TIAM2

TIAM2, also known as T-lymphoma invasion and metastasis-inducing protein 2, is a critical member of the TIAM family of guanine nucleotide exchange factors (GEFs). Positioned primarily within the cytoplasm of cells, TIAM2 plays a pivotal role in regulating cellular processes, particularly those related to cytoskeletal dynamics, cell migration, and invasion. One of the distinctive features of TIAM2 is its ability to act as a molecular switch for the activation of Rho GTPases, particularly Rac1. Through its GEF activity, TIAM2 catalyzes the exchange of GDP for GTP on Rac1, leading to the activation of downstream signaling pathways involved in actin cytoskeleton rearrangements...