TENM3
TENM3 (Teneurin-3): TENM3 is a gene that encodes a transmembrane protein from the teneurin family, which serves as a multifunctional regulator in neural development and synaptic connectivity. This protein directs axonal pathfinding, dendritic growth, and synaptic organisation, playing a crucial role in the formation and refinement of neural circuits. Beyond development, TENM3 also supports synaptic maintenance and plasticity in the adult nervous system, influencing processes such as synaptic pruning and neurotransmitter release. Dysregulation of TENM3 has been associated with neurological disorders including autism spectrum disorders and schizophrenia, emphasising its vital role in brain function.
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