SLCO1B1

SLCO1B1, also known as Solute Carrier Organic Anion Transporter Family Member 1B1, is a membrane-bound transporter protein primarily found in the liver. It plays a crucial role in the uptake of various endogenous and exogenous compounds, including bile acids, hormones, drugs, and toxins, from the bloodstream into hepatocytes (liver cells). One of the primary functions of SLCO1B1 is its involvement in the hepatic uptake of bile acids, a process essential for bile acid homeostasis and bile formation. By transporting bile acids across the sinusoidal membrane of hepatocytes, SLCO1B1 facilitates their clearance from the bloodstream and their subsequent incorporation into bile, which...