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Transglutaminase IgG
Transglutaminase IgG (tTG-IgG) is a blood test that detects IgG antibodies against tissue transglutaminase, an enzyme found in the lining of the intestines. It is primarily used to assist in diagnosing coeliac disease, particularly in individuals with IgA deficiency or inconclusive tTG-IgA results, by indicating an immune response to gluten.
Description
What are the typical symptoms indicating a need for the Transglutaminase IgG test?
Symptoms that might indicate a need for testing include gastrointestinal issues like chronic diarrhea and abdominal pain, as well as extraintestinal symptoms such as anemia, dermatitis herpetiformis (a skin rash), and growth problems in children, all of which could suggest celiac disease.
How is the Transglutaminase IgG test performed?
The test requires a blood sample from the patient. This sample is analyzed in a laboratory to measure the levels of IgG antibodies against tissue transglutaminase. Elevated levels of these antibodies suggest an immune reaction to gluten.
What causes positive results in a Transglutaminase IgG test?
A positive result typically indicates an autoimmune response to gluten, as seen in celiac disease, where the body’s immune system mistakenly targets the small intestine. This reaction is triggered by the ingestion of gluten-containing foods.
Who should undergo the Transglutaminase IgG test?
The tTG-IgG test is recommended for individuals who show symptoms of celiac disease but have an IgA deficiency, making the tTG-IgA test less useful. Symptoms prompting this test include chronic diarrhea, abdominal pain, bloating, weight loss, and malnutrition.
Tests containing this item
Lab TestIf you’re experiencing symptoms like digestive discomfort, fatigue, or other issues potentially related to gluten sensitivity, GetTested’s Gluten Intolerance Test may provide the clarity you need. This test measures the concentration of IgG antibodies against tissue transglutaminase (tTG) in your blood, which can reveal a sensitivity that not only identifies confirmed coeliac cases but also those who are gluten-sensitive and may not show results on traditional tests.
49.99 GBP
