TGM2 (Transglutaminase 2): TGM2 is a multifunctional enzyme that catalyses the cross-linking of glutamine and lysine residues in proteins, a key post-translational modification. It participates in essential cellular processes such as apoptosis, cell differentiation, and tissue repair by stabilising and remodelling the extracellular matrix. TGM2 is implicated in various disease pathways, including neurodegenerative disorders, fibrotic diseases, and certain cancers, where altered activity can drive disease progression. It also plays a role in immune responses, notably in coeliac disease.