TNFAIP3
TNFAIP3 (TNF Alpha Induced Protein 3): Also known as A20, TNFAIP3 is a critical negative regulator of NF-kB signaling and plays a pivotal role in controlling inflammation and immune responses. It acts by ubiquitinating signaling molecules to terminate NF-kB activation, thus preventing prolonged inflammatory responses that can lead to autoimmune diseases. Mutations or dysregulation of TNFAIP3 are associated with several autoimmune and inflammatory diseases, making it a key target for therapeutic research....
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