SOAT2 (Sterol O-Acyltransferase 2): SOAT2 is an enzyme that represents a crucial step in lipid metabolism, particularly in the esterification of cholesterol. It plays a vital role in regulating cellular cholesterol levels by converting free cholesterol into cholesterol esters, which are either stored in lipid droplets or transported via lipoproteins. SOAT2 is primarily expressed in tissues involved in lipid metabolism, including the liver, intestine, and macrophages. Its activity is tightly regulated and responsive to cholesterol levels, helping to prevent cholesterol toxicity and maintain lipid balance.