNK1 is a serine/threonine kinase involved in regulating electrolyte balance and blood pressure. It affects sodium and potassium transport in the kidneys, influencing fluid balance and blood pressure. Mutations in WNK1 can lead to hereditary hypertension and electrolyte imbalances, making it a key gene in understanding certain forms of high blood pressure....




WNK1

WNT10A (Wnt Family Member 10A): WNT10A is involved in the Wnt signaling pathway, crucial for regulating cell fate determination, patterning, and morphogenesis. It plays a significant role in the development of skin, hair, teeth, and bones, with mutations leading to a range of developmental disorders....




WNT10A

BTG1 (B-cell Translocation Gene 1): BTG1 is a gene with diverse cellular roles, primarily centered around cell cycle regulation and cellular differentiation. It operates as a tumor suppressor gene in certain contexts, exerting influence over cell growth and proliferation. Beyond its tumor-suppressive functions, BTG1 also participates in various cellular processes, making it a subject of interest in cancer research and developmental biology....



BTG1

WNT7B (Wnt Family Member 7B): WNT7B is part of the Wnt signaling pathway, playing a critical role in embryonic development, cell proliferation, and differentiation. This pathway is essential for the regulation of gene expression, cellular architecture, and tissue repair. Aberrant WNT7B signaling has been associated with various pathologies, including developmental disorders, fibrosis, and cancer, particularly in the regulation of tumor growth and metastasis, emphasizing its significance in cellular growth and disease progression....

SLC30A8

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