TNFSF12

TNFSF12, also known as Tumor Necrosis Factor Ligand Superfamily Member 12 or TWEAK (TNF-like weak inducer of apoptosis), is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It plays diverse roles in inflammation, immunity, tissue homeostasis, and cell death regulation. One of the primary functions of TNFSF12 is its role in modulating immune responses and inflammation. TNFSF12 can act as both a pro-inflammatory and anti-inflammatory cytokine, depending on the cellular context and signaling pathways involved. It promotes the production of inflammatory cytokines and chemokines, recruits immune cells to sites of inflammation, and stimulates the activation of endothelial cells and...