SPPL3

SPPL3 (Signal Peptide Peptidase Like 3): SPPL3 is part of the intramembrane-cleaving protease family, involved in the processing of various transmembrane proteins. It plays a role in cellular signaling and regulation by cleaving the intracellular domains of its substrates, thereby modulating their function. SPPL3 is important in immune system regulation, particularly in the maturation of B cells, and has been implicated in certain autoimmune conditions. Its study is significant for understanding the mechanisms of intramembrane proteolysis and its implications in human health and disease....