TSKU (Tafazzin Knockdown Factor Upstream): TSKU is a gene associated with tafazzin, an enzyme involved in the biosynthesis of cardiolipin, a phospholipid found in the inner mitochondrial membrane. Tafazzin plays a pivotal role in mitochondrial function and energy production. The role of TSKU in regulating tafazzin indicates its significance in preserving mitochondrial membrane integrity.