SLC45A2
SLC45A2 (Solute Carrier Family 45 Member 2): SLC45A2 is a protein involved in melanin production, functioning as a transporter of tyrosine, a crucial precursor in the melanin biosynthesis pathway. Variants of SLC45A2 contribute to human pigmentation differences, affecting skin, hair, and eye colour. Mutations in this gene can cause oculocutaneous albinism type 4, characterised by reduced pigmentation and visual impairments. The role of SLC45A2 in pigmentation influences not only physical appearance but also protection against UV radiation and the regulation of vitamin D synthesis.
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